Diffusivity and Weak Clustering in a Quasi 2D Granular Gas

We present results from a detailed simulation of a quasi-2D dissipative granular gas, kept in a non-condensed steady state via vertical shaking over a rough substrate. This gas shows a weak power-law decay in the tails of its Pair Distribution Functions (PDF's), indicating fractality and therefore a tendency to form clusters over several size scales. This clustering depends monotonically on the dissipation coefficient, and disappears when the sphere-sphere collisions are conservative. Clustering is also sensitive to the packing fraction. This gas also displays the standard nonequilibrium characteristics of similar systems, including non-Maxwellian velocity distributions. The diffusion coefficients are calculated over all the conditions of the simulations, and it is found that diluted gases are more diffusive for smaller restitution coefficients.Comment: 14 pages, 11 figure

Optimizing CIGB-300 intralesional delivery in locally advanced cervical cancer

Background:We conducted a phase 1 trial in patients with locally advanced cervical cancer by injecting 0.5 ml of the CK2-antagonist CIGB-300 in two different sites on tumours to assess tumour uptake, safety, pharmacodynamic activity and identify the recommended dose.Methods:Fourteen patients were treated with intralesional injections containing 35 or 70 mg of CIGB-300 in three alternate cycles of three consecutive days each before standard chemoradiotherapy. Tumour uptake was determined using 99 Tc-radiolabelled peptide. In situ B23/nucleophosmin was determined by immunohistochemistry.Results:Maximum tumour uptake for CIGB-300 70-mg dose was significantly higher than the one observed for 35 mg: 16.1±8.9 vs 31.3±12.9 mg (P=0.01). Both, AUC 24h and biological half-life were also significantly higher using 70 mg of CIGB-300 (P<0.001). Unincorporated CIGB-300 diffused rapidly to blood and was mainly distributed towards kidneys, and marginally in liver, lungs, heart and spleen. There was no DLT and moderate allergic-like reactions were the most common systemic side effect with strong correlation between unincorporated CIGB-300 and histamine levels in blood. CIGB-300, 70 mg, downregulated B23/nucleophosmin (P=0.03) in tumour specimens.Conclusion:Intralesional injections of 70 mg CIGB-300 in two sites (0.5 ml per injection) and this treatment plan are recommended to be evaluated in phase 2 studies.Fil: Sarduy, M. R.. Medical-surgical Research Center; CubaFil: García, I.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Coca, M. A.. Clinical Investigation Center; CubaFil: Perera, A.. Clinical Investigation Center; CubaFil: Torres, L. A.. Clinical Investigation Center; CubaFil: Valenzuela, C. M.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Baladrón, I.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Solares, M.. Hospital Materno Ramón González Coro; CubaFil: Reyes, V.. Center For Genetic Engineering And Biotechnology Havana; CubaFil: Hernández, I.. Isotope Center; CubaFil: Perera, Y.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Martínez, Y. M.. Medical-surgical Research Center; CubaFil: Molina, L.. Medical-surgical Research Center; CubaFil: González, Y. M.. Medical-surgical Research Center; CubaFil: Ancízar, J. A.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Prats, A.. Clinical Investigation Center; CubaFil: González, L.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Casacó, C. A.. Clinical Investigation Center; CubaFil: Acevedo, B. E.. Centro de Ingeniería Genética y Biotecnología; CubaFil: López Saura, P. A.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Alonso, Daniel Fernando. Universidad Nacional de Quilmes; ArgentinaFil: Gómez, R.. Elea Laboratories; ArgentinaFil: Perea Rodríguez, S. E.. Center For Genetic Engineering And Biotechnology Havana; Cuba. Centro de Ingeniería Genética y Biotecnología; Cub

La opinión de la comunidad académica y estudiantil de la Universidad Autónoma del Estado de México en relación con su participación en la construcción de la agenda universitaria de poder

Este trabajo intentaconocer las formas y el grado de la participación política de la comunidad universitaria con visos de influir en la construcción de la agenda de poder. Implica las siguientes preguntas cruciales: ¿De qué manera la comunidad universitaria de la UAEM participa políticamente en la institución? ¿Qué tipo de participación, subjetiva/objetiva, informal/formal, y en qué grado, la comunidad analizada se involucra en actividades políticas

Challenges of Internet of Things and Big Data Integration

The Internet of Things anticipates the conjunction of physical gadgets to the In-ternet and their access to wireless sensor data which makes it expedient to restrain the physical world. Big Data convergence has put multifarious new opportunities ahead of business ventures to get into a new market or enhance their operations in the current market. considering the existing techniques and technologies, it is probably safe to say that the best solution is to use big data tools to provide an analytical solution to the Internet of Things. Based on the current technology deployment and adoption trends, it is envisioned that the Internet of Things is the technology of the future, while to-day's real-world devices can provide real and valuable analytics, and people in the real world use many IoT devices. Despite all the advertisements that companies offer in connection with the Internet of Things, you as a liable consumer, have the right to be suspicious about IoT advertise-ments. The primary question is: What is the promise of the Internet of things con-cerning reality and what are the prospects for the future.Comment: Proceedings of the International Conference on International Conference on Emerging Technologies in Computing 2018 (iCETiC '18), 23rd -24th August, 2018, at London Metropolitan University, London, UK, Published by Springer-Verla

Theory of transient spectroscopy of multiple quantum well structures

A theory of the transient spectroscopy of quantum well (QW) structures under a large applied bias is presented. An analytical model of the initial part of the transient current is proposed. The time constant of the transient current depends not only on the emission rate from the QWs, as is usually assumed, but also on the subsequent carrier transport across QWs. Numerical simulation was used to confirm the validity of the proposed model, and to study the transient current on a larger time scale. It is shown that the transient current is influenced by the nonuniform distribution of the electric field and related effects, which results in a step-like behavior of the current. A procedure of extraction of the QW emission time from the transient spectroscopy experiments is suggested.Comment: 5 pages, 4 figures, to be published in J. Appl. Phy

