Statistical Properties of High-Speed Train Wireless Channels in Different Scenarios

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.In this paper, we compare the statistical properties of high-speed train (HST) wireless channels in different scenarios using a generic non-stationary HST channel model that has been verified by channel measurements (Ghazal et al., 2015). We mainly focus our comparison and analysis on the three most common HST scenarios, i.e., the rural area, cutting, and viaduct scenarios. Several channel statistical properties such as the temporal autocorrelation function (ACF), space cross-correlation function (CCF), and space- Doppler (SD) power spectrum density (PSD) are investigated. The impacts of different scenario- specific parameters on the channel statistical properties are also studied via numerical analysis

Channel Measurements and Models for High-Speed Train Wireless Communication Systems in Tunnel Scenarios: A Survey

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.The rapid developments of high-speed trains (HSTs) introduce new challenges to HST wireless communication systems. Realistic HST channel models play a critical role in designing and evaluating HST communication systems. Due to the length limitation, bounding of tunnel itself, and waveguide effect, channel characteristics in tunnel scenarios are very different from those in other HST scenarios. Therefore, accurate tunnel channel models considering both large-scale and small-scale fading characteristics are essential for HST communication systems. Moreover, certain characteristics of tunnel channels have not been investigated sufficiently. This article provides a comprehensive review of the measurement campaigns in tunnels and presents some tunnel channel models using various modeling methods. Finally, future directions in HST tunnel channel measurements and modeling are discussed

Study on evolution law of mechanical properties of coal samples subjected to freezing and freeze-thaw cycles of liquid nitrogen

The permeability of coal reservoir is generally low in China, how to effectively improve the permeability of coal reservoir is a key and difficult point of coalbed methane exploitation, Liquid nitrogen fracturing technology as a kind waterless fracturing technology has received extensive attention in recent years. In order to reveal the influence of liquid nitrogen freezing and freeze-thaw on the mechanical properties of coal, the temperature distribution of coal samples was monitored by infrared thermal imaging technology, and uniaxial compression and acoustic emission tests were performed on the coal samples after the liquid nitrogen freezing and freezethaw, the P-wave velocity, porosity, acoustic emission and energy evolution characteristics of coal samples before and after the freezing and freeze thaw were analyzed. The research result showed that: ①After 360 min freezing and 12 freeze-thaw cycles, the P-wave velocity of coal samples decreased by 58.2% and 64.7%, respectively. The P-wave velocity does not decrease significantly during the initial freezing and freeze-thaw cycle stages, the velocity gradually decreases with the increase of freezing time and freeze-thaw cycles. ②The temperature of the coal sample gradually decreases with increase of freezing times. The surface temperature of the coal sample drops below -60°C after the liquid nitrogen frozen for 180s, the temperature distribution fluctuations at the center of the coal sample occurs due to the different thermal conduction coefficient of the coal particles. ③After liquid nitrogen freezing and freezethaw, the elastic modulus of coal sample decreases exponentially, while the porosity gradually increases. The increase in porosity of the coal sample after liquid nitrogen freeze-thaw is greater than that after liquid nitrogen freezing. ④The acoustic emission activity of coal samples during uniaxial loading is divided into development phase, active phase and severe phase, the maximum acoustic emission ringing count and cumulative acoustic emission ringing count of coal samples increase with the increase of freezing time and freeze-thaw cycles. ⑤Liquid nitrogen freezing and freeze-thaw will weaken the energy storage limit of coal sample, resulting in the reduction of the total energy, elastic energy and dissipated energy at the peak point during the uniaxial loading process

High throughput Single-cell Cultivation on Microfluidic Streak Plates

This paper describes the microfluidic streak plate (MSP), a facile method for high-throughput microbial cell separation and cultivation in nanoliter sessile droplets. The MSP method builds upon the conventional streak plate technique by using microfluidic devices to generate nanoliter droplets that can be streaked manually or robotically onto petri dishes prefilled with carrier oil for cultivation of single cells. In addition, chemical gradients could be encoded in the droplet array for comprehensive dose-response analysis. The MSP method was validated by using single-cell isolation of Escherichia coli and antimicrobial susceptibility testing of Pseudomonas aeruginosa PAO1. The robustness of the MSP work flow was demonstrated by cultivating a soil community that degrades polycyclic aromatic hydrocarbons. Cultivation in droplets enabled detection of the richest species diversity with better coverage of rare species. Moreover, isolation and cultivation of bacterial strains by MSP led to the discovery of several species with high degradation efficiency, including four Mycobacterium isolates and a previously unknown fluoranthene-degrading Blastococcus species

Cobicistat Versus Ritonavir as a Pharmacoenhancer of Atazanavir Plus Emtricitabine/Tenofovir Disoproxil Fumarate in Treatment-Naive HIV Type 1-Infected Patients: Week 48 Results

Background. Cobicistat (COBI) is a pharmacoenhancer with no antiretroviral activity in vitro. Methods. An international, randomized, double-blind, double-dummy, active-controlled trial was conducted to evaluate the efficacy and safety of COBI versus ritonavir (RTV) as a pharmacoenhancer of atazanavir (ATV) in combination with emtricitabine (FTC)/tenofovir disoproxil fumarate (TDF) in treatment-naive patients. The primary end point was a human immunodeficiency virus type 1 (HIV-1) RNA load of 100 000 copies/mL, rates were similar (86% vs 86%). Similar percentages of patients in both groups had serious adverse events (10% of COBI recipients vs 7% of RTV recipients) and adverse events leading to discontinuation of treatment with the study drug (7% vs 7%). Median increases in the serum creatinine level were 0.13 and 0.09 mg/dL, respectively, for COBI and RTV recipients. Conclusions. COBI was noninferior to RTV in combination with ATV plus FTC/TDF at week 48. Both regimens achieved high rates of virologic success. Safety and tolerability profiles of the 2 regimens were comparable. Once-daily COBI is a safe and effective pharmacoenhancer of the protease inhibitor ATV. Clinical Trials Registration. NCT0110851

