Pharmacotherapy efficacy and safety criteria based on spectral shifts in elder patients with arterial hypertension and coronary artery disease

The article is dedicated to development of homeostatic criteria of efficacy and safety of drugs combinations “lisinopril, bisoprolol, indapamide, isosorbide dinitrate, acetylsalicylic acid”. These criteria are based on study of homeostatic shifts and their association with clinical and laboratory parameters on elder patients with arterial hypertension (AH) II, III stage combined with coronary artery disease (CAD). Complex clinical, biochemical, biophysical and instrumental investigation was performed in 67 patients with AH II, III stage combined with CAD. On the grounds of developed criteria was established that for patients with AH II and CAD is not recommended combination “lisinopril, acetylsalicylic acid” and for those ones with AH III and CAD prohibited combinations “lisinopril, bisoprolol, acetylsalicylic acid” and “lisinopril, bisoprolol, indapamide, isosorbide dinitrate, acetylsalicylic acid” in order to prevent development of drug induced renal dysfunction. It was also determined safety of combinations “lisinopril, bisoprolol, acetylsalicylic acid”; “lisinopril, bisoprolol, indapamide, acetylsalicylic acid” for patients with AH II and CAD and “lisinopril, bisoprolol, indapamide, acetylsalicylic acid” for those ones with AH III and CAD

Importance of blood pressue variability for stratification and control of risk in patients suffering from arterial hypertension

Рассмотрены механизмы, определяющие формирование вариабельности артериального давления (АД), проведен сравнительный анализ методов её оценки. Показано, что разница систолического АД более чем 15 мм рт. ст. может использоваться как индикатор риска заболевания периферических сосудов и кардиоваскулярной смерти. Величина утреннего повышения АД при его суточном мониторировании является сильным предиктором инсульта, особенно у леченных пациентов. Приведены данные о корреляции повышенной вариабельности АД с увеличением риска смерти у гипертензивных больных. Показано, что эффективность терапии пациентов с артериальной гипертензией увеличивается, если антигипертензивные препараты и их комбинации снижают вариабельность АД.Effective control of blood pressure (BP) remains a key factor in the reduction of cardiovascular morbidity and mortality. It is shown that regardless of a BP measurement method, a mean BP of at least 5–6 measurements is the most informative for the diagnosis of arterial hypertension. The relationship of high BP variability with the severity of hypertension and the development of target organ damage was indicated. Variability of blood pressure changes on the background of antihypertensive therapy, namely increases while taking short-acting drugs. The article presents systematic reviews and meta-analyzes data concerning the mechanisms of formation, methods of determination and prognostic significance of BP variability

Prophylaxis of cognitive deficiency while performing еndarterectomy in patients, suffering stenotic affections of carotid arteries: the role of multidisciplinary approach

Вивчена ефективність профілактики когнітивного дефіциту у хворих за стенотичного ураження сонних артерій. Застосування інтраопераційної нейропротекції з використанням неотону дозволило зменшити частоту проявів реперфузійного синдрому з 35,6 до 3,4%, а також рівень когнітивного дефіциту. При цьому загальний ризик виникнення інтраопераційних або ранніх післяопераційних ускладнень знижувався. Для забезпечення належної якості клінічного моніторингу стану когнітивних функцій доцільне застосування принципів мультидисциплінарного підходу.Efficacy of the cognitive deficiency prophylaxis was studied in patients, suffering stenotic affection of carotid arteries. Application of intraoperative neuroprotection, using neoton, have permitted to reduce the reperfusion syndrome signs rate from 35.6 to 3.4%, аnd the cognitive deficiency level as well, causing the general occurrence risk of intraoperative or early morbidity lowering. It is expedient to apply the multidisciplinary approach for guaranteeing of adequate quality of clinical monitoring for cognitive functions

Accumulation of 90Sr by the representatives of pray fish in water basins of Chornobyl exclusion zone and other water basins of Ukraine

The results of studies of radioactive contamination of fishes’ organs and tissues of different ecological groups in water basins within the Chоrnobyl exclusion zone and other water basins of Kyiv region & Pokuttya have presented. During last years a continuing decrease of 90Sr specific activity in ichthyofauna representatives of all Ukrainian water basins was registered. The exception are the pray fish species of closed water basins of the Chоrnobyl exclusion zone where the 90Sr content remains at a certain high level. It is shown, that 90Sr for present time is the main dose-formed radionuclide for fish of the majority of water bodies within the Chornobyl exclusion zone

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release

International audienc