725 research outputs found
Range-Free Localization with the Radical Line
Due to hardware and computational constraints, wireless sensor networks
(WSNs) normally do not take measurements of time-of-arrival or
time-difference-of-arrival for rangebased localization. Instead, WSNs in some
applications use rangefree localization for simple but less accurate
determination of sensor positions. A well-known algorithm for this purpose is
the centroid algorithm. This paper presents a range-free localization technique
based on the radical line of intersecting circles. This technique provides
greater accuracy than the centroid algorithm, at the expense of a slight
increase in computational load. Simulation results show that for the scenarios
studied, the radical line method can give an approximately 2 to 30% increase in
accuracy over the centroid algorithm, depending on whether or not the anchors
have identical ranges, and on the value of DOI.Comment: Proc. IEEE ICC'10, Cape Town, South Africa, May, 201
In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice
Although tau is a cytoplasmic protein, it is also found in brain extracellular fluids, e.g., CSF. Recent findings suggest that aggregated tau can be transferred between cells and extracellular tau aggregates might mediate spread of tau pathology. Despite these data, details of whether tau is normally released into the brain interstitial fluid (ISF), its concentration in ISF in relation to CSF, and whether ISF tau is influenced by its aggregation are unknown. To address these issues, we developed a microdialysis technique to analyze monomeric ISF tau levels within the hippocampus of awake, freely moving mice. We detected tau in ISF of wild-type mice, suggesting that tau is released in the absence of neurodegeneration. ISF tau was significantly higher than CSF tau and their concentrations were not significantly correlated. Using P301S human tau transgenic mice (P301S tg mice), we found that ISF tau is fivefold higher than endogenous murine tau, consistent with its elevated levels of expression. However, following the onset of tau aggregation, monomeric ISF tau decreased markedly. Biochemical analysis demonstrated that soluble tau in brain homogenates decreased along with the deposition of insoluble tau. Tau fibrils injected into the hippocampus decreased ISF tau, suggesting that extracellular tau is in equilibrium with extracellular or intracellular tau aggregates. This technique should facilitate further studies of tau secretion, spread of tau pathology, the effects of different disease states on ISF tau, and the efficacy of experimental treatments
New high-efficiency source of photon pairs for engineering quantum entanglement
We have constructed an efficient source of photon pairs using a
waveguide-type nonlinear device and performed a two-photon interference
experiment with an unbalanced Michelson interferometer. Parametric
down-converted photons from the nonlinear device are detected by two detectors
located at the output ports of the interferometer. Because the interferometer
is constructed with two optical paths of different length, photons from the
shorter path arrive at the detector earlier than those from the longer path. We
find that the difference of arrival time and the time window of the coincidence
counter are important parameters which determine the boundary between the
classical and quantum regime. When the time window of the coincidence counter
is smaller than the arrival time difference, fringes of high visibility
(80 10%) were observed. This result is only explained by quantum theory
and is clear evidence for quantum entanglement of the interferometer's optical
paths.Comment: 4 pages, 4 figures, IQEC200
Modeling Recreation Demand When the Access Point Is Unknown
Not observing where an individual enters a geographically large recreation area complicates the task of modeling recreation demand. Traditionally, analysts have arbitrarily defined distances on the basis of the midpoint of a river or beach segment or on the basis of the nearest access point. In this article, we draw on the aggregation literature to generate a consistent framework for incorporating information on site characteristics and travel costs gathered at a finer level than that used to obtain trip counts. We use Monte Carlo experiments to illustrate the performance of the traditional midpoint and nearest access point approximations. Our results suggest that, while the nearest access point approach often provides a good approximation to underlying preferences, use of the midpoint approach can lead to significant bias in the travel cost parameter and corresponding welfare calculations. Finally, we use our approach to model recreation demand for the major river systems in Iowa using data from the 2009 Iowa Rivers and River Corridors Survey
Measurement of evaporation-residue cross sections with light beams and deformed lanthanide target nuclei
