Optimum design of hydrodynamic thrust bearings with rayleigh's pocket profiles

Optimum design problem for hydrodynamic self-aligning acting thrust bearings was considered. Based on results for rectangular region the problem for sector region was solved. As an objective function, the maximum of pressure integral over the lubricant layer surface was used and five geometrical parameters described Rayleigh's pocket shape were used as optimization variables during optimization procedure. The bearing pressure distribution was determined on the basis of the Navier-Stokes equations using the ANSYS / CFX software. Numerically the optimization problem was solved using three different methods: IOSO, SIMPLEX and pilOPT+AFilter SQP realized in two commercial optimization software IOSO and modeFRONTIER. The aim of this investigation was designing the technologically advanced profiles of thrust bearing sector microgeometry ensuring the maximum load capacity

Risk factors of postoperative cognitive dysfunction

This article analyzes the current understanding of the possible factors of postoperative cognitive deficits in patients of the hospital, as well as a method of diagnosis of this pathology in patients who have previously undergone surgery.В данной статье проанализированы современные представления о возможных факторах развития послеоперационного когнитивного дефицита у пациентов стационара, а также предложена методика диагностики данной патологии у пациентов стационара, ранее перенёсших оперативное вмешательство

Изменение климата и размеров ледников в горах Кузнецкого Алатау в 1975-2015 гг.

Climate change in the Kuznetsky Alatau (Western Siberia) highlands (on its eastern macroslope) was investigated using data of the Nenasthaya weather station collected for the last 40 years. It is the only highland station functioning now in the area under investigation. Basing on the correlation between average daily temperatures for the period 1974–1975, obtained at the Nenasthaya station and meteopost Karatash (located in front of the Kartash Glacier), we believe that the Nenasthaya one is enough representative for analysis of the climate in this glacio-nival zone. Linear trends for mean summer temperatures and annual precipitation sums had been calculated. Analysis of the linear trends has indicated that for the last 40 years the average summer temperature in the Kuznetsky Alatau increased by 1.3 °C with the growth rate of 0.33 °C/10 years. Average annual precipitation has also increased by 320 mm (the growth rate is 80 mm/10 years). These climatic changes did cause corresponding reactions of glaciers in the area. The analysis of current changes in the glacio-nival systems demonstrated that different morphological types of glaciers reacted to the current climate change in different ways. Small slope glaciers and perennial snowfields degraded significantly (70–90% of the area had melted) due to the temperature rise. Some ones transformed into the category of perennial snowfields.  Large corrie glaciers located on the leeward slopes of wide watersheds in the negative relief forms did only slight retreat. They mostly continue to exist because the amount of accumulated snow mass increased and, thus, compensated the ablation. The largest decrease in the area of glaciers took place in 2002–2004. Since 2005, large glaciers stopped to degrade and were in relative equilibrium with climate. This article presents estimation of dynamics of the Kuznetsky Alatau glaciers since their cataloging made in the 1980-s, and it contains the detailed information about fluctuation of areas of glaciers Karatash № 56, Cherno-Iyussky № 83, and Tsentralny № 87 in 1975–2015 received from data obtained in field measurements and remote sensing methods. The area increase of some individual glaciers since 2005 is shown. An effort to compare dynamics of main climatic factors having impact on the glaciations with the dynamics of the glacier areas had been made.Статья посвящена анализу изменений климата и нивально-гляциальных систем гор Кузнецкого Алатау (Западная Сибирь) за последние 40 лет. Установлен факт увеличения площади отдельных крупных ледников района. Колебания ледников рассматриваются на фоне трендов изменения средних летних температур воздуха и годового количества осадков по метеостанции Ненастная – единственной высокогорной станции в горах Кузнецкого Алатау

Complications after anesthesia in gynecological practice

The article presents a comparative analysis of complications in the early postoperative period, after the use of various types of intravenous anesthesia. The study was conducted by interviewing 25 patients of gynecological hospital.В статье представлен сравнительный анализ осложнений в раннем послеоперационном периоде, после применения различных видов внутривенной анестезии. Исследование проводилось путем опроса 25 пациенток гинекологического стационара

IN SITU VASCULAR TISSUE REMODELING USING BIODEGRADABLE TUBULAR SCAFFOLDS WITH INCORPORATED GROWTH FACTORS AND CHEMOATTRACTANT MOLECULES

