20,329 research outputs found
Isospin-projected nuclear level densities by the shell model Monte Carlo method
We have developed an efficient isospin projection method in the shell model
Monte Carlo approach for isospin-conserving Hamiltonians. For isoscalar
observables this projection method has the advantage of being exact sample by
sample. The isospin projection method allows us to take into account the proper
isospin dependence of the nuclear interaction, thus avoiding a sign problem
that such an interaction introduces in unprojected calculations. We apply our
method in the calculation of the isospin dependence of level densities in the
complete shell. We find that isospin-dependent corrections to the
total level density are particularly important for nuclei.Comment: 5 pages including 4 figure
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Role of government policy in nutrition-barriers to and opportunities for healthier eating
Identification of a novel TSC2 c.3610Gā>āA, p.G1204R mutation contribute to aberrant splicing in a patient with classical tuberous sclerosis complex: a case report
Background: Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by hamartomas in
any organ systems. Mutations in the TSC1 or TSC2 gene lead to the dysfunction of hamartin or tuberin proteins,
which cause tuberous sclerosis complex.
Case presentation: We describe the clinical characteristics of patients from a Chinese family with tuberous sclerosis
complex and analyze the functional consequences of their causal genetic mutations. A novel heterozygous mutation
(c.3610G > A) at the last nucleotide of exon 29 in TSC2 was identified. On the protein level, this variant was presumed
to be a missense mutation (p.Gly1204Arg). However, the splicing assay revealed that this mutation also leads to the
whole TSC2 exon 29 skipping, besides the wild-type transcript. The mutated transcript results in an in-frame deletion of
71 amino acids (p.Gly1133_Thr1203del) and its ratio with the normal splice product is of about 44:56.
Conclusions: The novel c.3610G > A TSC2 mutation was identified in association with tuberous sclerosis complex. And
it was proven to code both for a missense-carrying transcript (56%), and for an isoform lacking exon 29 (44%)
Familial hypomagnesaemia, Hypercalciuria and Nephrocalcinosis associated with a novel mutation of the highly conserved leucine residue 116 of Claudin 16 in a Chinese patient with a delayed diagnosis: A case report
Background: Sixty mutations of claudin 16 coding gene have been reported in familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) patients. Recent investigations revealed that a highly conserved glycine-leucine-tryptophan (115G-L-W117) motif in the first extracellular segment (ESC1) of claudin 16 might be essential for stabilization of the appropriately folded ECS1 structure and conservation of normal claudin 16 function. However, neither missense nor nonsense mutation has ever been described in this motif. Our study aimed at identifying mutations in a Chinese patient with FHHNC and exploring the association between genotype and phenotype. Case presentation: A 33-year-old female presented with 4 years history of recurrent acute pyelonephritis without other notable past medical history. Her healthy parents, who aged 56 and 53 respectively, were second cousins, and her only sibling died from renal failure without definite cause at age 25. Renal ultrasound imaging demonstrated atrophic kidneys and bilateral nephrocalcinosis. The laboratory workup revealed impaired renal function (Stage CKD IV), hypocalcemia and mild hypomagnesemia, accompanied with marked renal loss of magnesium and hypercalciuria. During the follow-up, treatment with calcitriol and calcium but not with magnesium was difficult to achieve normal serum calcium levels, whereas her serum magnesium concentration fluctuated within normal ranges. In the end, the patient unavoidably reached ESRD at 36 years old. The clinical features and family history suggested the diagnosis of FHHNC. To make a definite diagnosis, we use whole-exome sequencing to identify the disease-causing mutations and Sanger sequencing to confirm the mutation co-segregation in the family. As a result, a novel homozygous mutation (c.346C > G, p.Leu116Val) in115G-L-W117motif of claudin 16 was identified. Her parents, grandmother and one of her cousins carried heterozygous p.Leu116Val, whereas 200 unrelated controls did not carry this mutation. Conclusions: We described a delayed diagnosis patient with FHHNC in the Chinese population and identified a novel missense mutation in the highly conserved115G-L-W117motif of claudin 16 for the first time. According to the reported data and the information deduced from 3D modeling, we speculate that this mutation probably reserve partial residual function which might be related to the slight phenotype of the patient
SEPIA: Search for Proofs Using Inferred Automata
This paper describes SEPIA, a tool for automated proof generation in Coq.
SEPIA combines model inference with interactive theorem proving. Existing proof
corpora are modelled using state-based models inferred from tactic sequences.
These can then be traversed automatically to identify proofs. The SEPIA system
is described and its performance evaluated on three Coq datasets. Our results
show that SEPIA provides a useful complement to existing automated tactics in
Coq.Comment: To appear at 25th International Conference on Automated Deductio
Persistent X-Ray Photoconductivity and Percolation of Metallic Clusters in Charge-Ordered Manganites
Charge-ordered manganites of composition exhibit persistent photoconductivity upon
exposure to x-rays. This is not always accompanied by a significant increase in
the {\it number} of conduction electrons as predicted by conventional models of
persistent photoconductivity. An analysis of the x-ray diffraction patterns and
current-voltage characteristics shows that x-ray illumination results in a
microscopically phase separated state in which charge-ordered insulating
regions provide barriers against charge transport between metallic clusters.
The dominant effect of x-ray illumination is to enhance the electron {\it
mobility} by lowering or removing these barriers. A mechanism based on magnetic
degrees of freedom is proposed.Comment: 8 pages, 4 figure
On the optimality of gluing over scales
We show that for every , there exist -point metric spaces
(X,d) where every "scale" admits a Euclidean embedding with distortion at most
, but the whole space requires distortion at least . This shows that the scale-gluing lemma [Lee, SODA 2005] is tight,
and disproves a conjecture stated there. This matching upper bound was known to
be tight at both endpoints, i.e. when and , but nowhere in between.
More specifically, we exhibit -point spaces with doubling constant
requiring Euclidean distortion ,
which also shows that the technique of "measured descent" [Krauthgamer, et.
al., Geometric and Functional Analysis] is optimal. We extend this to obtain a
similar tight result for spaces with .Comment: minor revision
The Expression and Roles of Nde1 and Ndel1 in the Adult Mammalian Central Nervous System
Open Access funded by Wellcome Trust Under a Creative Commons license Acknowledgments We thank Prof Angelo Sementilli, Department of Pathology, Universidade Metropolitana de Santos, SP, Brazil, for the human sample collection. This study is funded by Scottish Universities Life Sciences Alliance (HR07019 to S. Shen and C.D. McCaig), Medical Research Scotland (384 FRG to B. Lang, United Kingdom), Tenovus Scotland (G12/25 to B. Lang), Sino-UK Higher Education Research Partnership for PhD Studies (C.D. McCaig and Y.Q. Ding) and Wellcome Trust (WT081633MA-NCE to P.J.A. McCaffery, United Kingdom).Peer reviewedPublisher PD
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