Biochemical Characterization and Function of Eight Microbial Type Terpene Synthases from Lycophyte Selaginella moellendorffii

Selaginella moellendorffii is a lycophyte, a member of an ancient vascular plant lineage. Two distinct types of terpene synthase (TPS) genes were identified from this species, including S. moellendorffii TPS genes (SmTPSs) and S. moellendorffii microbial TPS-like genes (SmMTPSLs). The goal of this study was to investigate the biochemical functions of SmMTPSLs. Here, eight full-length SmMTPSL genes (SmMTPSL5, -15, -19, -23, -33, -37, -46, and -47) were functionally characterized from S. moellendorffii. Escherichia coli-expressed recombinant SmMTPSLs were tested for monoterpenes synthase and sesquiterpenes synthase activities. These enzymatic products were typical monoterpenes and sesquiterpenes that have been previous shown to be generated by typical plant TPSs when provided with geranyl diphosphate (GPP) and farnesyl diphosphate (FPP) as the substrates. Meanwhile, SmMTPSL23, -33, and -37 were up-regulated when induced by alamethicin (ALA) and methyl jasmonate (MeJA), suggesting a role for these genes in plants response to abiotic stresses. Furthermore, this study pointed out that the terpenoids products of SmMTPSL23, -33, and -37 have an antibacterial effect on Pseudomonas syringae pv. tomato DC3000 and Staphylococcus aureus. Taken together, these results provide more information about the catalytic and biochemical function of SmMTPSLs in S. moellendorffii plants

Biochemical Characterization and Function of Eight Microbial Type Terpene Synthases from Lycophyte <i>Selaginella moellendorffii</i>

Selaginella moellendorffii is a lycophyte, a member of an ancient vascular plant lineage. Two distinct types of terpene synthase (TPS) genes were identified from this species, including S. moellendorffii TPS genes (SmTPSs) and S. moellendorffii microbial TPS-like genes (SmMTPSLs). The goal of this study was to investigate the biochemical functions of SmMTPSLs. Here, eight full-length SmMTPSL genes (SmMTPSL5, -15, -19, -23, -33, -37, -46, and -47) were functionally characterized from S. moellendorffii. Escherichia coli-expressed recombinant SmMTPSLs were tested for monoterpenes synthase and sesquiterpenes synthase activities. These enzymatic products were typical monoterpenes and sesquiterpenes that have been previous shown to be generated by typical plant TPSs when provided with geranyl diphosphate (GPP) and farnesyl diphosphate (FPP) as the substrates. Meanwhile, SmMTPSL23, -33, and -37 were up-regulated when induced by alamethicin (ALA) and methyl jasmonate (MeJA), suggesting a role for these genes in plants response to abiotic stresses. Furthermore, this study pointed out that the terpenoids products of SmMTPSL23, -33, and -37 have an antibacterial effect on Pseudomonas syringae pv. tomato DC3000 and Staphylococcus aureus. Taken together, these results provide more information about the catalytic and biochemical function of SmMTPSLs in S. moellendorffii plants

Research on the simulation modelling of high-voltage switchgear ring-shaped spring contact force

In order to explore the simulation method of the contact force for the ring-shaped spring and provide the support for the design of high-voltage switchgear-rated current and mechanical operating power, the parametric equation was derived, based on NX software the three-dimensional model was built, considering the influence of contact, friction, and large deformation, the non-linear dynamic finite element simulation model for the process of assembling and operating was established, the stress, resistance force, and friction force at any moment were obtained by simulation, and the variation of resistance and friction force during contact insertion was analysed. The results show that during the mechanical operating process, the resistance force rapidly increased to the extreme value and then gradually decreased to a stable value of 238N, and the friction force quickly increased and then slowly rose to the steady value of 238N, which is consistent with the experience and proved the rationality of the simulation model. Finally, according to the Coulomb friction law, the contact force of the spring contact was calculated as 1190N

A Planar π‑Conjugated Naphthyridine-Based N‑Heterocyclic Carbene Ligand and Its Derived Transition-Metal Complexes

HL·(PF₆) (L = 2,4-dimethyl-8-phenyl­[1,2,4]­triazolo­[4,3-<i>a</i>]­[1,8]­naphthyridin-9-ylidene) was synthesized from the nucleophilic reaction of 7-chloro-2,4-dimethyl-1,8-naphthyridine with phenylhydrazine and subsequent acidification, anion exchange, and condensation with triethyl orthoformate. Its silver, copper, cobalt, and nickel complexes [Ag₂(L)₂(CH₃CN)₂]­(PF₆)₂ (<b>1</b>), [CuL­(CH₃CN)₂]­(PF₆) (<b>2</b>), [CuL­(phen)]­(PF₆) (<b>3</b>), [CuL­(dppe)]­(PF₆) (<b>4</b>), [Co­(L)₂(CH₃CN)₂]­(PF₆)₂ (<b>5</b>), and [Ni­(L)₃]­(PF₆)₂ (<b>6</b>) have been synthesized and fully characterized by NMR, elemental analysis, and X-ray diffraction analysis. The copper complex <b>2</b> exhibits excellent catalytic activity in the Cu­(I)-catalyzed azide–alkyne cycloaddition reaction of 2,2,6,6-tetramethylpiperidinyl-1-oxy-tethered alkynes in an air atmosphere at 50 °C