2,032 research outputs found
A Note on the Generalization of the GEMS Approach
This paper is a supplement of our earlier work JHEP 0410 (2004)
011[gr-qc/0409107].We map the vector potential of charged black holes into GEMS
and find that its effect on the thermal spectrum is the same as that on the
black hole side, i.e., it will induce a chemical potential in the thermal
spectrum which is the same as that in the charged black holes.We also argue
that the generalization of GEMS approach to non-stationary motions is not
possible.Comment: Latex file, 10 pages, no figure; v2: minor corrections; v3: revised
with title changed, one new section added and references adde
Effects of relative orientation of the molecules on electron transport in molecular devices
Effects of relative orientation of the molecules on electron transport in
molecular devices are studied by non-equilibrium Green's function method based
on density functional theory. In particular, two molecular devices, with the
planer Au and Ag clusters sandwiched between the Al(100) electrodes
are studied. In each device, two typical configurations with the clusters
parallel and vertical to the electrodes are considered. It is found that the
relative orientation affects the transport properties of these two devices
completely differently. In the Al(100)-Au-Al(100) device, the conductance
and the current of the parallel configuration are much larger than those in the
vertical configuration, while in the Al(100)-Ag-Al(100) device, an
opposite conclusion is obtained
Temperature and time-dependent effects of delayed blood processing on oxylipin concentrations in human plasma.
BACKGROUND:Oxidized derivatives of polyunsaturated fatty acids, collectively known as oxylipins, are labile bioactive mediators with diverse roles in human physiology and pathology. Oxylipins are increasingly being measured in plasma collected in clinical studies to investigate biological mechanisms and as pharmacodynamic biomarkers for nutrient-based and drug-based interventions. Whole blood is generally stored either on ice or at room temperature prior to processing. However, the potential impacts of delays in processing, and of temperature prior to processing, on oxylipin concentrations are incompletely understood. OBJECTIVE:To evaluate the effects of delayed processing of blood samples in a timeframe that is typical of a clinical laboratory setting, using typical storage temperatures, on concentrations of representative unesterified oxylipins measured by liquid chromatography-tandem mass spectrometry. DESIGN:Whole blood (drawn on three separate occasions from a single person) was collected into 5 mL purple-top potassium-EDTA tubes and stored for 0, 10, 20, 30, 60 or 120 min at room temperature or on wet ice, followed by centrifugation at 4 °C for 10 min with plasma collection. Each sample was run in duplicate, therefore there were six tubes and up to six data points at each time point for each oxylipin at each condition (ice/room temperature). Representative oxylipins derived from arachidonic acid, docosahexaenoic acid, and linoleic acid were quantified by liquid chromatography tandem mass spectrometry. Longitudinal models were used to estimate differences between temperature groups 2 h after blood draw. RESULTS:We found that most oxylipins measured in human plasma in traditional potassium-EDTA tubes are reasonably stable when stored on ice for up to 2 h prior to processing, with little evidence of auto-oxidation in either condition. By contrast, in whole blood stored at room temperature, substantial time-dependent increases in the 12-lipoxygenase-derived (12-HETE, 14-HDHA) and platelet-derived (thromboxane B2) oxylipins were observed. CONCLUSION:These findings suggest that certain plasma oxylipins can be measured with reasonable accuracy despite delayed processing for up to 2 h when blood is stored on ice prior to centrifugation. 12-Lipoxygenase- and platelet-derived oxylipins may be particularly sensitive to post-collection artifact with delayed processing at room temperature. Future studies are needed to determine impacts of duration and temperature of centrifugation on oxylipin concentrations
Boty-like retrotransposons in the filamentous fungus Botrytis cinerea contain the additional antisense gene brtn
AbstractLong-terminal repeat (LTR) retrotransposons typically contain gag, pol, or gag–pol, and in some case env genes. In this work, we used data mining of the Botrytis cinerea genomic sequence and a molecular approach to identify Boty-like LTR retrotransposons in B. cinerea containing an antisense gene (brtn) between pol and the 3′-LTR. Reverse transcriptase PCR (RT-PCR) revealed that some brtn-like genes could be expressed, at least in B. cinerea T4. We conducted BLAST comparisons and conserved-domain analysis, but the function of putative BRTN is presently unknown. Boty-like LTR retrotransposons in Sclerotinia sclerotiorum, called ScscLRET and containing brtn homologs at positions similar to brtn, were detected by homology searches and data mining of the S. sclerotiorum 1980 genomic sequence. Thus, this study demonstrated that some fungal LTR retrotransposons contain additional antisense genes
Phenomenological Scaling of Rapidity Dependence for Anisotropic Flows in 25 MeV/nucleon Ca + Ca by Quantum Molecular Dynamics Model
Anisotropic flows (, , and ) of light fragments up till
the mass number 4 as a function of rapidity have been studied for 25
MeV/nucleon Ca + Ca at large impact parameters by Quantum
Molecular Dynamics model. A phenomenological scaling behavior of rapidity
dependent flow parameters (n = 1, 2, 3 and 4) has been found as a
function of mass number plus a constant term, which may arise from the
interplay of collective and random motions. In addition, keeps
almost independent of rapidity and remains a rough constant of 1/2 for all
light fragments.Comment: 4 pages, 5 figure
Classification of Bipartite and Tripartite Qutrit Entanglement under SLOCC
We classify biqutrit and triqutrit pure states under stochastic local
operations and classical communication. By investigating the right singular
vector spaces of the coefficient matrices of the states, we obtain explicitly
two equivalent classes of biqutrit states and twelve equivalent classes of
triqutrit states respectively.Comment: 10 page
An Empirical Approach to the Bond Additivity Model in Quantitative Interpretation of Sum Frequency Generation Vibrational Spectra
A complete empirical approach from known Raman and IR spectra is used to make
corrections to the bond additivity model for quantitative interpretation of Sum
Frequency generation Vibrational Spectra (SFG-VS) from molecular interfaces.
This empirical correction successfully addresses the failures of the simple
bond additivity model. This empirical approach not only provides new
understandings of the effectiveness and limitations of the bond additivity
model, but also provides a practical roadmap for its application in SFG-VS
studies of molecular interfaces
JCM-16021, a Chinese Herbal Formula, Attenuated Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome through Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in Rats
The present study aimed to investigate the analgesic effect of JCM-16021, a revised traditional Chinese herbal formula, on postinflammatory irritable bowel syndrome (PI-IBS) in rats. The trinitrobenzene sulfonic (TNBS) acid-induced PI-IBS model rats were orally administrated with different doses of JCM-16021 (1.2, 2.4, and 4.8 g/kg/d) for 14 consecutive days. The results showed that JCM-16021 treatment dose-dependently attenuated visceral hyperalgesia in PI-IBS rats. Further, the colonic enterochromaffin (EC) cell number, serotonin (5-HT) content, tryptophan hydroxylase expression, and mechanical-stimuli-induced 5-HT release were significantly ameliorated. Moreover, the decreased levels of mucosal cytokines in PI-IBS, especially the helper T-cell type 1- (Th1-) related cytokine TNF-α, were also elevated after JCM-16021 treatment. These data demonstrate that the analgesic effect of JCM-16021 on TNBS-induced PI-IBS rats may be medicated via reducing colonic EC cell hyperplasia and 5-HT availability
Electric field induced cis-to-trans isomerization of polyphenylacetylene in solid state
A field induced isomerization from cis to trans form in
stereoregular cis-rich polyphenylacetylenes (PPAs) was
found, and it provides an alternate method to control the
order of chromophores in thin solid films
Implications of new-onset atrial fibrillation on in-hospital and long-term prognosis of patients with acute myocardial infarction:A report from the CBD bank study
BACKGROUND: An increase in the incidence of atrial fibrillation (AF) during the acute phase of myocardial infarction (AMI) has been observed. But it is still unclear whether the implications of new-onset AF on in-hospital and long-term prognosis are of similar magnitude. METHODS: Using data from the CBD Bank study, 3,824 consecutive AMI patients, without prior AF, were analyzed. During the index hospitalization, all patients were monitored by continuous cardiac monitoring, twice daily performed 12- or 18-lead ECGs and timely ECG checks when cardiac symptoms occurred. Follow-up visits were routinely scheduled after discharge. Primary outcomes were all-cause death and cardiovascular death occurring during hospitalization and long-term follow-up. Secondary outcome was MACEs during hospitalization. RESULTS: During the median hospital stay of 9.0 (7.0, 11.0) days, new-onset AF was documented in 133 (3.48%) patients; 95 (71.43%) patients had AF attacks within 3 days following AMI. Independent risk factors associated with new-onset AF were older age, larger left atrial diameter, higher level of NT-proBNP, and primary PCI. New-onset AF was found to be significantly associated with in-hospital all-cause death (OR 4.33, 95%CI: 2.37-7.89, P < 0.001), cardiovascular death (OR 4.10, 95%CI: 2.18-7.73, P < 0.001), and MACEs (OR 2.51, 95%CI: 1.46-4.33, P = 0.001). A total of 112 new-onset AF and 3,338 non-AF patients were followed up for 1,090 (365, 1,694) days after discharge. There was no significant association between new-onset AF and long-term all-cause death (HR 1.21, 95%CI: 0.77-1.92, P = 0.406) or cardiovascular death (HR 1.09, 95%CI: 0.61-1.97, P = 0.764). CONCLUSION: New-onset AF following AMI is strongly associated with an increased risk of adverse in-hospital prognosis, but it does not affect prognosis in those who survive until hospital discharge
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