KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation.

KDM2B (also known as FBXL10) controls stem cell self-renewal, somatic cell reprogramming and senescence, and tumorigenesis. KDM2B contains multiple functional domains, including a JmjC domain that catalyzes H3K36 demethylation and a CxxC zinc-finger that recognizes CpG islands and recruits the polycomb repressive complex 1. Here, we report that KDM2B, via its F-box domain, functions as a subunit of the CUL1-RING ubiquitin ligase (CRL1/SCF(KDM2B)) complex. KDM2B targets c-Fos for polyubiquitylation and regulates c-Fos protein levels. Unlike the phosphorylation of other SCF (SKP1-CUL1-F-box)/CRL1 substrates that promotes substrates binding to F-box, epidermal growth factor (EGF)-induced c-Fos S374 phosphorylation dissociates c-Fos from KDM2B and stabilizes c-Fos protein. Non-phosphorylatable and phosphomimetic mutations at S374 result in c-Fos protein which cannot be induced by EGF or accumulates constitutively and lead to decreased or increased cell proliferation, respectively. Multiple tumor-derived KDM2B mutations impaired the function of KDM2B to target c-Fos degradation and to suppress cell proliferation. These results reveal a novel function of KDM2B in the negative regulation of cell proliferation by assembling an E3 ligase to targeting c-Fos protein degradation that is antagonized by mitogenic stimulations

Void-mediated formation of Sn quantum dots in a Si matrix

Atomic scale analysis of Sn quantum dots (QDs) formed during the molecular beam-epitaxy (MBE) growth of Sn_xSi_(1−x) (0.05 ⩽ x ⩽ 0.1) multilayers in a Si matrix revealed a void-mediated formation mechanism. Voids below the Si surface are induced by the lattice mismatch strain between Sn_xSi_(1−x) layers and Si, taking on their equilibrium tetrakaidecahedron shape. The diffusion of Sn atoms into these voids leads to an initial rapid coarsening of quantum dots during annealing. Since this formation process is not restricted to Sn, a method to grow QDs may be developed by controlling the formation of voids and the diffusion of materials into these voids during MBE growth

Resilience Enhancement with Sequentially Proactive Operation Strategies

Extreme weather events, many of which are climate change related, are occurring with increasing frequency and intensity and causing catastrophic outages, reminding the need to enhance the resilience of power systems. This paper proposes a proactive operation strategy to enhance system resilience during an unfolding extreme event. The uncertain sequential transition of system states driven by the evolution of extreme events is modeled as a Markov process. At each decision epoch, the system topology is used to construct a Markov state. Transition probabilities are evaluated according to failure rates caused by extreme events. For each state, a recursive value function, including a current cost and a future cost, is established with operation constraints and intertemporal constraints. An optimal strategy is established by optimizing the recursive model, which is transformed into a mixed integer linear programming by using the linear scalarization method, with the probability of each state as the weight of each objective. The IEEE 30-bus system, the IEEE 118-bus system, and a realistic provincial power grid are used to validate the proposed method. The results demonstrate that the proposed proactive operation strategies can reduce the loss of load due to the development of extreme events.postprin

Primary anthropogenic aerosol emission trends for China, 1990–2005

An inventory of anthropogenic primary aerosol emissions in China was developed for 1990–2005 using a technology-based approach. Taking into account changes in the technology penetration within industry sectors and improvements in emission controls driven by stricter emission standards, a dynamic methodology was derived and implemented to estimate inter-annual emission factors. Emission factors of PM<sub>2.5</sub> decreased by 7%–69% from 1990 to 2005 in different industry sectors of China, and emission factors of TSP decreased by 18%–80% as well, with the measures of controlling PM emissions implemented. As a result, emissions of PM<sub>2.5</sub> and TSP in 2005 were 11.0 Tg and 29.7 Tg, respectively, less than what they would have been without the adoption of these measures. Emissions of PM<sub>2.5</sub>, PM<sub>10</sub> and TSP presented similar trends: they increased in the first six years of 1990s and decreased until 2000, then increased again in the following years. Emissions of TSP peaked (35.5 Tg) in 1996, while the peak of PM<sub>10</sub> (18.8 Tg) and PM<sub>2.5</sub> (12.7 Tg) emissions occurred in 2005. Although various emission trends were identified across sectors, the cement industry and biofuel combustion in the residential sector were consistently the largest sources of PM<sub>2.5</sub> emissions, accounting for 53%–62% of emissions over the study period. The non-metallic mineral product industry, including the cement, lime and brick industries, accounted for 54%–63% of national TSP emissions. There were no significant trends of BC and OC emissions until 2000, but the increase after 2000 brought the peaks of BC (1.51 Tg) and OC (3.19 Tg) emissions in 2005. Although significant improvements in the estimation of primary aerosols are presented here, there still exist large uncertainties. More accurate and detailed activity information and emission factors based on local tests are essential to further improve emission estimates, this especially being so for the brick and coke industries, as well as for coal-burning stoves and biofuel usage in the residential sector

