345 research outputs found
Recent advances in femtosecond laser writing inside transparent materials
Modification of transparent materials with ultrafast lasers has attracted considerable interest due to a wide range of applications including laser surgery, integrated optics, optical data storage, 3D microand nano-structuring [1].T Three different types of material modifications can be induced with ultrafast laser irradiation in the bulk of a transparent material, silica glass in particular: an isotropic refractive index change (type 1); a form birefringence associated with self-assembled nanogratings and negative refractive index change (type 2) [2,3]; and a void (type 3). In fused silica the transition from type 1 to type 2 and finally to type 3 modification is observed with an increase of fluence. Recently, a remarkable phenomenon in ultrafast laser processing of transparent materials has been reported manifesting itself as a change in material modification by reversing the writing direction [4]. The phenomenon has been interpreted in terms of anisotropic plasma heating by a tilted front of the ultrashort laser pulse. Moreover a change in structural modification has been demonstrated in glass by controlling the direction of pulse front tilt, achieving a calligraphic style of laser writing which is similar in appearance to that inked with the bygone quill pen [5]. It has also been a common belief that in a homogeneous medium, the photosensitivity and corresponding light-induced material modifications do not change on the reversal of light propagation direction. More recently it have observed that in a non-centrosymmetric medium, modification of the material can be different when light propagates in opposite directions (KaYaSo effect) [6]. Moreover a new phenomenon of ultrafast light blade, representing itself the first evidence of anisotropic sensitivity of isotropic medium to femtosecond laser radiation has been recently discovered [7]. We attribute these new phenomena to the anisotropy of the light-matter interaction caused by space-time couplings in ultrashort light pulses. We anticipate that the observed phenomena will open new opportunities in laser material processing, laser surgery, optical manipulation and data storage
Molecular cytogenetic aberrations in patients with multiple myeloma studied by interphase fluorescence in situ hybridization
Background: Multiple myeloma (MM) is an incurable hematological disorder characterized by the accumulation of malignant plasma cells within the bone marrow (BM). The clinical heterogeneity of MM is dictated by the cytogenetic aberrations present in the clonal plasma cells (PCs). Cytogenetic studies in MM are hampered by the hypoproliferative nature of plasma cells in MM. Therefore, fluorescence in situ hybridization (FISH) analysis combined with magnetic-activated cell sorting (MACS) is an attractive alternative for evaluation of numerical and structural chromosomal changes in MM. Methods: Interphase FISH studies with three different specific probes for the regions containing 13q14.3 (D13S319), 14q32 (IGHC/IGHV) and 1q12(CEP1 ) were performed in 48 MM patients. Interphase FISH studies with LSI IGH/CCND1, LSI IGH/FGFR3, and LSI IGH/MAF probes were used to detect t(11;14)(q13;q32), t(4;14)(p16;q32), and t(14;16)(q32;q23) in patients with 14q32 rearrangement. Results: Molecular cytogenetic aberrations were found in 40 (83.3%) of the 48 MM patients. 