1,270 research outputs found
Freeze-in Dirac neutrinogenesis: thermal leptonic CP asymmetry
We present a freeze-in realization of the Dirac neutrinogenesis in which the
decaying particle that generates the lepton-number asymmetry is in thermal
equilibrium. As the right-handed Dirac neutrinos are produced non-thermally,
the lepton-number asymmetry is accumulated and partially converted to the
baryon-number asymmetry via the rapid sphaleron transitions. The necessary
CP-violating condition can be fulfilled by a purely thermal kinetic phase from
the wavefunction correction in the lepton-doublet sector, which has been
neglected in most leptogenesis-based setup. Furthermore, this condition
necessitates a preferred flavor basis in which both the charged-lepton and
neutrino Yukawa matrices are non-diagonal. To protect such a proper Yukawa
structure from the basis transformations in flavor space prior to the
electroweak gauge symmetry breaking, we can resort to a plethora of model
buildings aimed at deciphering the non-trivial Yukawa structures.
Interestingly, based on the well-known tri-bimaximal mixing with a minimal
correction from the charged-lepton or neutrino sector, we find that a
simultaneous explanation of the baryon-number asymmetry in the Universe and the
low-energy neutrino oscillation observables can be attributed to the mixing
angle and the CP-violating phase introduced in the minimal correction.Comment: 28 pages and 7 figures; more discussions and one figure added, final
version published in the journa
The upper and lower solution method for nonlinear third-order three-point boundary value problem
This paper is concerned with the following nonlinear third-order three-point boundary value problem
\left\{
\begin{array}{l}
u^{\prime \prime \prime }(t)+f\left( t,u\left( t\right) ,u^{\prime}\left(t\right) \right) =0,\, t\in \left[ 0,1\right], \\
u\left( 0\right) =u^{\prime }\left( 0\right) =0,\, u^{\prime}\left( 1\right) =\alpha u^{\prime }\left( \eta \right),\label{1.1}
\end{array}
\right.
where and A new maximum principle is established and some existence criteria are obtained for the above problem by using the upper and lower solution method
Two variants on T2DM susceptible gene HHEX are associated with CRC risk in a Chinese population
Increasing amounts of evidence has demonstrated that T2DM (Type 2 Diabetes Mellitus) patients have increased susceptibility to CRC (colorectal cancer). As HHEX is a recognized susceptibility gene in T2DM, this work was focused on two SNPs in HHEX, rs1111875 and rs7923837, to study their association with CRC. T2DM patients without CRC (T2DM-only, n=300), T2DM with CRC (T2DM/CRC, n=135), cancer-free controls (Control, n=570), and CRC without T2DM (CRC-only, n=642) cases were enrolled. DNA samples were extracted from the peripheral blood leukocytes of the patients and sequenced by direct sequencing. The χ(2) test was used to compare categorical data. We found that in T2DM patients, rs1111875 but not the rs7923837 in HHEX gene was associated with the occurrence of CRC (p= 0.006). for rs1111875, TC/CC patients had an increased risk of CRC (p=0.019, OR=1.592, 95%CI=1.046-2.423). Moreover, our results also indicated that the two variants of HEEX gene could be risk factors for CRC in general population, independent on T2DM (p< 0.001 for rs1111875, p=0.001 for rs7923837). For rs1111875, increased risk of CRC was observed in TC or TC/CC than CC individuals (p<0.001, OR= 1.780, 95%CI= 1.385-2.287; p<0.001, OR= 1.695, 95%CI= 1.335-2.152). For rs7923837, increased CRC risk was observed in AG, GG, and AG/GG than AA individuals (p< 0.001, OR= 1.520, 95%CI= 1.200-1.924; p=0.036, OR= 1.739, 95%CI= 0.989-3.058; p< 0.001, OR= 1.540, 95%CI= 1.225-1.936). This finding highlights the potentially functional alteration with HHEX rs1111875 and rs7923837 polymorphisms may increase CRC susceptibility. Risk effects and the functional impact of these polymorphisms need further validation
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Linezolid and Rifampicin Combination to Combat cfr-Positive Multidrug-Resistant MRSA in Murine Models of Bacteremia and Skin and Skin Structure Infection.
