A generalized algorithm for fast two-dimensional angle estimation of a single source with uniform circular arrays

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Peer Support Group Health Literacy Case Study of HIVAIDS Patients in Karawang, Indonesia

The high mortality rate caused by HIV still leaves jobs for governments in developing countries, including in Indonesia; the government\u27s efforts to reduce the death rate due to HIV certainly require support and community participation. Peer support groups were born as a form of community concern to complete and carry out health literacy to the community, both those affected by HIV and those who are not well literate about HIV. This study aims to see the communication activities carried out by members of peer support groups to patients infected with HIV and how peer support groups\u27 efforts to carry out health literacy for HIV patients and the surrounding community. This research uses a case study approach that begins with what and how questions to form a scientific narrative of a case. This study\u27s findings are that peer support groups carry out communication activities in the form of support when receiving test results from HIV-infected patients, creating mentoring groups to increase the self-potential of their members, literacy, and mentoring healthy lifestyles for group members. Peer support groups are also conducting various collaborations with the local government to conduct outreach and cooperation to prove that HIV-infected patients can live an everyday life

Enhancing resilience by reducing critical load loss via an emergent trading framework considering possible resources isolation under typhoon

Leveraging distributed resources to enhance distribution network (DN) resilience is an effective measure in response to natural disasters. However, the willingness and economy of distributed resources are typically ignored. To address this issue, this paper proposes an emergent trading framework that uses parking lots (PLs) as resources to provide power support to critical loads (CLs) in a blackout due to typhoons. In this trading framework, an evolutionary Stackelberg game-based trading model is established to consider maximizing all stakeholders' economic benefits, considering possible resources isolation under typical fault scenarios caused by typhoons, and a benefit allocation mechanism is proposed for all stakeholders to motivate all stakeholders to participate in the trading. This framework allows that critical loads could reduce their load loss, parking lots could receive adequate compensation to stimulate them to participate in the trading, and distribution utility could ensure its economic benefits. Furthermore, an iterative evolutionary-Stackelberg solution set-up is applied to obtain the equilibria of the proposed framework. Simulation results on the modified IEEE 69-bus test system and IEEE 123-bus test system reveal the validity of the proposed method

Adaptive subspace sampling for class imbalance processing

© 2016 IEEE. This paper presents a novel oversampling technique that addresses highly imbalanced data distribution. At present, the imbalanced data that have anomalous class distribution and underrepresented data are difficult to deal with through a variety of conventional machine learning technologies. In order to balance class distributions, an adaptive subspace self-organizing map (ASSOM) that combines the local mapping scheme and globally competitive rule is proposed to artificially generate synthetic samples focusing on minority class samples. The ASSOM is conformed with feature-invariant characteristics, including translation, scaling and rotation, and it retains the independence of basis vectors in each module. Specifically, basis vectors generated via each ASSOM module can avoid generating repeated representative features that offer nothing but heavy computational load. Several experimental results demonstrate that the proposed ASSOM method with supervised learning manner is superior to other existing oversampling techniques

Full Length Research Paper Curcumin induces cleavage of -catenin by activation of capases and downregulates the &#946-catenin/Tcf signaling pathway in HT-29 cells

β-Catenin/Tcf-4 signaling pathway plays important roles in colorectal tumorigenesis. RT-PCR, western blotting and immunoprecipitation were used to study the effects of curcumin on β-catenin/Tcf-4 signaling pathway in HT-29 cells. Treatment of curcumin could induce cleavage of β-catenin and the cleavage could be inhibited by caspase inhibitors. The association of β-catenin with Tcf-4 in nucleus could be inhibited by curcumin. The expression of c-myc and cyclinD1 was downregulated by curcumin, which could not be blocked by Z-DEVD-FMK. The results showed curcumin could induce thecleavage of β-catenin by activition of caspases and downregulate the activity of β-catenin/Tcf signaling pathway independent of the caspases in HT-29 cells

Functional antioxidant and tyrosinase inhibitory properties of extracts of Taiwanese pummelo (Citrus grandis Osbeck)

