The Neutral Hydrogen Distribution in Merging Galaxies: Differences between Stellar and Gaseous Tidal Morphologies

We have mapped the neutral atomic gas (HI) in the three disk-disk merger systems NGC 520, Arp 220, and Arp 299. These systems differ from the majority of the mergers mapped in HI, in that their stellar and gaseous tidal features do not coincide. In particular, they exhibit large stellar tidal features with little if any accompanying neutral gas and large gas-rich tidal features with little if any accompanying starlight. On smaller scales, there are striking anti-correlations where the gaseous and stellar tidal features appear to cross. We explore several possible causes for these differences, including dust obscuration, ram pressure stripping, and ionization effects. No single explanation can account for all of the observed differences. The fact that each of these systems shows evidence for a starburst driven superwind expanding in the direction of the most striking anti-correlations leads us to suggest that the superwind is primarily responsible for the observed differences, either by sweeping the features clear of gas via ram pressure, or by excavating a clear sightline towards the starburst and allowing UV photons to ionize regions of the tails.Comment: 16 pages, 5 figures, uses emulateapj.sty. To appear in the March 2000 issue of AJ. Version with full resolution figures is available via http://www.cv.nrao.edu/~jhibbard/HIdisp/HIdisp.htm

The dynamic dipole polarizabilities of the Li atom and the Be+ ion

The dynamic dipole polarizabilities for the Li atom and the Be+ ion in the 2s and 2p states are calculated using the variational method with a Hylleraas basis. The present polarizabilities represent the definitive values in the non-relativistic limit. Corrections due to relativistic effects are also estimated. Analytic representations of the polarizabilities for frequency ranges encompassing the n=3 excitations are presented. The recommended polarizabilities for ^7Li and ^9Be+ were 164.11 \pm 0.03 a.u. and 24.489 \pm 0.004 a.u.

False vacuum decay in Jordan-Brans-Dicke cosmologies

The bubble nucleation rate in a first-order phase transition taking place in a background Jordan-Brans-Dicke cosmology is examined. The leading order terms in the nucleation rate when the Jordan-Brans-Dicke field is large (i.e., late times) are computed by means of a Weyl rescaling of the fields in the theory. It is found that despite the fact that the Jordan-Brans-Dicke field (hence the effective gravitational constant) has a time dependence in the false vacuum at late times the nucleation rate is time independent

Wavelength-swept Tm-doped fiber laser operating in the two-micron wavelength band

A wavelength-swept thulium-doped silica fiber laser using an intracavity rotating slotted-disk wavelength scanning filter in combination with an intracavity solid etalon for passive control of temporal and spectral profiles is reported. The laser yielded a wavelength swept output in a step-wise fashion with each laser pulse separated from the previous pulse by a frequency interval equal to the free-spectral-range of the etalon and with an instantaneous linewidth of <0.05 nm. Scanning ranges from 1905 nm to 2049 nm for a cladding-pumping laser configuration, and from 1768 nm to 1956 nm for a core-pumping laser configuration were achieved at average output powers up to ~1 W

Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release

The SNARE-binding protein complexin (Cpx) has been demonstrated to regulate synaptic vesicle fusion. Previous studies are consistent with Cpx functioning either as a synaptic vesicle fusion clamp to prevent premature exocytosis, or as a facilitator to directly stimulate release. Here we examined conserved roles of invertebrate and mammalian Cpx isoforms in the regulation of neurotransmitter release using the Drosophila neuromuscular junction as a model synapse. We find that SNARE binding by Cpx is required for its role as a fusion clamp. All four mammalian Cpx proteins (mCpx), which have been demonstrated to facilitate release, also function as fusion clamps when expressed in Drosophila cpx null mutants, though their clamping abilities vary between isoforms. Moreover, expression of mCpx I, II or III isoforms dramatically enhance evoked release compared to mCpx IV or Drosophila Cpx. Differences in the clamping and facilitating properties of complexin isoforms can be partially attributed to differences in the C-terminal membrane tethering domain. Our findings indicate that the function of complexins as fusion clamps and facilitators of fusion are conserved across evolution, and that these roles are genetically separable within an isoform and across different isoforms.National Institutes of Health (U.S.) (NIH Grant NS064750)National Institutes of Health (U.S.) (NIH Grant NS40296

GeneFishing to reconstruct context specific portraits of biological processes.

Rapid advances in genomic technologies have led to a wealth of diverse data, from which novel discoveries can be gleaned through the application of robust statistical and computational methods. Here, we describe GeneFishing, a semisupervised computational approach to reconstruct context-specific portraits of biological processes by leveraging gene-gene coexpression information. GeneFishing incorporates multiple high-dimensional statistical ideas, including dimensionality reduction, clustering, subsampling, and results aggregation, to produce robust results. To illustrate the power of our method, we applied it using 21 genes involved in cholesterol metabolism as "bait" to "fish out" (or identify) genes not previously identified as being connected to cholesterol metabolism. Using simulation and real datasets, we found that the results obtained through GeneFishing were more interesting for our study than those provided by related gene prioritization methods. In particular, application of GeneFishing to the GTEx liver RNA sequencing (RNAseq) data not only reidentified many known cholesterol-related genes, but also pointed to glyoxalase I (GLO1) as a gene implicated in cholesterol metabolism. In a follow-up experiment, we found that GLO1 knockdown in human hepatoma cell lines increased levels of cellular cholesterol ester, validating a role for GLO1 in cholesterol metabolism. In addition, we performed pantissue analysis by applying GeneFishing on various tissues and identified many potential tissue-specific cholesterol metabolism-related genes. GeneFishing appears to be a powerful tool for identifying related components of complex biological systems and may be used across a wide range of applications