13 patients (27.1%) simultaneously had 13q deletion/monosomy 13 [del(13q14)], illegitimate IGH rearrangement and chromosome 1 abnormality. Del(13q14) was detected in 21 cases (43.7%), and illegitimate IGH rearrangements in 29 (60.4%) including 6 with t(11;14) and 5 with t(4;14). None of 9 patients with illegitimate IGH rearrangements and without t(11;14) or t(4;14) we detected had t(14;16) (q32;q23). 24 of the 48 MM patients (50%) had chromosome 1 abnormalities. Among 21 patients with del(13q14), 15 patients had Amp1q12;16 had IgH rearrangements. Whereas, among 27 cases without del(13q14), 8 had Amp1q12; 13 had IgH rearrangements. There was a strong association between del(13q14) and Amp1q12(c2 = 8.26, Ρ < 0.01), and between del(13q14) and IgH rearrangement(c2 = 3.88, p < 0.05). Conclusion: 13q deletion/monosomy 13, IGH rearrangement and chromosome 1 abnormality are frequent in MM. They are not randomly distributed, but strongly interconnected. Interphase FISH technique combined with MACS using CD138-specific antibody is a highly sensitive technique at detecting molecular cytogenetic aberrations in MM.ΠΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠ΅: ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Π΅Π½Π½Π°Ρ ΠΌΠΈΠ΅Π»ΠΎΠΌΠ° (MM) β Π½Π΅ΠΈΠ·Π»Π΅ΡΠΈΠΌΠΎΠ΅ Π³Π΅ΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΈΡΡΡΡΠ΅Π΅ΡΡ
Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΠ΅ΠΌ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΏΠ»Π°Π·ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΊΠ»Π΅ΡΠΎΠΊ Π² ΠΊΠΎΡΡΠ½ΠΎΠΌ ΠΌΠΎΠ·Π³Π΅ (ΠM). ΠΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠ°Ρ Π³Π΅ΡΠ΅ΡΠΎΠ³Π΅Π½Π½ΠΎΡΡΡ MM ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅ΡΡΡ
ΡΠΈΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Π°Π±Π΅ΡΡΠ°ΡΠΈΡΠΌΠΈ, ΠΏΡΠΈΡΡΡΡΡΠ²ΡΡΡΠΈΠΌΠΈ Π² ΠΊΠ»ΠΎΠ½Π΅ ΠΏΠ»Π°Π·ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΊΠ»Π΅ΡΠΎΠΊ (ΠΠ). Π¦ΠΈΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ
MM ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½Ρ Π³ΠΈΠΏΠΎΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΠΌΠΈ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΡΠΌΠΈ ΠΠ. Π ΡΠ²ΡΠ·ΠΈ Ρ ΡΡΠΈΠΌ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠ½Π°Ρ Π³ΠΈΠ±ΡΠΈΠ΄ΠΈΠ·Π°ΡΠΈΡ in situ (FISH)
Π² ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΈΠΈ Ρ ΡΠΎΡΡΠΈΡΠΎΠ²ΠΊΠΎΠΉ ΠΊΠ»Π΅ΡΠΎΠΊ, Π°ΠΊΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΌΠ°Π³Π½ΠΈΡΠ½ΡΠΌΠΈ ΠΏΠΎΠ»ΡΠΌΠΈ (MACS) ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅ΡΡΡ Π΄ΠΎΡΡΠΎΠΉΠ½ΠΎΠΉ Π°Π»ΡΡΠ΅ΡΠ½Π°ΡΠΈΠ²ΠΎΠΉ
ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΠΎΡΠ΅ΡΠ½ΡΡ
ΠΈ ΡΡΡΡΠΊΡΡΡΠ½ΡΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌ ΠΏΡΠΈ MM. ΠΠ΅ΡΠΎΠ΄Ρ: ΠΈΠ½ΡΠ΅ΡΡΠ°Π·Π½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ
FISH Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΡΠ΅Ρ
ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π·ΠΎΠ½Π΄ΠΎΠ² Π΄Π»Ρ ΡΡΠ°ΡΡΠΊΠΎΠ², ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
13q14.3 (D13S319), 14q32
(IGHC/IGHV) ΠΈ 1q12(CEP1), ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Ρ 48 Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ MM. ΠΠ½ΡΠ΅ΡΡΠ°Π·Π½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ FISH Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ
Π·ΠΎΠ½Π΄ΠΎΠ² LSI IGH/CCND1, LSI IGH/FGFR3 ΠΈ LSI IGH/MAF ΠΏΡΠΈΠΌΠ΅Π½ΡΠ»ΠΈ Π΄Π»Ρ Π΄Π΅ΡΠ΅ΠΊΡΠΈΠΈ t(11;14)(q13;q32), t(4;14)(p16;q32), ΠΈ
t(14;16)(q32;q23) Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΏΠ΅ΡΠ΅ΡΡΡΠΎΠΉΠΊΠΎΠΉ 14q32. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ: ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠ΅ ΡΠΈΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π°Π±Π΅ΡΡΠ°ΡΠΈΠΈ Π²ΡΡΠ²Π»ΡΠ»ΠΈ Ρ
40 (83,3%) ΠΈΠ· 48 Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ MM. Π£ 13 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² (27,1%) ΠΎΠ΄Π½ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ 13q Π΄Π΅Π»Π΅ΡΠΈΡ/ΠΌΠΎΠ½ΠΎΡΠΎΠΌΠΈΡ 13 [del(13q14)],
Π°Π½ΠΎΠΌΠ°Π»ΡΠ½Π°Ρ ΠΏΠ΅ΡΠ΅ΡΡΡΠΎΠΉΠΊΠ° IGH ΠΈ Π°Π½ΠΎΠΌΠ°Π»ΠΈΡ Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΡ 1. Del(13q14) Π΄Π΅ΡΠ΅ΠΊΡΠΈΡΠΎΠ²Π°Π»ΠΈ Π² 21 ΡΠ»ΡΡΠ°Π΅ (43,7%), Π° Π°Π½ΠΎΠΌΠ°Π»ΡΠ½ΡΠ΅
ΠΏΠ΅ΡΠ΅ΡΡΡΠΎΠΉΠΊΠΈ IGH β Π² 29 (60,4%), Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ Ρ 6 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ t(11;14) ΠΈ 5 Ρ t(4;14). ΠΠΈ Ρ ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΈΠ· 9 Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ Π°Π½ΠΎΠΌΠ°Π»ΡΠ½ΡΠΌΠΈ
ΠΏΠ΅ΡΠ΅ΡΡΡΠΎΠΉΠΊΠ°ΠΌΠΈ IGH ΠΈ Π±Π΅Π· t(11;14) ΠΈΠ»ΠΈ t(4;14) Π½Π΅ Π²ΡΡΠ²Π»ΡΠ»ΠΈ ΡΡΠ°Π½ΡΠ»ΠΎΠΊΠ°ΡΠΈΡ t(14;16) (q32;q23). Π£ 24 ΠΈΠ· 48 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ MM
(50%) ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ Π°Π½ΠΎΠΌΠ°Π»ΠΈΠΈ Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΡ 1. Π Π³ΡΡΠΏΠΏΠ΅ ΠΈΠ· 21 Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ del(13q14) Π² 15 ΡΠ»ΡΡΠ°ΡΡ
ΠΈΠΌΠ΅Π»ΠΈΡΡ ΠΏΠ΅ΡΠ΅ΡΡΡΠΎΠΉΠΊΠΈ IgH
Amp1q12;16. Π ΡΠΎ ΠΆΠ΅ Π²ΡΠ΅ΠΌΡ ΠΈΠ· 27 ΡΠ»ΡΡΠ°Π΅Π² Π±Π΅Π· del(13q14) Ρ 8 ΡΠΎΠ΄Π΅ΡΠΆΠ°Π»ΠΈΡΡ Amp1q12; Π² 13 ΡΠ»ΡΡΠ°ΡΡ
ΠΎΡΠΌΠ΅ΡΠ°Π»ΠΈ ΠΏΠ΅ΡΠ΅ΡΡΡΠΎΠΉΠΊΠΈ
IgH. ΠΡΡΠ²Π»Π΅Π½Π° Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Ρ ΠΌΠ΅ΠΆΠ΄Ρ del(13q14) ΠΈ Amp1q12(Ο2
= 8,26, p < 0,01) ΠΈ ΠΌΠ΅ΠΆΠ΄Ρ del(13q14) ΠΈ ΠΏΠ΅ΡΠ΅ΡΡΡΠΎΠΉΠΊΠ°ΠΌΠΈ IgH
(Ο2 = 3,88, p < 0,05). ΠΡΠ²ΠΎΠ΄Ρ: 13q Π΄Π΅Π»Π΅ΡΠΈΡ/ΠΌΠΎΠ½ΠΎΡΠΎΠΌΠΈΡ 13, ΠΏΠ΅ΡΠ΅ΡΡΡΠΎΠΉΠΊΡ IGH ΠΈ Π°Π½ΠΎΠΌΠ°Π»ΠΈΡ Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΡ 1 ΡΠ°ΡΡΠΎ ΠΎΡΠΌΠ΅ΡΠ°ΡΡ
ΠΏΡΠΈ MM, ΠΏΡΠΈΡΠ΅ΠΌ ΠΈΡ
ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π½Π΅ ΡΠ»ΡΡΠ°ΠΉΠ½ΠΎ ΠΈ ΡΠ΅ΡΠ½ΠΎ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Π°Π½ΠΎ. ΠΠ½ΡΠ΅ΡΡΠ°Π·Π½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· FISH Π² ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΈΠΈ Ρ
MACS Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ CD138-ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΡΡ
Π°Π½ΡΠΈΡΠ΅Π» ΡΠ²Π»ΡΠ΅ΡΡΡ Π²ΡΡΠΎΠΊΠΎΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π΄Π΅ΡΠ΅ΠΊΡΠΈΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ
ΡΠΈΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π°Π±Π΅ΡΡΠ°ΡΠΈΠΉ ΠΏΡΠΈ MM
Effects of polysaccharide from Ophiopogon japonicus on immune response to Newcastle disease vaccine in chicken
Measurements of the observed cross sections for exclusive light hadrons containing at , 3.650 and 3.6648 GeV
