Children with Behçet Disease-associated Thrombosis: A Single-Center Experience

Behçet disease (BD) is a systemic vasculitis that can be complicated with thrombosis, which is an important cause of mortality and morbidity. The course of BD is more severe, and the diagnosis is usually delayed. In children, thrombosis associated with BD is very rare. In this study, we aimed to evaluate the characteristics of children with BD complicated with thrombosis. Forty-six patients with BD who were followed-up at a pediatric rheumatology department between January 2012 and September 2019 were evaluated retrospectively. Thrombosis was detected in 10 patients (21.7%), and it was the first sign of BD in 7 patients. Four patients had cerebral sinus venous thrombosis, 4 patients had deep-vein thrombosis, 1 patient had renal vein thrombosis, 1 had pulmonary artery thrombosis, and 1 had intracardiac thrombosis. None of the patients had arterial thrombosis. All patients had received anticoagulant therapy with immunosuppressive treatment. Any complication due to anticoagulant therapy was not detected. One patient had recurrent thrombosis, and none of the patients died during follow-up. Vasculitic diseases such as BD may cause a predisposition to thrombosis, and thrombosis might be the first sign of BD. Therefore, in children presenting with unprovoked thrombosis, BD should also be investigated. © 2021 Lippincott Williams and Wilkins. All rights reserved

Recurrence of an atrial myxoma

PubMed ID: 1761341A 22-year-old man had an operation 14 years ago for removal of a left atrial myxoma. He was admitted to our hospital because of acute femoral arterial embolism. Echocardiographic examination revealed a mobile pedunculated echodense atrial mass attached to the atrial septum. At operation, the left atrium was found to be occupied with a gelatinous pale mass attached by a stalk to the atrial septum. The tumour was extirpated along with a part of atrial septum, which was assumed to be involved in the tumour. The atrial septal defect created was closed with patch. Histopathological examination of excised material revealed typical features of a myxoma. © 1991

Investigation of electrochemical behaviour of 3-allyl-4-hydroxy-3'-4'- dimethylazobenzene

The reductive voltammetric and polarographic behaviour of the 3-allyl-4-hydroxy-3'-4'-dimethylazobenzene at a hanging mercury drop electrode (HMDE) and static mercury drop electrode (SMDE) has been studied in Britton-Robinson (B-R) buffers in the pH range of 2.0-12.0. The 3-allyl-4-hydroxy-3'-4'-dimethylazobenzene gave one voltammetric and polarographic peak, corresponding to the reduction of the azo group to hydrazo and amine. The reduction process was found to be dependent on the pH of the supporting electrolyte. The reduction of the azo group to amino group in acidic media and hydrazo step in neutral and basic media was observed. From the observation an electrode reaction mechanism has been suggested for the compound. © 2013 by ESG

Psoriasis induced by tumor necrosis factor-alpha antagonist therapy: Case series and literature overview [Tümör nekrosis faktor-alfa i·nhibitörü kullanımına baglı olarak gelişen psöriazis: Olgu serisi ve literatürün gözden geçirilmesi]

Although tumor necrosis factor-alpha (TNF-?) antagonists are shown to be effective in the treatment of psoriasis, induction of psoriatic skin lesions have been seen in patients with different rheumatic conditions who were treated with TNF-? antagonists. In this case series, we report four cases that developed psoriatic lesions; in one of the cases, psoriasis was associated with two different TNF-? antagonists. Case 1: A 31-year-old man with ankylosing spondylitis developed erythematous and squamous lesions on his extremities in the 2nd week of infliximab treatment. Two months later he began to receive etanercept, and psoriatic skin lesions developed on the entire trunk and extremities, and predominantly on the scalp after one month. Case 2: A 53-year-old female with rheumatoid arthritis developed psoriatic skin lesions in the ankle region after two months' treatment with etanercept. Case 3: A 34-year-old female with ankylosing spondylitis developed psoriatic lesions on her palms after 10 months' treatment with infliximab. Case 4: A 40-year-old female with ankylosing spondylitis developed pustular lesions on her palms and soles after two years' treatment with infliximab. The patients had no personal or family history of psoriasis. The diagnosis of psoriasis was confirmed by skin biopsy in three of the cases. Psoriatic skin lesions can be induced as a result of treatment with TNF-? antagonists in patients with rheumatoid arthritis, ankylosing spondylitis and other spondyloarthropathies. The most common form is plaque or pustular pattern with palmoplantar distribution