Linezolid resistance mediated by the cfr gene in MRSA represents a global concern. We investigated relevant phenotype differences between cfr-positive and -negative MRSA that contribute to pathogenesis, and the efficacy of linezolid-based combination therapies in murine models of bacteremia and skin and skin structure infection (SSSI). As a group, cfr-positive MRSA exhibited significantly reduced susceptibilities to the host defense peptides tPMPs, human neutrophil peptide-1 (hNP-1), and cathelicidin LL-37 (P < 0.01). In addition, increased binding to fibronectin (FN) and endothelial cells paralleled robust biofilm formation in cfr-positive vs. -negative MRSA. In vitro phenotypes of cfr-positive MRSA translated into poor outcomes of linezolid monotherapy in vivo in murine bacteremia and SSSI models. Importantly, rifampicin showed synergistic activity as a combinatorial partner with linezolid, and the EC50 of linezolid decreased 6-fold in the presence of rifampicin. Furthermore, this combination therapy displayed efficacy against cfr-positive MRSA at clinically relevant doses. Altogether, these data suggest that the use of linezolid in combination with rifampicin poses a viable therapeutic alternative for bacteremia and SSSI caused by cfr-positive multidrug resistant MRSA
Scotogenic Dirac neutrino model embedded with leptoquarks: one pathway to addressing all
If the leptoquarks proposed to account for the intriguing anomalies observed
in the -meson decays, and , as well as in
the anomalous magnetic moment of the muon, , can be embedded into
the scotogenic Dirac neutrino model, all these flavor anomalies, together with
the origin of neutrino masses and the nature of dark matter, would be
potentially addressed in a unified picture. Among the minimal seesaw, one-loop,
and two-loop realizations of the dimension-4 effective operator
for the Dirac neutrino masses, we show that plenty of
diagrams associated with the two-loop realizations of can
support the coexistence of leptoquarks and dark matter candidates. After a
simple match of these leptoquarks to those that can accommodate all the flavor
anomalies, we establish the scotogenic Dirac neutrino models embedded with
leptoquarks, which could address all the problems mentioned above.Comment: 17 pages, 16 tables, 9 figure
Apocynin Improves Insulin Resistance through Suppressing Inflammation in High-Fat Diet-Induced Obese Mice
We investigated the effects of apocynin on high-fat diet- (HFD-) induced insulin resistance in C57BL/6 mice. After 12 weeks of HFD, the mice that exhibited insulin resistance then received 5 weeks of apocynin (2.4 g/L, in water). Following apocynin treatment, fasting glucose, insulin, and glucose tolerance test showed significant improvement in insulin sensitivity in HFD-fed mice. We demonstrated that serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and leptin were remarkably reduced with apocynin treatment. We also found that mRNA expression of TNF-α, IL-6, and monocyte chemoattractant protein-1 (MCP-1) in the liver and mRNA expression of TNF-α, IL-6, MCP-1, and leptin in adipose tissue were suppressed by apocynin. Furthermore, the activity of transcription factor NF-κB in the liver was significantly suppressed with apocynin treatment. These results suggest that apocynin may reduce inflammatory factors in the blood, liver, and adipose tissue, resulting in amelioration of insulin resistance in HFD-fed mice
Molecular docking studies on rocaglamide, a traditional Chinese medicine for periodontitis
Purpose: To undertake an in silico assessment of rocaglamide as a potential drug therapy forperiodontitis (dental arthritis).Method: Lamarckian algorithm-based automated docking approach using AutoDock4.2 tool wasapplied for calculating the best possible binding mode of rocaglamide to IL-23p19 and IL-17, the targets of anti-inflammatory drugs in periodontal disease.Results: The top two interactions of rocaglamide with IL-17 (ΔG = -5.45 and -4.83 kcal/mol) were more spontaneous, and the physical interactions (two hydrogen bonds and one π-πbond) generated in the two IL-17- rocaglamide complexes were higher in number than in IL-23p14-rocaglamide complexes.Conclusion: In silico analysis of rocaglamide, a known antimicrobial and anti-inflammatory agent, is a promising natural candidate for periodontitis therapy, and should be further subjected to in vitro and in vivo anti-periodontitis investigations.Keywords: Periodontitis, Inflammation, Rocaglamide, Molecular docking, Lamarckian algorithm, IL- 23p19, IL-1
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