3,241 research outputs found
Real-time diagnostics of gas/water assisted injection moulding using integrated ultrasonic sensors
YesAn ultrasound sensor system has been applied to the mould of both the water and gas assisted
injection moulding processes. The mould has a cavity wall mounted pressure sensor and instrumentation to
monitor the injection moulding machine. Two ultrasound sensors are used to monitor the arrival of the fluid
(gas or water) bubble tip through the detection of reflected ultrasound energy from the fluid polymer
boundary and the fluid bubble tip velocity through the polymer melt is estimated. The polymer contact with
the cavity wall is observed through the reflected ultrasound energy from that boundary. A theoretically
based estimation of the residual wall thickness is made using the ultrasound reflection from the fluid (gas or
water) polymer boundary whilst the samples are still inside the mould and a good correlation with a physical
measurement is observed
High-fidelity Rydberg control-Z gates with time-optimal pulses
High-fidelity control- () gates are essential and mandatory to build
a large-scale quantum computer. In neutral atoms, the strong dipole-dipole
interactions between their Rydberg states make them one of the pioneering
platforms to implement gates. Here we numerically investigate the
time-optimal pulses to generate a high-fidelity Rydberg gate in a
three-level ladder-type atomic system. By tuning the temporal shapes of
Gaussian or segmented pulses, the populations on the intermediate excited
states are shown to be suppressed within the symmetric gate operation protocol,
which leads to a gate with a high Bell fidelity up to . These
optimized pulses are robust to thermal fluctuations and the excitation field
variations. Our results promise a high-fidelity and fast gate operation under
amenable and controllable experimental parameters, which goes beyond the
adiabatic operation regime under a finite Blockade strength.Comment: 6 figure
On the Miura map between the dispersionless KP and dispersionless modified KP hierarchies
We investigate the Miura map between the dispersionless KP and dispersionless
modified KP hierarchies. We show that the Miura map is canonical with respect
to their bi-Hamiltonian structures. Moreover, inspired by the works of Takasaki
and Takebe, the twistor construction of solution structure for the
dispersionless modified KP hierarchy is given.Comment: 19 pages, Latex, no figure
Generating scalable graph states in an atom-nanophotonic interface
Scalable graph states are essential for measurement-based quantum computation
and many entanglement-assisted applications in quantum technologies. Generation
of these multipartite entangled states requires a controllable and efficient
quantum device with delicate design of generation protocol. Here we propose to
prepare high-fidelity and scalable graph states in one and two dimensions,
which can be tailored in an atom-nanophotonic cavity via state carving
technique. We propose a systematic protocol to carve out unwanted state
components, which facilitates scalable graph states generations via adiabatic
transport of a definite number of atoms in optical tweezers. An analysis of
state fidelity is also presented, and the state preparation probability can be
optimized via multiqubit state carvings and sequential single-photon probes.
Our results showcase the capability of an atom-nanophotonic interface for
creating graph states and pave the way toward novel problem-specific
applications using scalable high-dimensional graph states with stationary
qubits.Comment: 5 figures with supplemental materia
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GPER-induced signaling is essential for the survival of breast cancer stem cells.
G protein-coupled estrogen receptor-1 (GPER), a member of the G protein-coupled receptor (GPCR) superfamily, mediates estrogen-induced proliferation of normal and malignant breast epithelial cells. However, its role in breast cancer stem cells (BCSCs) remains unclear. Here we showed greater expression of GPER in BCSCs than non-BCSCs of three patient-derived xenografts of ER- /PR+ breast cancers. GPER silencing reduced stemness features of BCSCs as reflected by reduced mammosphere forming capacity in vitro, and tumor growth in vivo with decreased BCSC populations. Comparative phosphoproteomics revealed greater GPER-mediated PKA/BAD signaling in BCSCs. Activation of GPER by its ligands, including tamoxifen (TMX), induced phosphorylation of PKA and BAD-Ser118 to sustain BCSC characteristics. Transfection with a dominant-negative mutant BAD (Ser118Ala) led to reduced cell survival. Taken together, GPER and its downstream signaling play a key role in maintaining the stemness of BCSCs, suggesting that GPER is a potential therapeutic target for eradicating BCSCs
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