Membangun Game Fun Animal Puzzle Menggunakan Algoritma Shuffle Random

Game adalah salah satu implementasi bidang ilmu komputer yang perkembangannya sudah sangat pesat. Game juga merupakan bentuk aplikasi yang edukatif, artinya bisa dijadikan sebagai media pembelajaran dimana prosesnya bisa dilakukan dengan konsep belajar sambil bermain untuk anak-anak. Fun Animal Puzzle adalah permainan berjenis Drag and Drop Puzzle dan Match-Up Puzzle yang dirancang untuk mengasah ketepatan dan daya ingat anak. Dalam permainan ini pemain harus memasangkan potongan gambar yang sama dan mencocokkan dua gambar yang sama, pemain harus mengingat posisi gambar yang akan dicocokkan. Dalam penelitian ini metode yang digunakan untuk merancang perangkat lunak adalah metode pengembangan multimedia yang terdiri dari concept, design, material collecting, assembly, testing, dan distribution. Algoritma yang digunakan adalah pengacakan shuffle dimana pemain tidak dapat menghapal posisi gambar bermain dan membuat permainan tidak membosankan serta mampu menerapkan sistem belajar sambil bermain dan menjadi metode pembelajaran yang baik di kalangan anak-anak. dengan tujuan memberikan proses pembelajaran yang baik dan efektif. penelitian ini diharapkan dapat meningkatkan ketangkasan dan imajinasi anak. Adapun hasil akhir dari penelitian ini adalah dengan adanya game ini dapat membantu untuk belajar mengingat, sehingga dapat melatih daya nalar dan daya ingat serta dapat digunakan sebagai sarana hiburan

Pengaruh Pengetahuan Peluang Kerja terhadap Keputusan Memilih Jurusan Siswa Smk Lkia Pontianak

This study aimed to determine the effect of knowledge about employment opportunities to the decision to choose majors in class X SMK LKIA Pontianak 2012-2013 school year. The research method used is associative method, with this form of research is the study of relationships. The sample in this study is a class X which numbered 108 people. There is positive knowledge of job opportunities to the decision to choose majors in class X SMK LKIA Pontianak. Based on t count of 4.551 indicates that there is the influence of the independent variable ( X ) on the dependent variable ( Y ). When compared with the t table at 95 % significance level of 1.659. Then t is greater than t table or 4.551 > 1.659 so Ho is rejected and Ha accepted. Calculation of simple linear regression equation obtained X. Y = 33.009 +0.289 Coefficient of Determination on the percentage contribution of this study demonstrate the effect of knowledge of job opportunities to the decision to choose majors at 16.3 %, while the rest is influenced by other variables

Peningkatan Effisiensi Elektrik Modul Surya Menggunakan Bahan Berubah Fasa dan Maximum Power Point Tracking (MPPT)

Pemanfaatan Modul Surya (Photovoltaic-PV) untuk membangkitkan daya elektrik terkendala oleh efisiensi yang masih rendah. Efisiensi elektrik tersebut juga akan turun seiring dengan peningkatan temperatur sel PV selama PV beroperasi. Penggunaan Crude Palm Oil (CPO) sebagai bahan berubah fasa (Phase Change Material-PCM) bertujuan untuk menghambat kenaikan temperatur sel-PV, sedangkan untuk mendapatkan daya maksimum dengan menggunakan Maximum Power Point Tracking (MPPT). Jurnal ini memuat hasil pengujian penggunaan PCM dan MPPT untuk meningkatkan efisiensi elektrik PV, dan dari hasil pengujian menunjukkan bahwa kombinasi antara PCM dan MPPT pada PV mampu meningkatkan efisiensi PV secara sigifikan dari 9,64% menjadi 16,27%

Correlation length of hydrophobic polyelectrolyte solutions

The combination of two techniques (Small Angle X-ray Scattering and Atomic Force Microscopy) has allowed us to measure in reciprocal and real space the correlation length $\xi$ of salt-free aqueous solutions of highly charged hydrophobic polyelectrolyte as a function of the polymer concentration $C_p$, charge fraction $f$ and chain length $N$. Contrary to the classical behaviour of hydrophilic polyelectrolytes in the strong coupling limit, $\xi$ is strongly dependent on $f$. In particular a continuous transition has been observed from $\xi \sim C_p^{-1/2}$ to $\xi\sim C_p^{-1/3}$ when $f$ decreased from 100% to 35%. We interpret this unusual behaviour as the consequence of the two features characterising the hydrophobic polyelectrolytes: the pearl necklace conformation of the chains and the anomalously strong reduction of the effective charge fraction.Comment: 7 pages, 5 figures, submitted to Europhysics Letter

Shapes, contact angles, and line tensions of droplets on cylinders

Using an interface displacement model we calculate the shapes of nanometer-size liquid droplets on homogeneous cylindrical surfaces. We determine effective contact angles and line tensions, the latter defined as excess free energies per unit length associated with the two contact lines at the ends of the droplet. The dependences of these quantities on the cylinder radius and on the volume of the droplets are analyzed.Comment: 26 pages, RevTeX, 10 Figure

