MMX, The Next Generation of In-Situ Exploration Mission

The JAXA MMX (Martian Moons eXploration) mission has the objectives to study Phobos, the largest moon of Mars, and to bring back to Earth a sample from its surface, to answer one main question: what is the origin of the Martian moons? This mission will be launched in 2026 and will last five years. MMX spacecraft, the orbiter, developed by JAXA will travel from Earth to Mars and then study Phobos and Deimos moons with a foreseen sample collection of Phobos soil. MMX will carry and drop a small rover, developed by CNES and DLR, on Phobos surface. This rover, called Idefix, delivered close to the sample collection area will perform soil characterization in order to secure MMX spacecraft landing It\u27s designed to drive in very low gravity and low power availability for a hundred days, moving thanks to four wheels and carrying a couple of instruments to study Phobos composition. The electronic elements of the rover are in a nanosat size stack. CNES was in charge of most of the rover internal subsystems, the flight software, the mission analysis and thermal and mechanical architectures. DLR was in charge of the rover chassis, shutters, separation and locomotion systems. CNES and DLR share the system, operations and project lead. The RF communication between the rover and the orbiter is performed thanks to an intersatellite link using two S-band transponders. Their design is a heritage of the Rosetta-Philae mission combined to the needs brought by the nanosatellite markets. The article will present in a first part the development logic and the characteristics of these equipment. The communications during the mission will go through three different phases, each one associated to specific constraints. A second part of the article will focus on these phases and the impacts on the RF link. A third part will focus on the ISL qualifications, tests and measurements performed to comply with the mission and planning constraints

Dynamic Innate Immune Responses of Human Bronchial Epithelial Cells to Severe Acute Respiratory Syndrome-Associated Coronavirus Infection

Human lung epithelial cells are likely among the first targets to encounter invading severe acute respiratory syndrome-associated coronavirus (SARS-CoV). Not only can these cells support the growth of SARS-CoV infection, but they are also capable of secreting inflammatory cytokines to initiate and, eventually, aggravate host innate inflammatory responses, causing detrimental immune-mediated pathology within the lungs. Thus, a comprehensive evaluation of the complex epithelial signaling to SARS-CoV is crucial for paving the way to better understand SARS pathogenesis. Based on microarray-based functional genomics, we report here the global gene response of 2B4 cells, a cloned bronchial epithelial cell line derived from Calu-3 cells. Specifically, we found a temporal and spatial activation of nuclear factor (NF)κB, activator protein (AP)-1, and interferon regulatory factor (IRF)-3/7 in infected 2B4 cells at 12-, 24-, and 48-hrs post infection (p.i.), resulting in the activation of many antiviral genes, including interferon (IFN)-β, -λs, inflammatory mediators, and many IFN-stimulated genes (ISGs). We also showed, for the first time, that IFN-β and IFN-λs were capable of exerting previously unrecognized, non-redundant, and complementary abilities to limit SARS-CoV replication, even though their expression could not be detected in infected 2B4 bronchial epithelial cells until 48 hrs p.i. Collectively, our results highlight the mechanics of the sequential events of antiviral signaling pathway/s triggered by SARS-CoV in bronchial epithelial cells and identify novel cellular targets for future studies, aiming at advancing strategies against SARS

Hayabusa2’s superior solar conjunction mission operations: planning and post-operation results

Abstract In late 2018, the asteroid Ryugu was in the Sun’s shadow during the superior solar conjunction phase. As the Sun-Earth-Ryugu angle decreased to below 3°, the Hayabusa2 spacecraft experienced 21 days of planned blackout in the Earth-probe communication link. This was the first time a spacecraft had experienced solar conjunction while hovering around a minor body. For the safety of the spacecraft, a low energy transfer trajectory named Ayu was designed in the Hill reference frame to increase its altitude from 20 to 110 km. The trajectory was planned with the newly developed optNEAR tool and validated with real time data. This article shows the results of the conjunction operation, from planning to flight data.</jats:p

Sequence-specific error profile of Illumina sequencers

We identified the sequence-specific starting positions of consecutive miscalls in the mapping of reads obtained from the Illumina Genome Analyser (GA). Detailed analysis of the miscall pattern indicated that the underlying mechanism involves sequence-specific interference of the base elongation process during sequencing. The two major sequence patterns that trigger this sequence-specific error (SSE) are: (i) inverted repeats and (ii) GGC sequences. We speculate that these sequences favor dephasing by inhibiting single-base elongation, by: (i) folding single-stranded DNA and (ii) altering enzyme preference. This phenomenon is a major cause of sequence coverage variability and of the unfavorable bias observed for population-targeted methods such as RNA-seq and ChIP-seq. Moreover, SSE is a potential cause of false single-nucleotide polymorphism (SNP) calls and also significantly hinders de novo assembly. This article highlights the importance of recognizing SSE and its underlying mechanisms in the hope of enhancing the potential usefulness of the Illumina sequencers