Background Currently, the search for the bioactive molecules capable of promoting formation of the vascular tissue is still ongoing. We have previously demonstrated that incorporation of the growth factors and chemoattractant molecules into the biodegradable tubular scaffolds can increase their primary patency upon the implantation into rat abdominal aorta. However, further studies are required to investigate tissue remodeling using functionalized vascular grafts with the same diameter as a replaced native vessel. Aim To investigate the specific aspects of de novo vascular tissue formation and calcification employing rat abdominal aorta interposition model and vascular grafts with 1.5 mm diameter with incorporated vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and stromal cell-derived factor (SDF)-1α. Methods Tubular grafts with a diameter of 1.5 mm were blended of poly(3-hydroxybutyrateco-3-hydroxyvalerate) and poly(ε-caprolactone) (PHBV/PCL). Grafts without growth factors were fabricated using standard electrospinning technique whilst grafts with incorporated growth factors were prepared utilizing emulsion electrospinning. VEGF was incorporated into the inner third, whereas bFGF and SDF-1α were incorporated into the outer two-thirds of the graft. Grafts were implanted into the abdominal aortas of Wistar rats for 1, 3, 6, and 12 months following scanning electron microscopy along with histological and immunofluorescent examination. Results Primary patency of the grafts with VEGF, bFGF, and SDF-1α reached 93% indicative of structural integrity of the vascular tissue. Neither signs of inflammation nor severe calcification was detected. Conclusion As in 2 mm diameter vascular grafts, incorporation of bioactive factors into 1.5 mm diameter grafts increased their long-term primary patency and improved vascular tissue formation in comparison with non-modified grafts.  Background Currently, the search for the bioactive molecules capable of promoting formation of the vascular tissue is still ongoing. We have previously demonstrated that incorporation of the growth factors and chemoattractant molecules into the biodegradable tubular scaffolds can increase their primary patency upon the implantation into rat abdominal aorta. However, further studies are required to investigate tissue remodeling using functionalized vascular grafts with the same diameter as a replaced native vessel. Aim To investigate the specific aspects of de novo vascular tissue formation and calcification employing rat abdominal aorta interposition model and vascular grafts with 1.5 mm diameter with incorporated vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and stromal cell-derived factor (SDF)-1α. Methods Tubular grafts with a diameter of 1.5 mm were blended of poly(3-hydroxybutyrateco-3-hydroxyvalerate) and poly(ε-caprolactone) (PHBV/PCL). Grafts without growth factors were fabricated using standard electrospinning technique whilst grafts with incorporated growth factors were prepared utilizing emulsion electrospinning. VEGF was incorporated into the inner third, whereas bFGF and SDF-1α were incorporated into the outer two-thirds of the graft. Grafts were implanted into the abdominal aortas of Wistar rats for 1, 3, 6, and 12 months following scanning electron microscopy along with histological and immunofluorescent examination. Results Primary patency of the grafts with VEGF, bFGF, and SDF-1α reached 93% indicative of structural integrity of the vascular tissue. Neither signs of inflammation nor severe calcification was detected. Conclusion As in 2 mm diameter vascular grafts, incorporation of bioactive factors into 1.5 mm diameter grafts increased their long-term primary patency and improved vascular tissue formation in comparison with non-modified grafts

