Understanding organisational use of IT/IS for demand and supply chain management in a MNC pharmaceutical company

Demand supply chain management (DSCM), which integrates market segmentation with supply chain strategy supported by proper alignment in organizational configuration, is regarded by researchers as the next stage of evolution of supply chain management. Through an exploratory case study of the pharmaceutical industry, this study investigates the role of information systems / information technology (IS/IT) as an enabler of DSCM. The findings reveal that there is little alignment between IS and supply chain strategy even though technology is used widely in the company that is investigated. The lack of alignment has prevented the organisation from being DSCM capable. The study highlights the impacts of lack of alignment between IS and DSCM and helps practitioners understand the implications

Anti-jamming performance of chaotic digital communication systems

Author name used in this publication: F. C. M. LauAuthor name used in this publication: C. K. TseAuthor name used in this publication: S. F. Hau2002-2003 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Coexistence of chaos-based and conventional digital communication systems of equal bit rate

Author name used in this publication: Francis C. M. LauAuthor name used in this publication: Chi K. TseAuthor name used in this publication: Sau F. Hau2003-2004 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

A review of net zero energy buildings in hot and humid climates: Experience learned from 34 case study buildings

Sustainable development in the building sector requires the integration of energy efficiency and renewable energy utilization in buildings. In recent years, the concept of net zero energy buildings (NZEBs) has become a potential plausible solution to improve efficiency and reduce energy consumption in buildings. To achieve an NZEB goal, building systems and design strategies must be integrated and optimized based on local climatic conditions. This paper provides a comprehensive review of NZEBs and their current development in hot and humid regions. Through investigating 34 NZEB cases around the world, this study summarized NZEB key design strategies, technology choices and energy performance. The study found that passive design and technologies such as daylighting and natural ventilation are often adopted for NZEBs in hot and humid climates, together with other energy efficient and renewable energy technologies. Most NZEB cases demonstrated site annual energy consumption intensity less than 100 kW-hours (kWh) per square meter of floor space, and some buildings even achieved “net-positive energy” (that is, they generate more energy locally than they consume). However, the analysis also shows that not all NZEBs are energy efficient buildings, and buildings with ample renewable energy adoption can still achieve NZEB status even with high energy use intensity. This paper provides in-depth case-study-driven analysis to evaluate NZEB energy performance and summarize best practices for high performance NZEBs. This review provides critical technical information as well as policy recommendations for net zero energy building development in hot and humid climates

Adiponectin protects against paraquat-induced lung injury by attenuating oxidative/nitrative stress.

The specific mechanisms underlying paraquat (PQ)-induced lung injury remain unknown, which limits understanding of its cytotoxic potential. Although oxidative stress has been established as an important mechanism underlying PQ toxicity, multiple antioxidants have proven ineffective in attenuating the deleterious effects of PQ. Adiponectin, which shows anti-oxidative and antinitrative effects, may have the potential to reduce PQ-mediated injury. The present study determined the protective action of globular domain adiponectin (gAd) on PQ-induced lung injury, and attempted to elucidate the underlying mechanism or mechanisms of action. BALB/c mice were administered PQ, with and without 12 or 36 h of gAd pre-treatment. The pulmonary oxidative/nitrative status was assessed by measuring pulmonary O2(•-), superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO) and 8-hydroxy-2-dydeoxy guanosine (8-OHdG) production, and blood 3-Nitrotyrosine (3-NT). At a dose of 20 mg/kg, PQ markedly increased O2(•-), SOD, MDA, NO and 8-OHdG production 3 h post-administration, but did not significantly increase 3-NT levels until 12 h. gAd inhibited these changes in a dose-dependent manner, via transient activation of MDA, followed by attenuation of MDA formation from 6 h onwards. Histological analysis demonstrated that gAd decreased interstitial edema and inflammatory cell infiltration. These results suggest that gAd protects against PQ-induced lung injury by mitigating oxidative/nitrative stress. Furthermore, gAd may be a potential therapeutic agent for PQ-induced lung injury, and further pharmacological studies are therefore warranted