Using MathML to Represent Units of Measurement for Improved Ontology Alignment

Ontologies provide a formal description of concepts and their relationships in a knowledge domain. The goal of ontology alignment is to identify semantically matching concepts and relationships across independently developed ontologies that purport to describe the same knowledge. In order to handle the widest possible class of ontologies, many alignment algorithms rely on terminological and structural meth- ods, but the often fuzzy nature of concepts complicates the matching process. However, one area that should provide clear matching solutions due to its mathematical nature, is units of measurement. Several on- tologies for units of measurement are available, but there has been no attempt to align them, notwithstanding the obvious importance for tech- nical interoperability. We propose a general strategy to map these (and similar) ontologies by introducing MathML to accurately capture the semantic description of concepts specified therein. We provide mapping results for three ontologies, and show that our approach improves on lexical comparisons.Comment: Conferences on Intelligent Computer Mathematics (CICM 2013), Bath, Englan

Detecting and Correcting Conservativity Principle Violations in Ontology-to-Ontology Mappings

In order to enable interoperability between ontology-based systems, ontology matching techniques have been proposed. However, when the generated mappings suffer from logical flaws, their usefulness may be diminished. In this paper we present an approximate method to detect and correct violations to the so-called conservativity principle where novel subsumption entailments between named concepts in one of the input ontologies are considered as unwanted. We show that this is indeed the case in our application domain based on the EU Optique project. Additionally, our extensive evaluation conducted with both the Optique use case and the data sets from the Ontology Alignment Evaluation Initiative (OAEI) suggests that our method is both useful and feasible in practice.Copyright 2014 Springer International Publishing Switzerland. The final publication is available at http://link.springer.com/chapter/10.1007%2F978-3-319-11915-1_

Dealing with matching variability of semantic web data using contexts

Goal of this paper is to propose a reference modeling framework to explicitly identify and formalize the different levels of variability that can arise along all the involved dimensions of a matching execution. The proposed framework is based on the notion of knowledge chunk, context, and mapping to abstract the variability levels and related operations along the source-dataset, the matching-dataset, and the mapping-set dimensions, respectively. An application of the proposed framework with instantiation in the HMatch 2.0 systems is illustrated

Can hypoxia influence on the performance of the hMSCs? scoping review

This study aimed to systematically review the literature as fort influence of the hypoxia on human mesenchymal stem cells (hMSCs). The review is reported in accordance with the PRISMA Statement. Two reviewers conducted a literature search of three databases: PubMed (Medline), Web of Science and Scopus, until May 2016. All studies that analyzed condition of hypoxia in the design experiment were included. Data regarding author, year of publication, cell type, tissue site type of study, oxygen concentration used, evaluation methods, induction time courseand main findings were tabulated to assess the following outcomes of interest: changes in (paracrine or autocrine effect) cell behavior(cell differentiation, viability/proliferation, migration). After screening a total of 1537 potentially relevant documents, 139 studies were subjected to qualitative analysis. In 69% of the studies, cellular modification was performed. Additionally, the most studied modifications were cell migration, proliferation/viability, differentiation and expression of VEGF, HIF-1a. In conclusion, there is evidence in the literature that the conditioning in hypoxia improves the metabolism and expression of hMSCs but this result cannot be extended to all type. In conclusion, most stem cells need of the hypoxia as the natural environment in their niches which will allowusing the at most and empower the performance in regenerative therapies.Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPqEste estudo teve como objetivo revisar sistematicamente a literatura como forte influência da hipóxia em células-tronco mesenquimais humanas (hMSCs). A revisão é relatada de acordo com a Declaração PRISMA. Dois revisores realizaram uma pesquisa bibliográfica de três bancos de dados: PubMed (Medline), Web of Science e Scopus. Todos os estudos que analisaram a condição de hipóxia no desenho do experimento foram incluídos. Os dados relativos ao autor, ao ano de publicação, ao tipo de célula, ao tipo de estudo do local do tecido, à concentração de oxigênio utilizada, aos métodos de avaliação, ao curso de indução e aos achados principais foram tabulados para avaliar os seguintes resultados de interesse: mudanças no comportamento celular (paracrino ou autocrino), diferenciação celular, viabilidade / proliferação, migração. Após a triagem de um total de 1537 documentos potencialmente relevantes, 139 estudos foram submetidos a análise qualitativa. Em 69% dos estudos, a modificação celular foi realizada. Adicionalmente, as modificações mais estudadas foram migração celular, proliferação / viabilidade, diferenciação e expressão de VEGF, HIF-1a. Em conclusão, há evidências na literatura de que o condicionamento na hipóxia melhora o metabolismo e a expressão de hMSCs, mas esse resultado não pode ser estendido a todos os tipos. Em conclusão, a maioria das células estaminais precisa da hipóxia como o ambiente natural em seus nichos, o que permitirá usa-la no seu máximo potencial e capacitar o desempenho em terapias regenerativas