To obtain a better understanding of the fusion reaction, we have focused on reactions involving deformed nuclei. Evaporation residue cross sections of the 169Tm+20Ne reaction were measured, from which we extracted the fusion excitation function. This is compared with literature data of the 169Tm+16O and 165Ho+20Ne systems. Irradiation with 20Ne ion beam has been carried out at the incident energy near the Coulomb barrier, where the effect of nuclear deformation is prominent. The results are consistent with the idea that the degree of deformation has an effect on the threshold value of the excitation functions near the Coulomb barrier
Testing supersymmetry at the LHC through gluon-fusion production of a slepton pair
Renormalizable quartic couplings among new particles are typical of
supersymmetric models. Their detection could provide a test for supersymmetry,
discriminating it from other extensions of the Standard Model. Quartic
couplings among squarks and sleptons, together with the SU(3) gauge couplings
for squarks, allow a new realization of the gluon-fusion mechanism for
pair-production of sleptons at the one-loop level. The corresponding production
cross section, however, is at most of fb for slepton and squark
masses of GeV. We then extend our investigation to the
gluon-fusion production of sleptons through the exchange of Higgs bosons. The
cross section is even smaller, of fb, if the exchanged Higgs
boson is considerably below the slepton-pair threshold, but it is enhanced when
it is resonant. It can reach fb for the production of sleptons
of same-chirality, exceeding these values for 's of
opposite-chirality, even when chirality-mixing terms in the squark sector are
vanishing. The cross section can be further enhanced if these mixing terms are
nonnegligible, providing a potentially interesting probe of the Higgs sector,
in particular of parameters such as , , and .Comment: 28 pages, 11 figure
Identifying the target genes of SUPPRESSOR OF GAMMA RESPONSE 1, a master transcription factor controlling DNA damage response in Arabidopsis
In mammalian cells, the transcription factor p53 plays a crucial role in transmitting DNA damage signals to maintain genome integrity. However, in plants, orthologous genes for p53 and checkpoint proteins are absent. Instead, the plant-specific transcription factor SUPPRESSOR OF GAMMA RADIATION 1 (SOG1) controls most of the genes induced by gamma irradiation and promotes DNA repair, cell cycle arrest, and stem cell death. Thus far, the genes directly controlled by SOG1 remain largely unknown, limiting the understanding of DNA damage signaling in plants. Here, we conducted a microarray analysis and chromatin immunoprecipitation (ChIP)-sequencing, and identified 146 Arabidopsis genes as direct targets of SOG1. By using the ChIP-sequencing data, we extracted the palindromic motif [CTT(N)7AAG] as a consensus SOG1-binding sequence, which mediates target gene induction in response to DNA damage. Furthermore, DNA damage-triggered phosphorylation of SOG1 is required for efficient binding to SOG1-binding sequence. Comparison between SOG1 and p53 target genes showed that both transcription factors control genes responsible for cell cycle regulation, such as CDK inhibitors, and DNA repair proteins, whereas SOG1 preferentially targets genes involved in homologous recombination. We also found that defense-related genes were enriched in the SOG1 target genes. Consistent with this, SOG1 is required for resistance against the hemi-biotrophic fungus Colletotrichum higginsianum, suggesting that SOG1 has a unique function in controlling immune response. This article is protected by copyright. All rights reserved
Public Benefits of Undeveloped Lands on Urban Outskirts: Non-Market Valuation Studies and their Role in Land Use Plans
Over the past three decades, the economics profession has developed methods for estimating the public benefits of green spaces, providing an opportunity to incorporate such information into land-use planning. While federal regulations routinely require such estimates for major regulations, the extent to which they are used in local land use plans is not clear. This paper reviews the literature on public values for lands on urban outskirts, not just to survey their methods or empirical findings, but to evaluate the role they have played--or have the potential to play-- in actual land use plans. Based on interviews with authors and representatives of funding agencies and local land trusts, it appears that academic work has had a mixed reception in the policy world. Reasons for this include a lack of interest in making academic work accessible to policy makers, emphasizing revealed preference methods which are inconsistent with policy priorities related to nonuse values, and emphasis on benefit-cost analyses. Nevertheless, there are examples of success stories that illustrate how such information can play a vital role in the design of conservation policies. Working Paper 07-2
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