GOLF SWING MOTION ANALYSIS: CHALLENGES AND SOLUTIONS

With advanced motion capture technologies available, the scope and depth of motion analysis now is mainly limited by the capability of the analysis software. Golf swing analysis requires advanced motion analysis methods such as detection of the true impact instant, computation of the impact conditions, definition and use of local reference frames (body and club) in various ways, and determination and use of the functional swing plane. The purpose of this paper was to identify and present solutions for the unique challenges encountered in golf swing motion analysis and to demonstrate the application of such solutions by using Kwon3D, a comprehensive motion analysis program

Generalized conductance sum rule in atomic break junctions

When an atomic-size break junction is mechanically stretched, the total conductance of the contact remains approximately constant over a wide range of elongations, although at the same time the transmissions of the individual channels (valence orbitals of the junction atom) undergo strong variations. We propose a microscopic explanation of this phenomenon, based on Coulomb correlation effects between electrons in valence orbitals of the junction atom. The resulting approximate conductance quantization is closely related to the Friedel sum rule.Comment: 4 pages, 1 figure, appears in Proceedings of the NATO Advanced Research Workshop ``Size dependent magnetic scattering'', Pecs, Hungary, May 28 - June 1, 200

Routing in Point-to-Point Delivery Systems

This paper was also printed as a Working Paper at the Yale School of Organization and Management, Series B, No. 103.We develop an optimization-based approach for a point-to-point route planning problem that arises in many large scale delivery systems(for example, less-than-truckload freight, rail, mail and package delivery, communications). In these settings, a firm which must ship goods between many origin and destination pairs on a network needs to specify a route for each origin-destination pair so as to minimize transportation costs and/or transit times. Typically, the cost structure is very complicated. The approach discussed in this paper exploits the structure of the problem to decompose it into two smaller subproblems, each amenable to solution by a combination of optimization and heuristic techniques. One subproblem is an 'assignment' problem with capacity constraints. The other subproblem is a mixed-integer multicommodity flow problem. We propose solution methods based on Lagrangian relaxation for each subproblem. Computational results with these methods and with a heuristic procedure for the multicommodity flow problem on a problem met in practice are encouraging and suggest that mathematical programming methods can be successfully applied to large-scale problems in delivery systems planning and other problems in logistical system design

IQGAP1 regulates actin cytoskeleton organization in podocytes through interaction with nephrin

Increasing data has shown that the cytoskeletal reorganization of podocytes is involved in the onset of proteinuria and the progression of glomerular disease. Nephrin behaves as a signal sensor of the slit diaphragm to transmit cytoskeletal signals to maintain the unique structure of podocytes. However, the nephrin signaling cascade deserves further study. IQGAP1 is a scaffolding protein with the ability to regulate cytoskeletal organization. It is hypothesized that IQGAP1 contributes to actin reorganization in podocytes through interaction with nephrin. IQGAP1 expression and IQGAP1-nephrin colocalization in glomeruli were progressively decreased and then gradually recovered in line with the development of foot process fusion and proteinuria in puromycin aminonucleoside-injected rats. In cultured human podocytes, puromycin aminonudeoside-induced disruption of F-actin and disorders of migration and spreading were aggravated by IQGAP1 siRNA, and these effects were partially restored by a wild-type IQGAP1 plasmid. Furthermore, the cytoskeletal disorganization stimulated by cytochalasin D in COS7 cells was recovered by cotransfection with wild-type IQGAP1 and nephrin plasmids but was not recovered either by single transfection of the wild-type IQGAP1 plasmid or by cotransfection of mutant IQGAP1 [Delta 1443(S -\u3e A)] and wild-type nephrin plasmids. Co-immunoprecipitation analysis using lysates of COS7 cells overexpressing nephrin and each derivative-domain molecule of IQGAP1 demonstrated that the poly-proline binding domain and RasGAP domain in the carboxyl terminus of IQGAP1 are the target modules that interact with nephrin. Collectively, these findings showed that activated IQGAP1, as an intracellular partner of nephrin, is involved in actin cytoskeleton organization and functional regulation of podocytes. (c) 2015 Elsevier Inc. All rights reserved

Rates and Determinants of Mother\u27s Own Milk Feeding in Infants Born Very Preterm

