136 research outputs found
LOFAR Detection of 110-188 MHz Emission and Frequency-Dependent Activity from FRB 20180916B
FRB 20180916B is a well-studied repeating fast radio burst source. Its
proximity (~150 Mpc), along with detailed studies of the bursts, have revealed
many clues about its nature -- including a 16.3-day periodicity in its
activity. Here we report on the detection of 18 bursts using LOFAR at 110-188
MHz, by far the lowest-frequency detections of any FRB to date. Some bursts are
seen down to the lowest-observed frequency of 110 MHz, suggesting that their
spectra extend even lower. These observations provide an order-of-magnitude
stronger constraint on the optical depth due to free-free absorption in the
source's local environment. The absence of circular polarization and nearly
flat polarization angle curves are consistent with burst properties seen at
300-1700 MHz. Compared with higher frequencies, the larger burst widths
(~40-160 ms at 150 MHz) and lower linear polarization fractions are likely due
to scattering. We find ~2-3 rad/m^2 variations in the Faraday rotation measure
that may be correlated with the activity cycle of the source. We compare the
LOFAR burst arrival times to those of 38 previously published and 22 newly
detected bursts from the uGMRT (200-450 MHz) and CHIME/FRB (400-800 MHz).
Simultaneous observations show 5 CHIME/FRB bursts when no emission is detected
by LOFAR. We find that the burst activity is systematically delayed towards
lower frequencies by ~3 days from 600 MHz to 150 MHz. We discuss these results
in the context of a model in which FRB 20180916B is an interacting binary
system featuring a neutron star and high-mass stellar companion.Comment: Accepted for publication by ApJ
Menopausal Status Modifies Breast Cancer Risk Associated with the Myeloperoxidase (MPO) G463A Polymorphism in Caucasian Women: A Meta-Analysis
BACKGROUND: Breast cancer susceptibility may be modulated partly through polymorphisms in oxidative enzymes, one of which is myeloperoxidase (MPO). Association of the low transcription activity variant allele A in the G463A polymorphism has been investigated for its association with breast cancer risk, considering the modifying effects of menopausal status and antioxidant intake levels of cases and controls. METHODOLOGY/PRINCIPAL FINDINGS: To obtain a more precise estimate of association using the odds ratio (OR), we performed a meta-analysis of 2,975 cases and 3,427 controls from three published articles of Caucasian populations living in the United States. Heterogeneity among studies was tested and sensitivity analysis was applied. The lower transcriptional activity AA genotype of MPO in the pre-menopausal population showed significantly reduced risk (OR 0.56-0.57, p = 0.03) in contrast to their post-menopausal counterparts which showed non-significant increased risk (OR 1.14; p = 0.34-0.36). High intake of antioxidants (OR 0.67-0.86, p = 0.04-0.05) and carotenoids (OR 0.68-0.86, p = 0.03-0.05) conferred significant protection in the women. Stratified by menopausal status, this effect was observed in pre-menopausal women especially those whose antioxidant intake was high (OR 0.42-0.69, p = 0.04). In post-menopausal women, effect of low intake elicited susceptibility (OR 1.19-1.67, p = 0.07-0.17) to breast cancer. CONCLUSIONS/SIGNIFICANCE: Based on a homogeneous Caucasian population, the MPO G463A polymorphism places post-menopausal women at risk for breast cancer, where this effect is modified by diet
A Polymeric Liquid Membrane Electrode Responsive to 3,3′,5,5′-Tetramethylbenzidine Oxidation for Sensitive Peroxidase/Peroxidase Mimetic-Based Potentiometric Biosensing
Enzymatic oligomerization and polymerization of arylamines: state of the art and perspectives
The literature concerning the oxidative oligomerization and polymerization of various arylamines, e.g., aniline, substituted anilines, aminonaphthalene and its derivatives, catalyzed by oxidoreductases, such as laccases and peroxidases, in aqueous, organic, and mixed aqueous organic monophasic or biphasic media, is reviewed. An overview of template-free as well as template-assisted enzymatic syntheses of oligomers and polymers of arylamines is given. Special attention is paid to mechanistic aspects of these biocatalytic processes. Because of the nontoxicity of oxidoreductases and their high catalytic efficiency, as well as high selectivity of enzymatic oligomerizations/polymerizations under mild conditions-using mainly water as a solvent and often resulting in minimal byproduct formation-enzymatic oligomerizations and polymerizations of arylamines are environmentally friendly and significantly contribute to a "green'' chemistry of conducting and redox-active oligomers and polymers. Current and potential future applications of enzymatic polymerization processes and enzymatically synthesized oligo/polyarylamines are discussed
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