In recent years, the overproduction of citrus fruits has resulted in an unnecessary increase in agricultural wastes in Taiwan. In an attempt to find an application for these potentially valuable wastes, we evaluated the antioxidant and whitening properties of six Taiwanese pummelo varieties (Miyu Shihtouyu Taipeiyu Touyu Wentan and Hsishihyu). The methanolic extract of Citrus grandis Osbeck Miyu (Miyu) had the highest phenolic content (9.99 mg of gallic acid equivalent/g). C. grandis Osbeck Shihtouyu (Shihtouyu) displayed the highest 2, 2-azino-bis-(3- ethylbenzthiazoline-6-sulfonic acid) content (9.3 mg trolox equivalent antioxidant content/g), indicating its good free radical-scavenging activity. C. grandis Osbeck Taipeiyu (Taipeiyu) showed the highest 1,1-diphenyl-2-picrylhydrazyl content and this compound too possesses good radical-scavenging activity. The ferrous-ion chelating effect of C. grandis Osbeck Touyu (Touyu) and C. grandis Osbeck Wentan (Wentan) was found to be 0.78 and 0.92 mg/ml, respectively. Taipeiyu showed the highest limonin content (1251.86 μg/ml). Touyu inhibited tyrosinase up to 90.8% (10 mg/ml), which was almost similar to the 95% inhibition shown by kojic acid (10 mg/ml). Thus, the components of pummelo have high potential for use as ingredients in products that prevent skin pigmentation. These results indicate that the methanolic extracts and the phytochemicals derived from pummelo are potential natural antioxidant agents.Key words: Antioxidant, free radical chelating, limonin, pummelo, tyrosinase

Fractional Anisotropy in Corpus Callosum Is Associated with Facilitation of Motor Representation during Ipsilateral Hand Movements

BACKGROUND: Coactivation of primary motor cortex ipsilateral to a unilateral movement (M1(ipsilateral)) has been observed, and the magnitude of activation is influenced by the contracting muscles. It has been suggested that the microstructural integrity of the callosal motor fibers (CMFs) connecting M1 regions may reflect the observed response. However, the association between the structural connectivity of CMFs and functional changes in M1(ipsilateral) remains unclear. The purpose of this study was to investigate the relationship between functional changes within M1(ipsilateral) during unilateral arm or leg movements and the microstructure of the CMFs connecting both homotopic representations (arm or leg). METHODS: Transcranial magnetic stimulation was used to assess changes in motor evoked potentials (MEP) in an arm muscle during unilateral movements compared to rest in fifteen healthy adults. Functional magnetic resonance imaging was then used to identify regions of M1 associated with either arm or leg movements. Diffusion-weighted imaging data was acquired to generate CMFs for arm and leg areas using the areas of activation from the functional imaging as seed masks. Individual values of regional fractional anisotropy (FA) of arm and leg CMFs was then calculated by examining the overlap between CMFs and a standard atlas of corpus callosum. RESULTS: The change in the MEP was significantly larger in the arm movement compared to the leg movement. Additionally, regression analysis revealed that FA in the arm CMFs was positively correlated with the change in MEP during arm movement, whereas a negative correlation was observed during the leg movement. However, there was no significant relationship between FA in the leg CMF and the change in MEP during the movements. CONCLUSIONS: These findings suggest that individual differences in interhemispheric structural connectivity may be used to explain a homologous muscle-dominant effect within M1(ipsilateral) hand representation during unilateral movement with topographical specificity

Relationship between depressive symptoms and capability to live well in people with mild to moderate dementia and their carers: results from the Improving the experience of Dementia and Enhancing Active Life (IDEAL) programme

