Growth to early adulthood following extremely preterm birth: the EPICure study.

OBJECTIVE: To investigate growth trajectories from age 2.5 to 19 years in individuals born before 26 weeks of gestation (extremely preterm; EP) compared with term-born controls. METHODS: Multilevel modelling of growth data from the EPICure study, a prospective 1995 birth cohort of 315 EP participants born in the UK and Ireland and 160 term-born controls recruited at school age. Height, weight, head circumference and body mass index (BMI) z-scores were derived from UK standards at ages 2.5, 6, 11 and 19 years. RESULTS: 129 (42%) EP children were assessed at 19 years. EP individuals were on average 4.0 cm shorter and 6.8 kg lighter with a 1.5 cm smaller head circumference relative to controls at 19 years. Relative to controls, EP participants grew faster in weight by 0.06 SD per year (95% CI 0.05 to 0.07), in head circumference by 0.04 SD (95% CI 0.03 to 0.05), but with no catch-up in height. For the EP group, because of weight catch-up between 6 and 19 years, BMI was significantly elevated at 19 years to +0.32 SD; 23.4% had BMI >25 kg/m2 and 6.3% >30 kg/m2 but these proportions were similar to those in control subjects. EP and control participants showed similar pubertal development in early adolescence, which was not associated with height at 19 years in either study group. Growth through childhood was related to birth characteristics and to neonatal feeding practices. CONCLUSIONS: EP participants remained shorter and lighter and had smaller head circumferences than reference data or controls in adulthood but had elevated BMI

A Review on Topology Optimization Strategies for Additively Manufactured Continuous Fiber-Reinforced Composite Structures

Topology Optimization (TO) recently gained importance due to the development of Ad- ditive Manufacturing (AM) processes that produce components with good mechanical properties. Among all additive manufacturing technologies, continuous fiber fused filament fabrication (CF4) can fabricate high-performance composites compared to those manufactured with conventional technolo- gies. In addition, AM provides the excellent advantage of a high degree of reconfigurability, which is in high demand to support the immediate short-term manufacturing chain in medical, transportation, and other industrial applications. CF4 enables the fabrication of continuous fiber-reinforced compos- ite (FRC) materials structures. Moreover, it allows us to integrate topology optimization strategies to design realizable CFRC structures for a given performance. Various TO strategies for attaining lightweight and high-performance designs have been proposed in the literature, exploiting AM’s design freedom. Therefore, this paper attempts to address works related to strategies employed to obtain optimal FRC structures. This paper intends to review and compare existing methods, analyze their similarities and dissimilarities, and discuss challenges and future trends in this field

Mechanism of Oxidative Stress in Neurodegeneration

Biological tissues require oxygen to meet their energetic demands. However, the consumption of oxygen also results in the generation of free radicals that may have damaging effects on cells. The brain is particularly vulnerable to the effects of reactive oxygen species due to its high demand for oxygen, and its abundance of highly peroxidisable substrates. Oxidative stress is caused by an imbalance in the redox state of the cell, either by overproduction of reactive oxygen species, or by dysfunction of the antioxidant systems. Oxidative stress has been detected in a range of neurodegenerative disease, and emerging evidence from in vitro and in vivo disease models suggests that oxidative stress may play a role in disease pathogenesis. However, the promise of antioxidants as novel therapies for neurodegenerative diseases has not been borne out in clinical studies. In this review, we critically assess the hypothesis that oxidative stress is a crucial player in common neurodegenerative disease and discuss the source of free radicals in such diseases. Furthermore, we examine the issues surrounding the failure to translate this hypothesis into an effective clinical treatment

[O III]λ5007\lambda 5007 and X-ray Properties of a Complete Sample of Hard X-ray Selected AGNs in the Local Universe

We study the correlation between the [O III]$\lambda 5007$ and X-ray luminosities of local Active Galactic Nuclei (AGNs), using a complete, hard X-ray ($>10$ keV) selected sample in the Swift/BAT 9-month catalog. From our optical spectroscopic observations at the South African Astronomical Observatory and the literature, a catalog of [O III]$\lambda 5007$ line flux for all 103 AGNs at Galactic latitudes of $|b|>15^\circ$ is complied. Significant correlations with intrinsic X-ray luminosity ($L_{\rm X}$) are found both for observed ($L_{\rm [O~III]}$) and extinction-corrected ($L_{\rm [O~III]}^{\rm cor}$) luminosities, separately for X-ray unabsorbed and absorbed AGNs. We obtain the regression form of $L_{\rm [O~III]}$ $\propto L_{\rm 2-10\; keV}^{1.18\pm0.07}$ and $L_{\rm [O~III]}^{\rm cor}$ $\propto L_{\rm 2-10\; keV}^{1.16\pm0.09}$ from the whole sample. The absorbed AGNs with low ($<$0.5\%) scattering fractions in soft X-rays show on average smaller $L_{\rm [O~III]}/L_{\rm X}$ and $L_{\rm [O~III]}^{\rm cor}/L_{\rm X}$ ratios than the other absorbed AGNs, while those in edge-on host galaxies do not. These results suggest that a significant fraction of this population are buried in tori with small opening angles. By using these $L_{\rm [O~III]}$ vs. $L_{\rm X}$ correlations, the X-ray luminosity function of local AGNs (including Compton thick AGNs) in a standard population synthesis model gives much better agreement with the [O III]$\lambda 5007$ luminosity function derived from the Sloan Digital Sky Survey than previously reported. This confirms that hard X-ray observations are a very powerful tool to find AGNs with high completeness.Comment: 14 pages including 11 figures and 3 tables, accepted for publication in ApJ. In this manuscript, the observed 14-195 keV luminosities in Table 1 have been corrected to be exactly the same as in the original Swift/BAT 9-month catalog. Accordingly, Figures 2(a) and 3(a) and a part of Tables 2 and 3 have been updated. The changes from the previous version are small and do not affect the tex