Anisotropic colloids through non-trivial buckling

We present a study on buckling of colloidal particles, including experimental, theoretical and numerical developments. Oil-filled thin shells prepared by emulsion templating show buckling in mixtures of water and ethanol, due to dissolution of the core in the external medium. This leads to conformations with a single depression, either axisymmetric or polygonal depending on the geometrical features of the shells. These conformations could be theoretically and/or numerically reproduced in a model of homogeneous spherical thin shells with bending and stretching elasticity, submitted to an isotropic external pressure.Comment: submitted to EPJ

New potential antitumoral fluorescent tetracyclic thieno[3,2-b]pyridine derivatives: interaction with DNA and nanosized liposomes

Fluorescence properties of two new potential antitumoral tetracyclic thieno[3,2-b]pyridine derivatives were studied in solution and in liposomes of DPPC (dipalmitoyl phosphatidylcholine), egg lecithin (phosphatidylcholine from egg yolk; Egg-PC) and DODAB (dioctadecyldimethylammonium bromide). Compound 1, pyrido[2',3':3,2]thieno[4,5-d]pyrido[1,2-a]pyrimidin-6-one, exhibits reasonably high fluorescence quantum yields in all solvents studied (0.20 ≤ ΦF ≤ 0.30), while for compound 2, 3-[(p-methoxyphenyl)ethynyl]pyrido[2',3':3,2]thieno[4,5-d]pyrido[1,2-a]pyrimidin-6-one, the values are much lower (0.01 ≤ ΦF ≤ 0.05). The interaction of these compounds with salmon sperm DNA was studied using spectroscopic methods, allowing the determination of intrinsic binding constants, Ki = (8.7 ± 0.9) × 103 M-1 for compound 1 and Ki = (5.9 ± 0.6) × 103 M-1 for 2, and binding site sizes of n = 11 ± 3 and n = 7 ± 2 base pairs, respectively. Compound 2 is the most intercalative compound in salmon sperm DNA (35%), while for compound 1 only 11% of the molecules are intercalated. Studies of incorporation of both compounds in liposomes of DPPC, Egg-PC and DODAB revealed that compound 2 is mainly located in the hydrophobic region of the lipid bilayer, while compound 1 prefers a hydrated and fluid environment

Small-Molecule Activators of Insulin-Degrading Enzyme Discovered through High-Throughput Compound Screening

Background: Hypocatabolism of the amyloid β-protein (Aβ) by insulin-degrading enzyme (IDE) is implicated in the pathogenesis of Alzheimer disease (AD), making pharmacological activation of IDE an attractive therapeutic strategy. However, it has not been established whether the proteolytic activity of IDE can be enhanced by drug-like compounds. Methodology/Principal Findings: Based on the finding that ATP and other nucleotide polyphosphates modulate IDE activity at physiological concentrations, we conducted parallel high-throughput screening campaigns in the absence or presence of ATP and identified two compounds—designated Ia1 and Ia2—that significantly stimulate IDE proteolytic activity. Both compounds were found to interfere with the crosslinking of a photoaffinity ATP analogue to IDE, suggesting that they interact with a bona fide ATP-binding domain within IDE. Unexpectedly, we observed highly synergistic activation effects when the activity of Ia1 or Ia2 was tested in the presence of ATP, a finding that has implications for the mechanisms underlying ATP-mediated activation of IDE. Notably, Ia1 and Ia2 activated the degradation of Aβ by ∼700% and ∼400%, respectively, albeit only when Aβ was presented in a mixture also containing shorter substrates. Conclusions/Significance: This study describes the first examples of synthetic small-molecule activators of IDE, showing that pharmacological activation of this important protease with drug-like compounds is achievable. These novel activators help to establish the putative ATP-binding domain as a key modulator of IDE proteolytic activity and offer new insights into the modulatory action of ATP. Several larger lessons abstracted from this screen will help inform the design of future screening campaigns and facilitate the eventual development of IDE activators with therapeutic utility

How Are ‘Barack Obama’ and ‘President Elect’ Differentially Stored in the Brain? An ERP Investigation on the Processing of Proper and Common Noun Pairs

BACKGROUND:One of the most debated issues in the cognitive neuroscience of language is whether distinct semantic domains are differentially represented in the brain. Clinical studies described several anomic dissociations with no clear neuroanatomical correlate. Neuroimaging studies have shown that memory retrieval is more demanding for proper than common nouns in that the former are purely arbitrary referential expressions. In this study a semantic relatedness paradigm was devised to investigate neural processing of proper and common nouns. METHODOLOGY/PRINCIPAL FINDINGS:780 words (arranged in pairs of Italian nouns/adjectives and the first/last names of well known persons) were presented. Half pairs were semantically related ("Woody Allen" or "social security"), while the others were not ("Sigmund Parodi" or "judicial cream"). All items were balanced for length, frequency, familiarity and semantic relatedness. Participants were to decide about the semantic relatedness of the two items in a pair. RTs and N400 data suggest that the task was more demanding for common nouns. The LORETA neural generators for the related-unrelated contrast (for proper names) included the left fusiform gyrus, right medial temporal gyrus, limbic and parahippocampal regions, inferior parietal and inferior frontal areas, which are thought to be involved in the conjoined processing a familiar face with the relevant episodic information. Person name was more emotional and sensory vivid than common noun semantic access. CONCLUSIONS/SIGNIFICANCE:When memory retrieval is not required, proper name access (conspecifics knowledge) is not more demanding. The neural generators of N400 to unrelated items (unknown persons and things) did not differ as a function of lexical class, thus suggesting that proper and common nouns are not treated differently as belonging to different grammatical classes