Specific Expression of Human Intelectin-1 in Malignant Pleural Mesothelioma and Gastrointestinal Goblet Cells

Malignant pleural mesothelioma (MPM) is a fatal tumor. It is often hard to discriminate MPM from metastatic tumors of other types because currently, there are no reliable immunopathological markers for MPM. MPM is differentially diagnosed by some immunohistochemical tests on pathology specimens. In the present study, we investigated the expression of intelectin-1, a new mesothelioma marker, in normal tissues in the whole body and in many cancers, including MPM, by immunohistochemical analysis. We found that in normal tissues, human intelectin-1 was mainly secreted from gastrointestinal goblet cells along with mucus into the intestinal lumen, and it was also expressed, to a lesser extent, in mesothelial cells and urinary epithelial cells. Eighty-eight percent of epithelioid-type MPMs expressed intelectin-1, whereas sarcomatoid-type MPMs, biphasic MPMs, and poorly differentiated MPMs were rarely positive for intelectin-1. Intelectin-1 was not expressed in other cancers, except in mucus-producing adenocarcinoma. These results suggest that intelectin-1 is a better marker for epithelioid-type MPM than other mesothelioma markers because of its specificity and the simplicity of pathological assessment. Pleural intelectin-1 could be a useful diagnostic marker for MPM with applications in histopathological identification of MPM

Research and Design of a Routing Protocol in Large-Scale Wireless Sensor Networks

无线传感器网络，作为全球未来十大技术之一，集成了传感器技术、嵌入式计算技术、分布式信息处理和自组织网技术，可实时感知、采集、处理、传输网络分布区域内的各种信息数据，在军事国防、生物医疗、环境监测、抢险救灾、防恐反恐、危险区域远程控制等领域具有十分广阔的应用前景。 本文研究分析了无线传感器网络的已有路由协议，并针对大规模的无线传感器网络设计了一种树状路由协议，它根据节点地址信息来形成路由，从而简化了复杂繁冗的路由表查找和维护，节省了不必要的开销，提高了路由效率，实现了快速有效的数据传输。 为支持此路由协议本文提出了一种自适应动态地址分配算——ADAR（AdaptiveDynamicAddre...As one of the ten high technologies in the future, wireless sensor network, which is the integration of micro-sensors, embedded computing, modern network and Ad Hoc technologies, can apperceive, collect, process and transmit various information data within the region. It can be used in military defense, biomedical, environmental monitoring, disaster relief, counter-terrorism, remote control of haz...学位：工学硕士院系专业：信息科学与技术学院通信工程系_通信与信息系统学号：2332007115216

A compact synchroscan streak camera using a microchannel plate incorporated tube

A compact synchroscan streak camera, which incorporates a microchannel plates providing a high light gain, has been constructed. The camera has been operated in synchronism with a synchronous-passive hybrid mode-locked CW dye laser, and the overall time resolution has been 10.8 and 25.9 ps for a recording of ～160 and ～ lO^[8] cycles of dye laser pulses, respectively. In addition, by using the camera system with the dye laser a weak fluorescence profile (a quantum yield of ～10^[-3]) of an important biomolecule has been directly observed on a picosecond time scale

Picosecond time-resolved fluorescence spectroscopy of hematoporphyrin derivative

The picosecond time-resolved fluorescence decays I(t) and spectra I(λ, t) for hematoporphyrin derivative (HPD) in a phosphate buffer saline aqueous solution at different concentrations (8.4 x 10^[-6] ～ 8.4 x 10^[-3] M) are measured by a two-dimensional synchroscan streak camera with a mode-locked CW dye laser, and a new emission band (which we call the Y-band) is found at high concentration. It is shown that the fluorescence decays composed of fast and slow components at high concentration are due to the Y-band (120 ps lifetime) from head-to-tail aggregates including equilibrium dimer and stable dimer, and the usual band (3.6 ns lifetime) from monomer, respectively, and the latter band is dynamically quenched by the Förster type resonance energy transfer from the monomer to the aggregate. Furthermore, the measurement of static fluorescence spectra from human gastric cancers and the surrounding in vivo after HPD injection shows that a band corresponding to the Y-band from the aggregate appears at only the cancerous cells

Picosecond time-resolved fluorescence spectroscopy of hematoporphyrin derivative

The picosecond time-resolved fluorescence decays I(t) and spectra I(λ, t) for hematoporphyrin derivative (HPD) in a phosphate buffer saline aqueous solution at different concentrations (8.4 x 10^[-6] ～ 8.4 x 10^[-3] M) are measured by a two-dimensional synchroscan streak camera with a mode-locked CW dye laser, and a new emission band (which we call the Y-band) is found at high concentration. It is shown that the fluorescence decays composed of fast and slow components at high concentration are due to the Y-band (120 ps lifetime) from head-to-tail aggregates including equilibrium dimer and stable dimer, and the usual band (3.6 ns lifetime) from monomer, respectively, and the latter band is dynamically quenched by the Förster type resonance energy transfer from the monomer to the aggregate. Furthermore, the measurement of static fluorescence spectra from human gastric cancers and the surrounding in vivo after HPD injection shows that a band corresponding to the Y-band from the aggregate appears at only the cancerous cells