On the origin and evolution of the asteroid Ryugu: A comprehensive geochemical perspective

Presented here are the observations and interpretations from a comprehensive analysis of 16 representative particles returned from the C-type asteroid Ryugu by the Hayabusa2 mission. On average Ryugu particles consist of 50% phyllosilicate matrix, 41% porosity and 9% minor phases, including organic matter. The abundances of 70 elements from the particles are in close agreement with those of CI chondrites. Bulk Ryugu particles show higher δ18O, Δ17O, and ε54Cr values than CI chondrites. As such, Ryugu sampled the most primitive and least-thermally processed protosolar nebula reservoirs. Such a finding is consistent with multi-scale H-C-N isotopic compositions that are compatible with an origin for Ryugu organic matter within both the protosolar nebula and the interstellar medium. The analytical data obtained here, suggests that complex soluble organic matter formed during aqueous alteration on the Ryugu progenitor planetesimal (several 10’s of km), <2.6 Myr after CAI formation. Subsequently, the Ryugu progenitor planetesimal was fragmented and evolved into the current asteroid Ryugu through sublimation

A pristine record of outer Solar System materials from asteroid Ryugu’s returned sample

Volatile and organic-rich C-type asteroids may have been one of the main sources of Earth’s water. Our best insight into their chemistry is currently provided by carbonaceous chondritic meteorites, but the meteorite record is biased: only the strongest types survive atmospheric entry and are then modified by interaction with the terrestrial environment. Here we present the results of a detailed bulk and microanalytical study of pristine Ryugu particles, brought to Earth by the Hayabusa2 spacecraft. Ryugu particles display a close compositional match with the chemically unfractionated, but aqueously altered, CI (Ivuna-type) chondrites, which are widely used as a proxy for the bulk Solar System composition. The sample shows an intricate spatial relationship between aliphatic-rich organics and phyllosilicates and indicates maximum temperatures of ~30 °C during aqueous alteration. We find that heavy hydrogen and nitrogen abundances are consistent with an outer Solar System origin. Ryugu particles are the most uncontaminated and unfractionated extraterrestrial materials studied so far, and provide the best available match to the bulk Solar System composition

A dehydrated space-weathered skin cloaking the hydrated interior of Ryugu

Without a protective atmosphere, space-exposed surfaces of airless Solar System bodies gradually experience an alteration in composition, structure and optical properties through a collective process called space weathering. The return of samples from near-Earth asteroid (162173) Ryugu by Hayabusa2 provides the first opportunity for laboratory study of space-weathering signatures on the most abundant type of inner solar system body: a C-type asteroid, composed of materials largely unchanged since the formation of the Solar System. Weathered Ryugu grains show areas of surface amorphization and partial melting of phyllosilicates, in which reduction from Fe3+ to Fe2+ and dehydration developed. Space weathering probably contributed to dehydration by dehydroxylation of Ryugu surface phyllosilicates that had already lost interlayer water molecules and to weakening of the 2.7 µm hydroxyl (–OH) band in reflectance spectra. For C-type asteroids in general, this indicates that a weak 2.7 µm band can signify space-weathering-induced surface dehydration, rather than bulk volatile loss

Reduced-gravity experiments of nonspherical rigid-body impact on hard surfaces

Ballistic landers enable orbiting asteroid missions to perform surface science at limited additional cost and risk. Due to asteroids’ weak gravity and irregular terrain, lander deployment trajectories will consist of several chaotic bounces. Although impacts on regolith-covered asteroids are numerically expensive to model, impacts on rocky asteroids can be modeled with simpler, impulsive contact models. One such model is that by Stronge, which was successfully used in large-scale Monte Carlo studies of asteroid lander deployment. This model parameterizes impacts with (fixed) material restitution and friction coefficients, but has not been validated for the low-velocity regime of an assembled, nonspherical body. This paper uses an air-bearing setup to perform 2D experiments of a rectangular floating assembly impacting a concrete block with cm/s. The impact velocity, assembly attitude, and block attitude are varied across 2,400 experimental runs of both normal and tangential impacts. Optical tracking is used to extract the pre- and post-impact velocities of the assembly. In a majority of cases, Stronge’s model can be fit to the experiments to extract the corresponding restitution and friction coefficients. We find that the coefficients are not fixed with respect to the impact velocity and attitude, but that their variation is seemingly random. In some tangential impact cases, the model even fails to reproduce the observed behavior althogether. This suggests that there may not be a simple way to reconcile Stronge’s fixed-material-coefficient model with reality, although it may retain practical use if the coefficients are randomly varied in each impact of a simulation