Inclusive SUSY Searches using Missing Energy plus Multijets in pp collisions at s\sqrt{s}=14 TeV with CMS

An inclusive analysis strategy for SUSY searches in pp collisions at sqrt(s)=14 TeV with the CMS detector is discussed. The missing transverse energy plus multijets canonical signature is used. Emphasis is put in methods to normalize the backgrounds using the data and in understanding the experimental systematic uncertainties. A 5 sigma excess can be observed with O(pb^-1) at a particular low mass SUSY point. The 5 sigma discovery reach contours in the mSUGRA parameter space for 1 and 10 fb^-1 are obtained

Using Jet Substructure at the LHC to Search for the Light Higgs Bosons of the CP-Violating MSSM

The CP-violating version of the Minimal Supersymmetric Standard Model (MSSM) is an example of a model where experimental data do not preclude the presence of light Higgs bosons in the range around 10 -- 110 GeV. Such light Higgs bosons, decaying almost wholly to b-bbar pairs, may be copiously produced at the LHC, but would remain inaccessible to conventional Higgs searches because of intractable QCD backgrounds. We demonstrate that a significant number of these light Higgs bosons would be boosted strongly enough for the pair of daughter $b$-jet pairs to appear as a single `fat' jet with substructure. Tagging such jets could extend the discovery potential at the LHC into the hitherto-inaccessible region for light Higgs bosons.Comment: LaTeX, 33 pages, 5 eps figures and 5 tables embedded. minor changes, to appear in Physical Review

Jet Fragmentation Functions Measured in PbPb Collisions with CMS

The energy loss of partons in high-energy nuclear collisions is one of the most interesting observables to probe the nature of the produced medium. Analyzing data from PbPb collisions at a center-of-mass energy of 2.76 TeV, recorded with the Compact Muon Solenoid (CMS) detector, parton energy loss is observed as a significant imbalance of dijet transverse momentum. To gain further understanding of the parton energy loss mechanism and how it manifests itself in the distribution of final state particles, fragmentation functions are studied for the leading and subleading jet in bins of dijet imbalance.Comment: 1 cover + 4 pages, 3 figures (with 5 source figures). Quark Matter 2011 conference report. To be published in special issue of J. Phys. G: Nucl. Part. Phy

The macaroni sign

A 41-year-old woman was referred to radiology department for the evaluation of sudden paresis in the left side. Brain magnetic resonance imaging (MRI) showed multiple bilateral ischemic regions in the watershed areas. Also, the brain magnetic resonance angiography (MRA) showed bilateral internal carotid artery (ICA) occlusions at the level of the cervical ICA region. Both vertebral arteries were found to be enlarged (arrow) and the retrograde filling of the anterior circulation was observed (Fig. A). For the investigation and the differentiation of the bilateral carotid lesions, the color Doppler ultrasonography was obtained. This study showed homogenous, hypoechoic, circumferential wall thickening of both distal common carotid artery arteries (CCA). The thickening of the arteries wall were like ‘Macaroni’. The wall thickness was 0.17 cm (Fig. B). The tapering of both CCA and total oclusion of both ICA were seen. The carotid MRA revealed collateral circulation from the subclavian arteries to the ECA and 50% stenosis of the left CCA (arrow) and 70% stenosis of the right CCA at its origin. Vertebral arteries were also prominant and there were 50% narrowing in the mid portion of the left subclavian artery (Fig. C). The radiological diagnosis of the Takayasu’s arteritis (TA) was made and the patient was referred to the rheumatology clinic for further diagnosis and work-up

Exact Solution of Photon Equation in Stationary G\"{o}del-type and G\"{o}del Space-Times

In this work the photon equation (massless Duffin-Kemmer-Petiau equation) is written expilicitly for general type of stationary G\"{o}del space-times and is solved exactly for G\"{o}del-type and G\"{o}del space-times. Harmonic oscillator behaviour of the solutions is discussed and energy spectrum of photon is obtained.Comment: 9 pages,RevTeX, no figure, revised for publicatio

Commissioning of the CMS zero degree calorimeter using LHC beam

This paper reports on the commissioning and first running experience of the CMS Zero Degree Calorimeters during December 2009. All channels worked correctly. The ZDCs were timed into the data acquisition system using beam splash events. These data also allowed us to make a first estimate of channel-by-channel variations in gain.Comment: 6 pages, 8 figures, Presented at CALOR2010: 14th International Conference for Calorimetry in High Energy Physic

Angiogenesis in gynecological cancers and the options for anti-angiogenesis therapy.

