4,549 research outputs found
The changing frequency of Type 1 diabetes-associated genes over time:Insights into how our changing environment influences risk
Comment on "Groverian Entanglement Measure and Evolution of Entanglement in Search Algorithm for n(= 3, 5)-Qubit Systems with Real Coefficients" (Volume 6, Number 4, August 2007), by Arti Chamoli and C. M. Bhandari
We point out that the main results-the analytic expressions for the Groverian
Measure of Entanglement, in the above mentioned paper are erroneous. The
technical mistake of the paper is discussed. It is shown by an explicit example
that the formula for calculating the Groverian measure yields G(|\psi>) = 0 for
some entangled states.Comment: 4 pages, published online in Quantum Info. Process. on 24 July 200
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Leveraging legacy codes to distributed problem solving environments: A web service approach
This paper describes techniques used to leverage high performance legacy codes as CORBA components to a distributed problem solving environment. It first briefly introduces the software architecture adopted by the environment. Then it presents a CORBA oriented wrapper generator (COWG) which can be used to automatically wrap high performance legacy codes as CORBA components. Two legacy codes have been wrapped with COWG. One is an MPI-based molecular dynamic simulation (MDS) code, the other is a finite element based computational fluid dynamics (CFD) code for simulating incompressible Navier-Stokes flows. Performance comparisons between runs of the MDS CORBA component and the original MDS legacy code on a cluster of workstations and on a parallel computer are also presented. Wrapped as CORBA components, these legacy codes can be reused in a distributed computing environment. The first case shows that high performance can be maintained with the wrapped MDS component. The second case shows that a Web user can submit a task to the wrapped CFD component through a Web page without knowing the exact implementation of the component. In this way, a user’s desktop computing environment can be extended to a high performance computing environment using a cluster of workstations or a parallel computer
Dimeric 2G12 as a Potent Protection against HIV-1
We previously showed that broadly neutralizing anti-HIV-1 antibody 2G12 (human IgG1) naturally forms dimers that are more potent than monomeric 2G12 in in vitro neutralization of various strains of HIV-1. In this study, we have investigated the protective effects of monomeric versus dimeric 2G12 against HIV-1 infection in vivo using a humanized mouse model. Our results showed that passively transferred, purified 2G12 dimer is more potent than 2G12 monomer at preventing CD4 T cell loss and suppressing the increase of viral load following HIV-1 infection of humanized mice. Using humanized mice bearing IgG “backpack” tumors that provided 2G12 antibodies continuously, we found that a sustained dimer concentration of 5–25 µg/ml during the course of infection provides effective protection against HIV-1. Importantly, 2G12 dimer at this concentration does not favor mutations of the HIV-1 envelope that would cause the virus to completely escape 2G12 neutralization. We have therefore identified dimeric 2G12 as a potent prophylactic reagent against HIV-1 in vivo, which could be used as part of an antibody cocktail to prevent HIV-1 infection
Multiple solutions for slip effects on dissipative magneto-nanofluid transport phenomena in porous media : stability analysis
The present paper considers a numerical investigation of transport phenomena in electricallyconducting nanofluid flow within a porous bed utilizing Buongiorno’s transport model and Runge-Kutta-Fehlberg fourth-fifthorder method. Induced flow by non-isothermal stretching/shrinking sheet along with magnetic field impact, dissipation effect and slip conditions at the surface are also included. The numerical results show the existence of two branches of the solution for a selected range of the governing parameters. The physical significance of both branches of solutions is ensured by performing a stability analysis in which a linearized eigenvalue problem is solved. The multiple regression analysis with help of MALTAB LinearModel.fitpackage has also been conducted to estimate the dependency of the parameters on Nusselt number
An effective new iterative CG-method to solve unconstrained non-linear optimization issues
In this paper, we proposed a matrix-free double-search direction based on the updated parameter file of the double-search direction with a new mathematical formula for the gamma parameter. When comparing the numerical results of this algorithm with the standard (HWY) algorithm which given by Halilu, Waziri and Yusuf in 2020. We get very robust numerical results. The proposed algorithm is devoid of derivatives to solve large-scale non-linear problems by combining two search directions in one search direction. We demonstrated the overall convergence of the proposed algorithm under certain conditions. The numerical results presented in this paper show that the new search direction is useful for solving widespread non-linear test problems
Behaviour of engineered cementitious composite-encased stub concrete columns under axial compression
Although high-strength concrete (HSC) has higher compressive strength than normal-strength concrete (NSC), its application in column construction is often limited by its brittleness and limited post-peak ductility. In this preliminary study, hybrid fibre engineered cementitious composite (ECC) is proposed as a potential encasement material to confine the HSC core and to increase the column's ductility. The behaviours of the proposed ECC-encased concrete stub column under axial compression are studied experimentally. Thirty stub columns, including six NSC/HSC, six ECC and 18 ECC-encased NSC/HSC (ECC-NSC/HSC) are tested under axial compression. The effects of ECC strength, ECC encasement thickness, concrete strength and cross-section shapes (circular, square and rectangular) are then investigated and reported in terms of failure modes, strength ratios, post-peak ductility and energy dissipation capacity of the stub columns. It is found that, when comparing with NSC/HSC stub columns, although no significant improvement in the ultimate strength was observed, the ECC encasement improved the performance of ECC-NSC/HSC stub columns by reducing brittleness and improving the post-peak behaviour during failure
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