Psychological Profile of Successful Criminal Police Officer

Psychological Profile of Successful Criminal Police Officer / Volodymyr Ostapovich, Vadym Barko, Ivan Okhrimenko, Olena Yevdokimova, Yana Ponomarenko, Kostiantyn Prontenko, Olena Antonova, Ninel Sydorchuk, Oleh Sokolovskyi, Ihor Bloshchynskyi // International Journal of Applied Exercise Physiology. – 2020. – Vol. 9 (3). – P. 120-133.Ostapovich, V., Barko, V., Okhrimenko, I., Yevdokimova, O., Ponomarenko, Y., Prontenko, K., Antonova, O., Sydorchuk, N., Sokolovskyi, O., & Bloshchynskyi, I. (2020). Psychological Profile of Successful Criminal Police Officer. International Journal of Applied Exercise Physiology, 9(3), 120-133. Retrieved from http://www.ijaep.com/index.php/IJAE/article/view/755.Розглянуто психологічні особливості професійної діяльності працівників підрозділів кримінальної поліції України, основні вимоги професії до психологічних характеристик, знань і умінь працівників кримінальної міліції, мотиви професійного вибору, психологічні показання та протипоказання до професійної діяльності. Наголошено, що працівники кримінальної поліції виконують свої обов’язки в складних, а часом і в особливих та екстремальних умовах, тому для ефективного відбору та підготовки кадрів необхідно знати професійно важливі якості працівників кримінальної поліції.The article deals with the psychological peculiarities of professional activity of employees of criminal police units of Ukraine, the basic requirements of the profession for psychological characteristics, knowledge and skills of criminal police officers, motives for professional choice, psychological indications and contraindications to professional activity in position. The relevance of the study is due to the fact that the criminal police officers perform their duties in difficult and sometimes in special and extreme conditions, therefore, for the effective selection and training of personnel, it is necessary to know the professionally important qualities (PIQ) of criminal police officers. In order to study the professionally important qualities of police officers a research was conducted during 2018. 350 criminal police officers (298 male policemen, 52 female policemen) from 20 regions of Ukraine took part in it (aged 25 to 42); the special ranks of the respondents are from lieutenant to lieutenant colonel of the police; all police officers were characterized by experts as "successful". Research methods: observations, surveys, interviews with experts, psychological testing, methods of mathematical statistics. The analysis of the average psychological profile of the "successful" criminal police officers’ personality allows characterizing the employees as persons with asthenic type of response, high activity and high level of aspiration, striking emotional reactions, which, at the same time, are sufficiently controlled. Specialists have strength and lability nervous system, a leading style of behavior, the ability to take risks with strong stress resistance. Regarding the motivational sphere, the first place in importance belongs to the motives and values related to the personal self-realization. Тhe criminal police officers’ professional activities are characterized by complexity and emotional tension, occurring in difficult conditions; in order to be successful in performing his/her duties, the police officer must be psychologically prepared for the activity, possess a range of professionally important qualities, knowledge and skills.Рассмотрены психологические особенности профессиональной деятельности работников подразделений криминальной полиции Украины, основные требования профессии к психологическим характеристикам, знаниям и умениям работников криминальной милиции, мотивы профессионального выбора, психологические показания и противопоказания к профессиональной деятельности. Отмечено, что работники криминальной полиции выполняют свои обязанности в сложных, а иногда и в особых и экстремальных условиях, поэтому для эффективного отбора и подготовки кадров необходимо знать профессионально важные качества работников криминальной полиции

ОЦЕНКА IN VITRO АКТИВНОСТИ РОСТОВЫХ ФАКТОРОВ И ХЕМОАТТРАКТАНТНЫХ МОЛЕКУЛ, ИНКОРПОРИРОВАННЫХ В ПОЛИМЕРНЫЕ МАТРИКСЫ НА ОСНОВЕ ПОЛИГИДРОКСИБУТИРАТА/ ВАЛЕРАТА И ПОЛИКАПРОЛАКТОНА

Background We fabricated biodegradable, bioactive scaffolds to guide the differentiation of endothelial progenitor cells. Aim To study in vitro activity of the bioactive factors incorporated into the poly (3-hydroxubutyrate-co-3-hydroxyvalerate)/poly(ε-caprolactone) (PHBV/PCL) scaffolds. Methods Nonwoven scaffolds were blended of PHBV and PCL utilizing either separate or combined incorporation of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and stromal cell-derived factor-1α (SDF-1α) by emulsion electrospinning. We further studied adhesion, viability, and proliferation of EA.hy 926 endothelial cells cultured on these scaffolds and evaluated vasculogenesis, cell index, and secretory profile in response to the addition of abovementioned bioactive factors. Results We showed that VEGF, bFGF, and SDF-1α retain their bioactivity upon the incorporation into the PHBV/PCL scaffolds. Scaffolds with all three bioactive factors incorporated demonstrated superior performance in comparison with those containing any of these factors alone. Diffusion of the bioactive factors into the culture medium stimulated the secretion of interleukin-10, and VE-cadherin by endothelial cells that indicated anti-inflammatory response and tight intercellular junctions. We also detected the low level of secreted VEGF-A from the scaffolds with VEGF suggestive of its physiological regulation. Conclusion Bioactive factors retain their bioactivity upon the incorporation into the PHBV/ PCL scaffolds. Combination of VEGF, bFGF, and SDF-1a improves cellular response compared to the incorporation of any of these factors alone.Актуальность Для создания функционально активных биодеградируемых матриксов, способных задавать вектор клеточному отклику в организме, были изготовлены нетканые матриксы с ростовыми факторами и хемоаттрактантными молекулами. Цель Изучить в эксперименте с эндотелиальными клетками in vitro активность ростовых факторов и хемоаттрактантных молекул, инкорпорированных в состав полимерных матриксов на основе полигидроксибутирата/валерата и поликапролактона. Материалы и методы Нетканые матриксы из полигидроксибутирата/валерата и поликапролактона (PHBV/PCL) с изолированным или сочетанным введением в структуру сосудистого эндотелиального фактора роста VEGF, основного фактора роста фибробластов bFGF и хемоаттрактантной молекулы SDF-1a были изготовлены методом двухфазного электроспиннинга. С использованием культуры эндотелиальных клеток линии EA.hy 926 изучены адгезия, жизнеспособность и пролиферация клеток, культивируемых на поверхности матриксов, а также васкулогенез, секреторная активность и клеточный индекс клеток в ответ на диффузию в среду культивирования инкорпорированных в матриксы веществ. Результаты При анализе комплекса показателей доказана сохранность активности VEGF, bFGF и SDF-1a, инкорпорированных в состав матриксов PHBV/PCL, а также преимущество матриксов, содержащих комплекс ростовых факторов и хемоаттрактантных молекул (GFmix), в плане сбалансированности своего воздействия на адгезию, пролиферацию, жизнеспособность эндотелиальных клеток и активацию васкулогенеза. Диффузия из матриксов комплекса GFmix в культуральную среду стимулировала секрецию эндотелиоцитамить IL-10, и VE-кадгерина, что демонстрирует противовоспалительную активность и хороший клеточный контакт. Низкий уровень секретируемого клетками EA.hy 926 VEGF-A в лунках с матриксами, содержащими VEGF и GFmix, мог отражать феномен обратной связи, когда синтез вещества тормозится на фоне его достаточного присутствия в окружающей среде. Заключение Ростовые факторы и хемоаттрактантные молекулы, вводимые в состав нетканых полимерных матриксов методом электроспиннинга, сохраняют свою биологическую активность. Сочетание VEGF, bFGF и SDF-1a в составе одного матрикса синхронизирует эффекты клеточного отклика в отличие от изолированного введения данных веществ в состав матриксов.