Angiogenesis is required in cancer, including gynecological cancers, for the growth of primary tumors and secondary metastases. Development of anti-angiogenesis therapy in gynecological cancers and improvement of its efficacy have been a major focus of fundamental and clinical research. However, survival benefits of current anti-angiogenic agents, such as bevacizumab, in patients with gynecological cancer, are modest. Therefore, a better understanding of angiogenesis and the tumor microenvironment in gynecological cancers is urgently needed to develop more effective anti-angiogenic therapies, either or not in combination with other therapeutic approaches. We describe the molecular aspects of (tumor) blood vessel formation and the tumor microenvironment and provide an extensive clinical overview of current anti-angiogenic therapies for gynecological cancers. We discuss the different phenotypes of angiogenic endothelial cells as potential therapeutic targets, strategies aimed at intervention in their metabolism, and approaches targeting their (inflammatory) tumor microenvironment

New Insights in ATP Synthesis as Therapeutic Target in Cancer and Angiogenic Ocular Diseases.

Lactate and ATP formation by aerobic glycolysis, the Warburg effect, is considered a hallmark of cancer. During angiogenesis in non-cancerous tissue, proliferating stalk endothelial cells (ECs) also produce lactate and ATP by aerobic glycolysis. In fact, all proliferating cells, both non-cancer and cancer cells, need lactate for the biosynthesis of building blocks for cell growth and tissue expansion. Moreover, both non-proliferating cancer stem cells in tumors and leader tip ECs during angiogenesis rely on glycolysis for pyruvate production, which is used for ATP synthesis in mitochondria through oxidative phosphorylation (OXPHOS). Therefore, aerobic glycolysis is not a specific hallmark of cancer but rather a hallmark of proliferating cells and limits its utility in cancer therapy. However, local treatment of angiogenic eye conditions with inhibitors of glycolysis may be a safe therapeutic option that warrants experimental investigation. Most types of cells in the eye such as photoreceptors and pericytes use OXPHOS for ATP production, whereas proliferating angiogenic stalk ECs rely on glycolysis for lactate and ATP production. (J Histochem Cytochem XX.XXX-XXX, XXXX)

Effect of iloprost on contractile impairment and mitochondrial degeneration in ischemia-reperfusion of skeletal muscle

Purpose Acute lower extremity ischemia is still a main cause of mortality and morbidity in orthopedic traumatology and reconstructive surgery. In acute lower extremity ischemia, the skeletal muscles are the tissues that are the most vulnerable to ischemia. The aim of this study was to evaluate the effects of iloprost (IL) therapy on skeletal muscle contractile impairment and mitochondrial degeneration in an acute lower extremity ischemia-reperfusion rat model. Main Methods Forty Wistar albino rats were randomly divided into a control group and four experimental groups. Experimental groups were either subjected to 2 h of lower extremity ischemia followed by a 4-h reperfusion period or to 4 h of ischemia followed by an 8-h reperfusion period. Except for the animals in the control group, all animals received IL (1 ng/kg/min) or saline (1 ml/kg) by intraperitoneal infusion for 10 min immediately before reperfusion. At the end of the recording of skeletal muscle electrical activity and contractility, all rats were sacrificed by decapitation and muscle samples of lower extremity were immediately harvested for histopathologic analyses. Results After ischemia-reperfusion, a breakdown in the force–frequency curves of extensor digitorum longus muscle was observed, showing the diminished muscle contractility. However, IL significantly improved muscle contractility following injury induced by 2 h of ischemia followed by a 4-h reperfusion period. In addition, IL partially ameliorated mitochondrial degeneration in the muscle cells of ischemia groups. Conclusion This study indicates that immediate IL therapy repairs muscle damage especially after 2 h of ischemia and 4 h of reperfusion and therefore that IL improves contractile function