Objectives: To examine rates and determinants of mother\u27s own milk (MOM) feeding at hospital discharge in a cohort of infants born very preterm within the Canadian Neonatal Network (CNN). Study design: This was a population-based cohort study of infants born at (NICUs) participating in the CNN between January 1, 2015, and December 31, 2018. We examined the rates and determinants of MOM use at discharge home among the participating NICUs. We used multivariable logistic regression analysis to identify independent determinants of MOM feeding. Results: Among the 6404 infants born very preterm and discharged home during the study period, 4457 (70%) received MOM or MOM supplemented with formula. Rates of MOM feeding at discharge varied from 49% to 87% across NICUs. Determinants associated with MOM feeding at discharge were gestational age 29-32 weeks compared with (aOR 1.56, 95% CI 1.25-1.93), primipara mothers (aOR 2.12, 95% CI 1.86-2.42), maternal diabetes (aOR 0.79, 95% CI 0.66-0.93), and maternal smoking (aOR 0.27, 95% CI 0.19-0.38). Receipt of MOM by day 3 of age was the major predictor of breast milk feeding at discharge (aOR 3.61, 95% CI 3.17-4.12). Conclusions: Approximately two-thirds of infants born very preterm received MOM at hospital discharge, and rates varied across NICUs. Supporting mothers to provide breast milk in the first 3 days after birth may be associated with improved MOM feeding rates at discharge

Using Neural Networks for Relation Extraction from Biomedical Literature

Using different sources of information to support automated extracting of relations between biomedical concepts contributes to the development of our understanding of biological systems. The primary comprehensive source of these relations is biomedical literature. Several relation extraction approaches have been proposed to identify relations between concepts in biomedical literature, namely, using neural networks algorithms. The use of multichannel architectures composed of multiple data representations, as in deep neural networks, is leading to state-of-the-art results. The right combination of data representations can eventually lead us to even higher evaluation scores in relation extraction tasks. Thus, biomedical ontologies play a fundamental role by providing semantic and ancestry information about an entity. The incorporation of biomedical ontologies has already been proved to enhance previous state-of-the-art results.Comment: Artificial Neural Networks book (Springer) - Chapter 1

The SOS Pilot Study: a RCT of routine oxygen supplementation early after acute stroke—effect on recovery of neurological function at one week

Mild hypoxia is common after stroke and associated with poor long-term outcome. Oxygen supplementation could prevent hypoxia and improve recovery. A previous study of routine oxygen supplementation showed no significant benefit at 7 and 12 months. This pilot study reports the effects of routine oxygen supplementation for 72 hours on oxygen saturation and neurological outcomes at 1 week after a stroke

Enhanced Production of Thermostable Pullulanase Type 1 Using Bacillus cereus FDTA 13 and Its Mutant

U ovom je radu opisano optimiranje uvjeta uzgoja za proizvodnju termostabilne pululanaze iz novog soja bakterije Bacillus cereus FDTA 13, izoliranog iz zemlje s plantaže tapioke. Primjenom jednofaktorijalne i ortogonalne metode optimirana je jednostavna podloga od najmanjeg broja djelotvornih sastojaka za maksimalnu proizvodnju pululanaze. Optimiranom podlogom sastava (u g/L): škrob 20, kvaščev ekstrakt 5, NaCl 2, MgSO4 0,1 i K2HPO4 0,17 postignuta je skoro 3,6 puta veca aktivnost pululanaze. Dodatkom iona Mn2+ optimiranoj podlozi proizvodnja je povecana 1,4 puta. Istražen je utjecaj proteolitičkih inhibitora na stabilnost pululanaze u podlozi. Mutant bakterije Bacillus cereus FDTA 13/NTG04-B4, dobiven kemijskom mutacijom roditeljskog soja, dvostruko je povećao proizvodnju pululanaze u optimiranoj podlozi pa je dobiveni prinos sličan onom dobivenom primjenom roditeljskog soja u podlozi s manjom koncentracijom izvora ugljika.This paper describes optimization of fermentation conditions for the production of thermostable pullulanase from a new strain Bacillus cereus FDTA 13, isolated from tapioca soil. By using one-factor-at-a-time and orthogonal array method, a simple medium with effective and minimal components was optimized for maximal pullulanase production. The optimized medium containing (in g/L): starch 20, yeast extract 5, NaCl 2, MgSO4 0.1 and K2HPO4 0.17 gave nearly 3.6-fold increase in pullulanase activity. Addition of Mn2+ ions in the optimized medium further enhanced the production by 1.4-fold. Effects of proteolytic inhibitors on stability of pullulanase in the medium were studied. A mutant Bacillus cereus FDTA 13/NTG04-B4, obtained by chemical mutation of the parent strain, further increased the pullulanase production by 2-fold in optimized medium, and gave similar yield as the parent strain in a medium with lower levels of carbon source