A rare presentation of cervical fibroid in pregnancy

Pregnancy in a fibroid uterus is not rare. However cervical fibroid is rare in pregnancy and has unique management challenges. We report a case of cervical fibroid in a Gravida2 Para1 patient that was found incidentally in a routine ultrasound in the second trimester. The fibroid grew in pregnancy till term, caused obstructed labour, a Cesarean section was required for the baby. Post surgery the fibroid prolapsed out of the introitus. Conservative  management was decided to prevent surgical complications, delayed consequences of surgery and to preserve future child bearing. The case shows that conservative management over surgery is sometimes the appropriate choice.Keywords: Cervical fibroid, conservative management, pregnanc

Pseudospectral Model Predictive Control under Partially Learned Dynamics

Trajectory optimization of a controlled dynamical system is an essential part of autonomy, however many trajectory optimization techniques are limited by the fidelity of the underlying parametric model. In the field of robotics, a lack of model knowledge can be overcome with machine learning techniques, utilizing measurements to build a dynamical model from the data. This paper aims to take the middle ground between these two approaches by introducing a semi-parametric representation of the underlying system dynamics. Our goal is to leverage the considerable information contained in a traditional physics based model and combine it with a data-driven, non-parametric regression technique known as a Gaussian Process. Integrating this semi-parametric model with model predictive pseudospectral control, we demonstrate this technique on both a cart pole and quadrotor simulation with unmodeled damping and parametric error. In order to manage parametric uncertainty, we introduce an algorithm that utilizes Sparse Spectrum Gaussian Processes (SSGP) for online learning after each rollout. We implement this online learning technique on a cart pole and quadrator, then demonstrate the use of online learning and obstacle avoidance for the dubin vehicle dynamics.Comment: Accepted but withdrawn from AIAA Scitech 201

Enhanced signal of astrophysical tau neutrinos propagating through Earth

Earth absorbs \nue and \numu of energies above about 100 TeV. As is well-known, although \nutau will also disappear through charged-current interactions, the \nutau flux will be regenerated by prompt tau decays. We show that this process also produces relatively large fluxes of secondary \nube and \nubmu, greatly enhancing the detectability of the initial \nutau. This is particularly important because at these energies \nutau is a significant fraction of the expected astrophysical neutrino flux, and only a tiny portion of the atmospheric neutrino flux.Comment: Four pages, two inline figure

Prospects for observations of high-energy cosmic tau neutrinos

We study prospects for the observations of high-energy cosmic tau neutrinos (E \geq 10^6 GeV) originating from proton acceleration in the cores of active galactic nuclei. We consider the possibility that vacuum flavor neutrino oscillations induce a tau to muon neutrino flux ratio greatly exceeding the rather small value expected from intrinsic production. The criterias and event rates for under water/ice light Cerenkov neutrino telescopes are given by considering the possible detection of downgoing high-energy cosmic tau neutrinos through characteristic double shower events.Comment: 10 pages, Revtex, 3 figures included with eps

Serendipitous discovery of an extended X-ray jet without a radio counterpart in a high-redshift quasar

A recent Chandra observation of the nearby galaxy cluster Abell 585 has led to the discovery of an extended X-ray jet associated with the high-redshift background quasar B3 0727+409, a luminous radio source at redshift z=2.5. This is one of only few examples of high-redshift X-ray jets known to date. It has a clear extension of about 12", corresponding to a projected length of ~100 kpc, with a possible hot spot located 35" from the quasar. The archival high resolution VLA maps surprisingly reveal no extended jet emission, except for one knot about 1.4" from the quasar. The high X-ray to radio luminosity ratio for this source appears consistent with the $\propto (1+z)^{4}$ amplification expected from the inverse Compton radiative model. This serendipitous discovery may signal the existence of an entire population of similar systems with bright X-ray and faint radio jets at high redshift, a selection bias which must be accounted for when drawing any conclusions about the redshift evolution of jet properties and indeed about the cosmological evolution of supermassive black holes and active galactic nuclei in general