Supernova neutrino burst detection with the Deep Underground Neutrino Experiment

The Deep Underground Neutrino Experiment (DUNE), a 40-kton underground liquid argon time projection chamber experiment, will be sensitive to the electron-neutrino flavor component of the burst of neutrinos expected from the next Galactic core-collapse supernova. Such an observation will bring unique insight into the astrophysics of core collapse as well as into the properties of neutrinos. The general capabilities of DUNE for neutrino detection in the relevant few- to few-tens-of-MeV neutrino energy range will be described. As an example, DUNE's ability to constrain the νe spectral parameters of the neutrino burst will be considered

Experiment Simulation Configurations Approximating DUNE TDR

The Deep Underground Neutrino Experiment (DUNE) is a next-generation long-baseline neutrino oscillation experiment consisting of a high-power, broadband neutrino beam, a highly capable near detector located on site at Fermilab, in Batavia, Illinois, and a massive liquid argon time projection chamber (LArTPC) far detector located at the 4850L of Sanford Underground Research Facility in Lead, South Dakota. The long-baseline physics sensitivity calculations presented in the DUNE Physics TDR, and in a related physics paper, rely upon simulation of the neutrino beam line, simulation of neutrino interactions in the near and far detectors, fully automated event reconstruction and neutrino classification, and detailed implementation of systematic uncertainties. The purpose of this posting is to provide a simplified summary of the simulations that went into this analysis to the community, in order to facilitate phenomenological studies of long-baseline oscillation at DUNE. Simulated neutrino flux files and a GLoBES configuration describing the far detector reconstruction and selection performance are included as ancillary files to this posting. A simple analysis using these configurations in GLoBES produces sensitivity that is similar, but not identical, to the official DUNE sensitivity. DUNE welcomes those interested in performing phenomenological work as members of the collaboration, but also recognizes the benefit of making these configurations readily available to the wider community

Deep Underground Neutrino Experiment (DUNE), Far Detector Technical Design Report, Volume II: DUNE Physics

The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay -- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. DUNE is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. Volume II of this TDR, DUNE Physics, describes the array of identified scientific opportunities and key goals. Crucially, we also report our best current understanding of the capability of DUNE to realize these goals, along with the detailed arguments and investigations on which this understanding is based. This TDR volume documents the scientific basis underlying the conception and design of the LBNF/DUNE experimental configurations. As a result, the description of DUNE's experimental capabilities constitutes the bulk of the document. Key linkages between requirements for successful execution of the physics program and primary specifications of the experimental configurations are drawn and summarized. This document also serves a wider purpose as a statement on the scientific potential of DUNE as a central component within a global program of frontier theoretical and experimental particle physics research. Thus, the presentation also aims to serve as a resource for the particle physics community at large