Dielectric behaviour of graded spherical cells with an intrinsic dispersion

The dielectric properties of single-shell spherical cells with an intrinsic dielectric dispersion has been investigated. By means of the dielectric dispersion spectral representation (DDSR) for the Clausius-Mossotti (CM) factor, we express the dispersion strengths as well as the characteristic frequencies of the CM factor analytically in terms of the parameters of the cell model. These analytic expressions enable us to assess the influence of various model parameters on the electrokinetics of cells. Various interesting behaviours have been reported. We extend our considerations to a more realistic cell model with a graded core, which can have spatial gradients in the conductivity and/or permittivity. To this end, we address the effects of a graded profile in a small-gradient expansion in the framework of DDSR.Comment: accepted by European Physical Journal

Causality of the drought in the southwestern United States based on observations

Slow feature analysis is used to extract driving forces from the monthly mean anomaly time series of the precipitation in the southwestern United States (1895-2015). Four major spectral scales pass the 95% confidence test after wavelet analysis of the derived driving forces. Further harmonic analysis indicates that only two fundamental frequencies are dominant in the spectral domain. The frequencies represent the influence of the Pacific decadal oscillation (PDO) and solar activity on the precipitation from the southwestern United States. In addition, solar activity has exerted a greater effect than the PDO on the precipitation in the southwestern United States over the past 120 years. By comparing the trend of droughts with the two fundamental frequencies, it is found that both the droughts in the 1900s and in the twenty-first century were affected by the PDO and solar activity, whereas the droughts from the 1950s to the 1970s were mainly affected by solar activity

Highly ordered CdS nanoparticle arrays on silicon substrates and photoluminescence properties

Highly ordered cadmium sulphide (CdS) nanoparticle (NP) arrays were fabricated on silicon (Si) substrates using ultrathin alumina membranes as evaporation masks. The CdS NPs are polycrystalline and are composed of ultrasmall closely packed nanocrystallites. These crystallites increase in size as the duration of the CdS evaporation process increases. When the thickness of the NPs changes from about 10 to 50 nm, the size of the crystallites increases from about 5–14 to 20–40 nm. Photoluminescence measurements on the CdS NP arrays show a strong emission spectrum with two subbands that are attributed to band-edge and surface-defect emissions. The peak position and width of the band-edge emission band are closely related to the size of the crystallites in the CdS NPs.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87842/2/103106_1.pd

Using Megamaser Disks to Probe Black Hole Accretion

We examine the alignment between H_2O megamaser disks on sub-pc scales with circumnuclear disks and bars on <500 pc scales observed with HST/WFC3. The HST imaging reveals young stars, indicating the presence of gas. The megamaser disks are not well aligned with the circumnuclear bars or disks as traced by stars in the HST images. We speculate on the implications of the observed misalignments for fueling supermassive black holes in gas-rich spiral galaxies. In contrast, we find a strong preference for the rotation axes of the megamaser disks to align with radio continuum jets observed on >50 pc scales, in those galaxies for which radio continuum detections are available. Sub-arcsecond observations of molecular gas with ALMA will enable a more complete understanding of the interplay between circumnuclear structures.Comment: Error in Figure 4 corrected, references added. 7 pages, 4 figures, to be published in the Astrophysical Journa