This is the author accepted manuscript. The final version is available from the publisher via the DOI in this recordThe datasets generated and analysed during the current study are not publicly available due to the restrictions imposed in the original study but are available from the IDEAL study team on reasonable request.Objectives: Depression is a common condition in dementia and has a substantial impact on quality of life and wellbeing. There is limited evidence on how depressive symptoms in the person with dementia impact on the carer, and vice versa. The aim of this study is to investigate dyadic relationships between depressive symptoms and capability to live well in both people with dementia and their carers and to examine whether people with dementia who do not have a carer are more vulnerable to the impact of depressive symptoms than those who have a carer. Methods: Using a large cohort study of 1547 community-dwelling people with mild to moderate dementia and 1283 carers in Great Britain, a Bayesian analysis framework was developed to incorporate dyads (N = 981), people with dementia whose carers did not participate (N = 127), people with dementia who did not have a carer (N = 137), and dyads with missing data (N = 302) and estimate actor and partner relationships between depressive symptoms and capability to live well, which was expressed as a latent factor derived from measures of quality of life, life satisfaction and wellbeing. Results: Depressive symptoms in people with dementia and carers had negative associations with capability to live well both for the individual and for the partner. Compared to those who had a carer, depressive symptoms had a greater impact on capability to live well in people with dementia who did not had a carer. Conclusions: The impact of depression may extend beyond the person experiencing the symptoms. Future interventions for depressive symptoms should utilise this potential wider impact to understand and optimise treatment effects.Economic and Social Research Council (ESRC)National Institute for Health Research (NIHR

First two cases of living related liver transplantation with complicated anatomy of blood vessels in Beijing

Aim: Living related liver transplantation (LRLT) has been developed in response to the paediatric organ donor shortage. Though it has been succeeded in many centers worldwide, the safety of the donor is still a major concern, especially in donors with anatomy variation. We succeeded in performing the first two cases of living related liver transplantation with complicated anatomy of blood vessels as a way to overcome cadaveric organ shortage in Beijing. Methods: Two patients, with congenital liver fibrosis and congenital biliary atresia were performed with living donor liver transplantation in our hospital and then followed up from November 12 to December 13, 2001. The two living donors, mother and father, were healthy aged 34 and 35 years. One right lobe (segment V, VI, VII, VIII) and one left lateral lobe (segment II and III) were used. The grafts weighed 394 g and 300 g. The ratio of graff weight to the standard liver volume (SLV) of donors was 68% and 27%. The graft weight to recipient body weight ratio was 3.2% and 4.4%. The graft weight to recipient estimated standard liver mass (ESLM) ratio was 63% and 85%. The two donors had complicated blood vessel variation. Results: Two patients undergone living donor liver transplantation had good results. Abnormal liver function with high bilirubin level appeared in a few days after operation, bur liver function returned to normal one month after operation with bilirubin level almost decreased to near normal. No bleeding, thrombosis, infection and bile leakage occurred. One had an acure rejection and recovered. The two donors recovered in two weeks. One had slight fever because of a little collection in abdomen and recovered after paracentesis and drainage. Conclusion: Living donor liver transplantation has been proved to be a good way that offers a unique opportunity of getting a timely liver graft as a response to shortage of pediatric donors, though it could be a technically difficult operation if there is anatomical variation. Copyright © 2004 by The WJG Press.published_or_final_versio

Fuzzy Integral with Particle Swarm Optimization for a Motor-Imagery-Based Brain-Computer Interface

© 2016 IEEE. A brain-computer interface (BCI) system using electroencephalography signals provides a convenient means of communication between the human brain and a computer. Motor imagery (MI), in which motor actions are mentally rehearsed without engaging in actual physical execution, has been widely used as a major BCI approach. One robust algorithm that can successfully cope with the individual differences in MI-related rhythmic patterns is to create diverse ensemble classifiers using the subband common spatial pattern (SBCSP) method. To aggregate outputs of ensemble members, this study uses fuzzy integral with particle swarm optimization (PSO), which can regulate subject-specific parameters for the assignment of optimal confidence levels for classifiers. The proposed system combining SBCSP, fuzzy integral, and PSO exhibits robust performance for offline single-trial classification of MI and real-time control of a robotic arm using MI. This paper represents the first attempt to utilize fuzzy fusion technique to attack the individual differences problem of MI applications in real-world noisy environments. The results of this study demonstrate the practical feasibility of implementing the proposed method for real-world applications