A review on nanomaterials and nanohybrids based bio-nanocomposites for food packaging

With an increasing demand for a novel, eco-friendly, high-performance packaging material “bio-nanocomposites” has attracted great attention in recent years. The review article aims at to evaluating recent innovation in bio-nanocomposites for food packaging applications. The current trends and research over the last three years of the various bio-nanocomposites including inorganic, organic nanomaterials, and nanohybrids, which are suitable as food packaging materials due to their advanced properties such as high mechanical, thermal, barrier, antimicrobial, and antioxidant are described in detail. In addition, the legislation, migration studies, and SWOT analysis on bio-nanocomposite film have been discussed. It has been observed that the multifunctional properties of the bio-nanocomposite materials, has the potential to improve the quality and safety of the food together with no /or fewer negative impact on the environment. However, more studies need to be performed on bionanocomposite materials to determine the migration levels and formulate relevant legislation

A Role for Phosphoinositides in Regulating Plant Nuclear Functions

Nuclear localized inositol phospholipids and inositol phosphates are important for regulating many essential processes in animal and yeast cells such as DNA replication, recombination, RNA processing, mRNA export and cell cycle progression. An overview of the current literature indicates the presence of a plant nuclear phosphoinositide (PI) pathway. Inositol phospholipids, inositol phosphates, and enzymes of the PI pathway have been identified in plant nuclei and are implicated in DNA replication, chromatin remodeling, stress responses and hormone signaling. In this review, the potential functions of the nuclear PI pathway in plants are discussed within the context of the animal and yeast literature. It is anticipated that future research will help shed light on the functional significance of the nuclear PI pathway in plants

Cold Plasma Technology in Food Packaging

Cold plasma (CP) is an effective strategy to alter the limitations of biopolymer materials for food packaging applications. Biopolymers such as polysaccharides and proteins are known to be sustainable materials with excellent film-forming properties. Bio-based films can be used as an alternative to traditional plastic packaging. There are limitations to biopolymer packaging materials such as hydrophobicity, poor barrier, and thermos-mechanical properties. For this reason, biopolymers must be modified to create a packaging material with the desired applicability. CP is an effective method to enhance the functionality and interfacial features of biopolymers. It etches the film surface allowing for better adhesion between various polymer layers while also improving ink printability. CP facilitates adhesion between two or more hydrophobic materials, resulting in significantly better water vapour permeability (WVP) properties. The sputtering of ionic species by CP results in cross-linkage reactions which improve the mechanical properties of films (tensile strength (TS) and elongation at break (EAB)). Cross-linkage reactions are reported to be responsible for the improved thermal stability of CP-treated biopolymers. CP treatment is known to decrease oxygen permeability (OP) in protein-based biopolymers. CP can also enable the blending of polymers with specific antimicrobial substances to develop active packaging materials. In this review article, we have presented an overview of the recent advancements of CP in the food packaging application. Furthermore, the influence of CP on the properties of packaging materials, and recent advancements in the modification of polymeric food packaging materials have been discussed

Clove essential oil and nanoclays-based active food packaging

Active food packaging materials enhance the shelf-life of food products while reducing food waste. The current study aims to develop a biodegradable active food packaging material. The food packaging material was developed with the incorporation of clove essential oil, sodium alginate, gelatin, and nanoclay films were prepared. The influences of nanoclay and clove on the surface, optical, mechanical, chemical, barrier, and pH-indicating properties were studied. The lightness and yellowness increased by 1.06 folds and 3.34 folds when compared to clove (control), respectively. The UV barrier property 0.08±0.01nm in all films, while 8.37 folds reduction in transparency has been observed as compared to clove films. The tensile strength was reduced by 62.25% while elongation at break increased by 2.23 folds when compared to NC (control) film. The surface roughness increased with the addition of NC. The hydrophobicity of the films has increased up to 85.64. Water vapour permeability increased by 8.25% and oxygen permeability increased by 67.61%. Complete E. coli and S. aureus inhibition at 24 hours in all films containing clove. Thus, the developed packaging film can be used as an active food packaging material that enhances food shelf-life

Nanoclays and Curcumin based food packaging material for intelligent food packaging applications

Bionanocomposite packaging eco-friendly alternatives with enhanced characteristics. This study aimed to develop a bionanocomposite intelligent packaging. Sodium alginate, gelatin, Curcumin (Cur), glycerol, and Nanoclay (NC) films were prepared. The influences of nanoclay and curcumin on the surface, optical, mechanical, chemical, barrier, and pH-indicating properties were studied. The results showed that the lightness of films was reduced by 1.28 folds compared to NC (control) film, while the yellowness of films increased by 5.82 folds. Film transparency was reduced by 9.3 folds and a 3.46 folds increase in UV barrier properties was observed compared to NC (control) film. The highest tensile strength and elongation at break was observed was 38.63±0.93MPa and 3.89±0.69%. The hydrophobicity of films increased upto 87.36. N-H, C-O, and O-H covalent bonds are observed between biopolymers. The water vapour barrier and oxygen permeability increased by 8.95% and 93.06% respectively when compared to Curcumin (control). A colour change was observed from orange to red in alkaline conditions. The biodegradation study showed that all developed films biodegraded 100% within 1 month. The films had enhanced mechanical, barrier, and pH-indicating properties. Therefore, it can be used as a potential intelligent food packaging material to improve the quality of food products