A heparin-mimicking polymer conjugate stabilizes basic fibroblast growth factor.

Basic fibroblast growth factor (bFGF) is a protein that plays a crucial role in diverse cellular functions, from wound healing to bone regeneration. However, a major obstacle to the widespread application of bFGF is its inherent instability during storage and delivery. Here, we describe the stabilization of bFGF by covalent conjugation with a heparin-mimicking polymer, a copolymer consisting of styrene sulfonate units and methyl methacrylate units bearing poly(ethylene glycol) side chains. The bFGF conjugate of this polymer retained bioactivity after synthesis and was stable to a variety of environmentally and therapeutically relevant stressors--such as heat, mild and harsh acidic conditions, storage and proteolytic degradation--unlike native bFGF. Following the application of stress, the conjugate was also significantly more active than the control conjugate system in which the styrene sulfonate units were omitted from the polymer structure. This research has important implications for the clinical use of bFGF and for the stabilization of heparin-binding growth factors in general

Negative-Parity Baryons in Quenched Anisotropic Lattice QCD

We study negative-parity baryon spectra in quenched anisotropic lattice QCD. The negative-parity baryons are measured as the parity partner of the ground-state baryons. In addition to the flavor octet and decuplet baryons, we pay much attention to the flavor-singlet negative-parity baryon as a three-quark state and compare it with the Lambda(1405) baryon. Numerical results of the flavor octet and decuplet negative-parity baryon masses are close to experimental values of lowest-lying negative-parity baryons, while the flavor-singlet baryon is much heavier than Lambda(1405). This indicates that the Lambda(1405) would be a multi-quark state such as the N-Kbar molecule rather than the flavor-singlet 3 quark state.Comment: 4 pages, 4 figs. Talk given at 16th International Conference on Particles and Nuclei (PANIC 02), Osaka, Japan, 30 Sep - 4 Oct 200

Equation of state in 2+1 flavor QCD with improved Wilson quarks by the fixed scale approach

We study the equation of state in 2+1 flavor QCD with nonperturbatively improved Wilson quarks coupled with the RG-improved Iwasaki glue. We apply the $T$-integration method to nonperturbatively calculate the equation of state by the fixed-scale approach. With the fixed-scale approach, we can purely vary the temperature on a line of constant physics without changing the system size and renormalization constants. Unlike the conventional fixed-$N_t$ approach, it is easy to keep scaling violations small at low temperature in the fixed scale approach. We study 2+1 flavor QCD at light quark mass corresponding to $m_\pi/m_\rho \simeq 0.63$, while the strange quark mass is chosen around the physical point. Although the light quark masses are heavier than the physical values yet, our equation of state is roughly consistent with recent results with highly improved staggered quarks at large $N_t$.Comment: 14 pages, 12 figures, v2: Table I and Figure 3 are corrected, reference updated. Main discussions and conclusions are unchanged, v3: version to appear in PRD, v4: reference adde

Near-periodic substitution and the genetic variance induced by environmental change

We investigate a model that describes the evolution of a diploid sexual population in a changing environment. Individuals have discrete generations and are subject to selection on the phenotypic value of a quantitative trait, which is controlled by a finite number of bialleic loci. Environmental change is taken to lead to a uniformly changing optimal phenotypic value. The population continually adapts to the changing environment, by allelic substitution, at the loci controlling the trait. We investigate the detailed interrelation between the process of allelic substitution and the adaptation and variation of the population, via infinite population calculations and finite population simulations. We find a simple relation between the substitution rate and the rate of change of the optimal phenotypic value

Non-Gaussian dephasing in flux qubits due to 1/f-noise

Recent experiments by F. Yoshihara et al. [Phys. Rev. Lett. 97, 167001 (2006)] and by K. Kakuyanagi et al. (cond-mat/0609564) provided information on decoherence of the echo signal in Josephson-junction flux qubits at various bias conditions. These results were interpreted assuming a Gaussian model for the decoherence due to 1/f noise. Here we revisit this problem on the basis of the exactly solvable spin-fluctuator model reproducing detailed properties of the 1/f noise interacting with a qubit. We consider the time dependence of the echo signal and conclude that the results based on the Gaussian assumption need essential reconsideration.Comment: Improved fitting parameters, new figur

Strategies for the evolution of sex

We find that the hypothesis made by Jan, Stauffer and Moseley [Theory in Biosc., 119, 166 (2000)] for the evolution of sex, namely a strategy devised to escape extinction due to too many deleterious mutations, is sufficient but not necessary for the successful evolution of a steady state population of sexual individuals within a finite population. Simply allowing for a finite probability for conversion to sex in each generation also gives rise to a stable sexual population, in the presence of an upper limit on the number of deleterious mutations per individual. For large values of this probability, we find a phase transition to an intermittent, multi-stable regime. On the other hand, in the limit of extremely slow drive, another transition takes place to a different steady state distribution, with fewer deleterious mutations within the asexual population.Comment: RevTeX, 11 pages, multicolumn, including 12 figure

Proton lifetime bounds from chirally symmetric lattice QCD

We present results for the matrix elements relevant for proton decay in Grand Unified Theories (GUTs). The calculation is performed at a fixed lattice spacing a^{-1}=1.73(3) GeV using 2+1 flavors of domain wall fermions on lattices of size 16^3\times32 and 24^3\times64 with a fifth dimension of length 16. We use the indirect method which relies on an effective field theory description of proton decay, where we need to estimate the low energy constants, \alpha = -0.0112(25) GeV^3 and \beta = 0.0120(26) GeV^3. We relate these low energy constants to the proton decay matrix elements using leading order chiral perturbation theory. These can then be combined with experimental bounds on the proton lifetime to bound parameters of individual GUTs.Comment: 17 pages, 9 Figure

Low-frequency noise as a source of dephasing of a qubit

With the growing efforts in isolating solid-state qubits from external decoherence sources, the material-inherent sources of noise start to play crucial role. One representative example is electron traps in the device material or substrate. Electrons can tunnel or hop between a charged and an empty trap, or between a trap and a gate electrode. A single trap typically produces telegraph noise and can hence be modeled as a bistable fluctuator. Since the distribution of hopping rates is exponentially broad, many traps produce flicker-noise with spectrum close to 1/f. Here we develop a theory of decoherence of a qubit in the environment consisting of two-state fluctuators, which experience transitions between their states induced by interaction with thermal bath. Due to interaction with the qubit the fluctuators produce 1/f-noise in the qubit's eigenfrequency. We calculate the results of qubit manipulations - free induction and echo signals - in such environment. The main problem is that in many important cases the relevant random process is both non-Markovian and non-Gaussian. Consequently the results in general cannot be represented by pair correlation function of the qubit eigenfrequency fluctuations. Our calculations are based on analysis of the density matrix of the qubit using methods developed for stochastic differential equations. The proper generating functional is then averaged over different fluctuators using the so-called Holtsmark procedure. The analytical results are compared with simulations allowing checking accuracy of the averaging procedure and evaluating mesoscopic fluctuations. The results allow understanding some observed features of the echo decay in Josephson qubits.Comment: 18 pages, 8 figures, Proc. of NATO/Euresco Conf. "Fundamental Problems of Mesoscopic Physics: Interactions and Decoherence", Granada, Spain, Sept.200