Identifikasi Panas Bumi Diwak dan Derekan Kecamatan Bergas Kabupaten Semarang dengan Menggunakan Metode Audiomagnetotellurik

Audio-Magnetotellurics (AMT) surveys has been conducted in September 2013 in the Diwak and Derekan geothermal fields. The purpose of the audio-magnetotelluric surveys to indicate heat source, reservoir, and cap rock. The data obtained from the field was apparent resistivity, phase difference, and coherence as a function of frequency are processed using softwere package WinGLink then matched with regional geological information studies, and the results are interpreted.Characterization of geothermal systems include the caprock with a resistivity of 0-10Ωm value where the area is a zone of conductivity. Then the reservoir area is suspected to have a resistivity value with arange of 50-500 Ωm with a depth of about 500 m. In the heat source located in a geothermal system resistivity values > 500Ωm with a depth of about 1.5 km

Interpretasi Geologi Bawah Permukaan Daerah Potensi Mata Air Panas Kaliulo Kabupaten Semarang Berdasarkan Data Geomagnet Menggunakan Model 2-d & 3-d

The geothermal hot springs has been discovered in the Kaliulo area, Pringapus district of Semarang Regency. The research was conducted by 2-D and 3-D model geomagnetic for find the geological subsurface structure. Observation data such as magnetic field of 61 point used one set of PPM (Proton Precission Magnetometer) GSM geometrics 19 T and two units Geotron Magnetometer Model Unit G5. Data analysis of geomagnet was undertaken by diurnal correction and IGRF (International Geomagnetic Reference Field) correction to obtain the total of magnetic field anomalies. The total magnetic field anomaly data were utilized to create anomaly contour. That anomaly is used for doing reduction to plansurface process, upward continuation that produce anomalies local and regional, and reduction to pole. Modeling was done on the local magnetic anomalies to review subsurface using Mag2DC and UBC Mag3D. The results showed the + (positive) closure and – (negative) closure that can indicate anomalies object in other word to be weak zone or geological structure of fault is available, so that the slicing is made on that closure. Based on the model 2-D normal fault structure the northwestsoutheast trending and northeast-southwest, this interpreting so that normal faults which controlled source hot springs Diwak to Kaliulo

Pemodelan Inversi Anomali Magnetik 3d Daerah Mata Air Panas Diwak dan Derekan

Research of magnetic methods that aim to interpretation the subsurface structure around the hot springs area Diwak and Derekan and to identification caused of hot springs Diwak and Derekan has been successfully carried out. In this research, measurements were taken at 97 points using a proton precession magnetometer (PPM) type of GSM model 19T geometrics and two Geotron Magnetometer G5 models to get the value of the total magnetic field. Measurement data is processed by the daily variation correction and correction IGRF (International Geomagnetic Reference Field) to get the value of the total magnetic field anomaly. Corrected data used to create contours of the total magnetic field anomaly. Contour total magnetic field anomaly is used for the reduction to plan surface process and upward continuation process. The results of the upward continuation get the contours of local anomaly and regional anomaly, the results of the local anomaly contour then reduced to the pole. Results of the research is a pair of positive and negative closure indicate a fault structure below the surface. There are two pairs of positive and negative closure which an incision is made to determine the subsurface structure by creating a 2D model using the software Mag2dc. 2D modeling results indicate the existence of a second incision fault structure in the form of down trending fault southwest-northeast. Meanwhile, to make 3D models using software Mag3D and 3D modeling results indicate the presence of fault structures below the surface. Fault zone results of 2D and 3D modeling is a media outlet fluid to the surface in the form of hot springs Diwak and Derekan

Penentuan Struktur Bawah Permukaan dengan Menggunakan Metode Seismik Refraksi di Lapangan Panas Bumi Diwak dan Derekan, Kecamatan Bergas, Kabupaten Semarang

A research of refraction seismic methods in Diwak and Derekan village, Bergas district , Semarang regency , Central Java has been done on March 30, 2013 and August 27, 2013. This research in order to determination the subsurface structure of a geothermal field Diwak and Derekan with refraction method. In this aquisision data the travel time data was a distance function, with Geometrics Model ES-3000 seismic refraction instrument with 8 Geophones. Processing and interpretation data used Hagiwara method. Hagiwara method used value of delay time concept from travel time curve.This interpretation which resulted shows the subsurface lithology of the study area Diwak v1 obtained for the first layer of 297 – 412 m/s which we interpret as a layer of alluvium. While v2 on both layers obtained a value of 471 – 697 m/s which we interpret as soil. This research is the penetration depth of 5.84 - 11.7 m . The results obtained in the field structure of the two bedding Derekan, v1 to the first layer of 546 - 1011 m/s which is interpreted as alluvium. While v2 on both layers obtained a value of 1081 - 1714 m/s are interpreted with clay .Penetration that can be recorded on the field at 0.75 – 9.16 m

Isolation of pulmonary veins using a thermoreactive implantable device with external energy transfer : evaluation in a porcine model