By analyzing the data sets of 17.3, 6.5 and 1.0 pb taken,
respectively, at , 3.650 and 3.6648 GeV with the BES-II
detector at the BEPC collider, we measure the observed cross sections for
, , ,
and at the three energy
points. Based on these cross sections we set the upper limits on the observed
cross sections and the branching fractions for decay into these
final states at 90% C.L..Comment: 7 pages, 2 figure
Partial wave analysis of J/\psi \to \gamma \phi \phi
Using events collected in the BESII detector, the
radiative decay is
studied. The invariant mass distribution exhibits a near-threshold
enhancement that peaks around 2.24 GeV/.
A partial wave analysis shows that the structure is dominated by a
state () with a mass of
GeV/ and a width of GeV/. The
product branching fraction is: .Comment: 11 pages, 4 figures. corrected proof for journa
Direct Measurements of Absolute Branching Fractions for D0 and D+ Inclusive Semimuonic Decays
By analyzing about 33 data sample collected at and around 3.773
GeV with the BES-II detector at the BEPC collider, we directly measure the
branching fractions for the neutral and charged inclusive semimuonic decays
to be and , and determine the ratio of the two branching
fractions to be
A study of charged kappa in
Based on events collected by BESII, the decay
is studied. In the invariant mass
spectrum recoiling against the charged , the charged
particle is found as a low mass enhancement. If a Breit-Wigner function of
constant width is used to parameterize the kappa, its pole locates at MeV/. Also in this channel,
the decay is observed for the first time.
Its branching ratio is .Comment: 14 pages, 4 figure
Critical behavior of the two-dimensional N-component Landau-Ginzburg Hamiltonian with cubic anisotropy
We study the two-dimensional N-component Landau-Ginzburg Hamiltonian with
cubic anisotropy. We compute and analyze the fixed-dimension perturbative
expansion of the renormalization-group functions to four loops. The relations
of these models with N-color Ashkin-Teller models, discrete cubic models,
planar model with fourth order anisotropy, and structural phase transition in
adsorbed monolayers are discussed. Our results for N=2 (XY model with cubic
anisotropy) are compatible with the existence of a line of fixed points joining
the Ising and the O(2) fixed points. Along this line the exponent has
the constant value 1/4, while the exponent runs in a continuous and
monotonic way from 1 to (from Ising to O(2)). For N\geq 3 we find a
cubic fixed point in the region , which is marginally stable or
unstable according to the sign of the perturbation. For the physical relevant
case of N=3 we find the exponents and at the cubic
transition.Comment: 14 pages, 9 figure
Measurements of the observed cross sections for exclusive light hadron production in e^+e^- annihilation at \sqrt{s}= 3.773 and 3.650 GeV
By analyzing the data sets of 17.3 pb taken at GeV
and 6.5 pb taken at GeV with the BESII detector at the
BEPC collider, we have measured the observed cross sections for 12 exclusive
light hadron final states produced in annihilation at the two energy
points. We have also set the upper limits on the observed cross sections and
the branching fractions for decay to these final states at 90%
C.L.Comment: 8 pages, 5 figur
- β¦