Background: Pulmonary vein isolation (PVI) is a well-established method for the treatment of symptomatic paroxysmal atrial fibrillation, but is only partly successful with a high rate of electrical reconnection. We introduce a novel technique in which PVI is accomplished by noninvasive heating of a dedicated thermoresponse implant inserted into the pulmonary veins (PV), demonstrated in a porcine model. Methods: A self-expanding nitinol-based implant was positioned in the common inferior PV of 11 pigs, using a fluoroscopy-guided transatrial appendage approach. Ablation was performed through contactless energy transfer from a primary extracorporal coil to a secondary heat ring (HR) embedded in the proximal part of the implant. Electrophysiological conduction was assessed prior to and postablation, and at 3 months. Histological samples were obtained acutely (n=4) and after 3 months (n=7). Results: In total, 13 PV implants were successfully positioned in the inferior PVs of 11 animals. Ablation was performed without injury of adjacent structures. PVI and bidirectional block was electrophysiologically confirmed in all cases immediately at the time of implantation and 3 months later in seven chronic animals in whom testing was repeated. Marked evidence of ablation around the proximal HR was evident at 3 months postprocedure, with scar tissue formation and only mild neointimal proliferation. Conclusions: Successful PVI can be obtained by external electromagnetic heat transfer to a novel pulmonary vein implant

Submicron Structures Technology and Research

Contains reports on fifteen research projects.Joint Services Electronics Program (Contract DAALO3-86-K-0002)National Science Foundation (Grant ECS 87-09806)Semiconductor Research Corporation (Contract 87-SP-080)National Science Foundation (Grant ECS 85-03443)U.S. Air Force - Office of Scientific Research (Grant AFOSR 85-0376)National Science Foundation (Grant ECS 85-06565)U.S. Air Force - Office of Scientific Research (Grant AFOSR 85-0154)Lawrence Livermore National Laboratory (Subcontract 2069209)National Aeronautics and Space Adminstration (Grant NGL22-009-683)Collaboration with KMS Fusion, Inc

Prediction of acute multiple sclerosis relapses by transcription levels of peripheral blood cells

<p>Abstract</p> <p>Background</p> <p>The ability to predict the spatial frequency of relapses in multiple sclerosis (MS) would enable physicians to decide when to intervene more aggressively and to plan clinical trials more accurately.</p> <p>Methods</p> <p>In the current study our objective was to determine if subsets of genes can predict the time to the next acute relapse in patients with MS. Data-mining and predictive modeling tools were utilized to analyze a gene-expression dataset of 94 non-treated patients; 62 patients with definite MS and 32 patients with clinically isolated syndrome (CIS). The dataset included the expression levels of 10,594 genes and annotated sequences corresponding to 22,215 gene-transcripts that appear in the microarray.</p> <p>Results</p> <p>We designed a two stage predictor. The first stage predictor was based on the expression level of 10 genes, and predicted the time to next relapse with a resolution of 500 days (error rate 0.079, p < 0.001). If the predicted relapse was to occur in less than 500 days, a second stage predictor based on an additional different set of 9 genes was used to give a more accurate estimation of the time till the next relapse (in resolution of 50 days). The error rate of the second stage predictor was 2.3 fold lower than the error rate of random predictions (error rate = 0.35, p < 0.001). The predictors were further evaluated and found effective both for untreated MS patients and for MS patients that subsequently received immunomodulatory treatments after the initial testing (the error rate of the first level predictor was < 0.18 with p < 0.001 for all the patient groups).</p> <p>Conclusion</p> <p>We conclude that gene expression analysis is a valuable tool that can be used in clinical practice to predict future MS disease activity. Similar approach can be also useful for dealing with other autoimmune diseases that characterized by relapsing-remitting nature.</p

Cross-recognition of a pit viper (Crotalinae) polyspecific antivenom explored through high-density peptide microarray epitope mapping

Snakebite antivenom is a 120 years old invention based on polyclonal mixtures of antibodies purified from the blood of hyper-immunized animals. Knowledge on antibody recognition sites (epitopes) on snake venom proteins is limited, but may be used to provide molecular level explanations for antivenom cross-reactivity. In turn, this may help guide antivenom development by elucidating immunological biases in existing antivenoms. In this study, we have identified and characterized linear elements of B-cell epitopes from 870 pit viper venom protein sequences by employing a high-throughput methodology based on custom designed high-density peptide microarrays. By combining data on antibody-peptide interactions with multiple sequence alignments of homologous toxin sequences and protein modelling, we have determined linear elements of antibody binding sites for snake venom metalloproteases (SVMPs), phospholipases A2s (PLA2s), and snake venom serine proteases (SVSPs). The studied antivenom antibodies were found to recognize linear elements in each of the three enzymatic toxin families. In contrast to a similar study of elapid (non-enzymatic) neurotoxins, these enzymatic toxins were generally not recognized at the catalytic active site responsible for toxicity, but instead at other sites, of which some are known for allosteric inhibition or for interaction with the tissue target. Antibody recognition was found to be preserved for several minor variations in the protein sequences, although the antibody-toxin interactions could often be eliminated completely by substitution of a single residue. This finding is likely to have large implications for the cross-reactivity of the antivenom and indicate that multiple different antibodies are likely to be needed for targeting an entire group of toxins in these recognized sites.Novo Nordisk Foundation/[NNF13OC0005613]/NNF/DinamarcaNovo Nordisk Foundation/[NNF16OC0019248]/NNF/DinamarcaUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP