5,023 research outputs found
A Complete Model of Low-Scale Gauge Mediation
Recent signs of a Standard Model-like Higgs at 125 GeV point towards large
A-terms in the MSSM. This presents special challenges for gauge mediation,
which by itself predicts vanishing A-terms at the messenger scale. In this
paper, we review the general problems that arise when extending gauge mediation
to achieve large A-terms, and the mechanisms that exist to overcome them. Using
these mechanisms, we construct weakly-coupled models of low-scale gauge
mediation with extended Higgs-messenger couplings that generate large A-terms
at the messenger scale and viable mu/B_mu-terms. Our models are simple,
economical, and complete realizations of supersymmetry at the weak scale.Comment: 33 pages; v2: refs added, minor change
Left-right symmetry at LHC and precise 1-loop low energy data
Despite many tests, even the Minimal Manifest Left-Right Symmetric Model
(MLRSM) has never been ultimately confirmed or falsified. LHC gives a new
possibility to test directly the most conservative version of left-right
symmetric models at so far not reachable energy scales. If we take into account
precise limits on the model which come from low energy processes, like the muon
decay, possible LHC signals are strongly limited through the correlations of
parameters among heavy neutrinos, heavy gauge bosons and heavy Higgs particles.
To illustrate the situation in the context of LHC, we consider the "golden"
process . For instance, in a case of degenerate heavy neutrinos
and heavy Higgs masses at 15 TeV (in agreement with FCNC bounds) we get
fb at TeV which is consistent with muon
decay data for a very limited masses in the range (3008 GeV, 3040 GeV).
Without restrictions coming from the muon data, masses would be in the
range (1.0 TeV, 3.5 TeV). Influence of heavy Higgs particles themselves on the
considered LHC process is negligible (the same is true for the light, SM
neutral Higgs scalar analog). In the paper decay modes of the right-handed
heavy gauge bosons and heavy neutrinos are also discussed. Both scenarios with
typical see-saw light-heavy neutrino mixings and the mixings which are
independent of heavy neutrino masses are considered. In the second case heavy
neutrino decays to the heavy charged gauge bosons not necessarily dominate over
decay modes which include only light, SM-like particles.Comment: 16 pages, 10 figs, KL-KS and new ATLAS limits taken into accoun
Measuring the Invisible Higgs Width at the 7 and 8 TeV LHC
The LHC is well on track toward the discovery or exclusion of a light
Standard Model (SM)-like Higgs boson. Such a Higgs has a very small SM width
and can easily have large branching fractions to physics beyond the SM, making
Higgs decays an excellent opportunity to observe new physics. Decays into
collider-invisible particles are particularly interesting as they are
theoretically well motivated and relatively clean experimentally. In this work
we estimate the potential of the 7 and 8 TeV LHC to observe an invisible Higgs
branching fraction. We analyze three channels that can be used to directly
study the invisible Higgs branching ratio at the 7 TeV LHC: an invisible Higgs
produced in association with (i) a hard jet; (ii) a leptonic Z; and (iii)
forward tagging jets. We find that the last channel, where the Higgs is
produced via weak boson fusion, is the most sensitive, allowing branching
fractions as small as 40% to be probed at 20 inverse fb for masses in the range
between 120 and 170 GeV, including in particular the interesting region around
125 GeV. We provide an estimate of the 8 TeV LHC sensitivity to an
invisibly-decaying Higgs produced via weak boson fusion and find that the reach
is comparable to but not better than the reach at the 7 TeV LHC. We further
estimate the discovery potential at the 8 TeV LHC for cases where the Higgs has
substantial branching fractions to both visible and invisible final states.Comment: 23 pages, 7 figures. v2: version published in JHEP. 8 TeV analysis
adde
SUSY Stops at a Bump
We discuss collider signatures of the "natural supersymmetry" scenario with
baryon-number violating R-parity violation. We argue that this is one of the
few remaining viable incarnations of weak scale supersymmetry consistent with
full electroweak naturalness. We show that this intriguing and challenging
scenario contains distinctive LHC signals, resonances of hard jets in
conjunction with relatively soft leptons and missing energy, which are easily
overlooked by existing LHC searches. We propose novel strategies for
distinguishing these signals above background, and estimate their potential
reach at the 8 TeV LHC. We show that other multi-lepton signals of this
scenario can be seen by currently existing searches with increased statistics,
but these opportunities are more spectrum-dependent.Comment: 23 pages, 7 figures, 3 tables. V2: spectrum discussion corrected,
most of the changes are in Sec. 2. Benchmarks, analysis and conclusions
unchanged. References adde
How to look next? A data-driven approach for scanpath prediction
By and large, current visual attention models mostly rely, when considering static stimuli, on the following procedure. Given an image, a saliency map is computed, which, in turn, might serve the purpose of predicting a sequence of gaze shifts, namely a scanpath instantiating the dynamics of visual attention deployment. The temporal pattern of attention unfolding is thus confined to the scanpath generation stage, whilst salience is conceived as a static map, at best conflating a number of factors (bottom-up information, top-down, spatial biases, etc.). In this note we propose a novel sequential scheme that consists of a three-stage processing relying on a center-bias model, a context/layout model, and an object-based model, respectively. Each stage contributes, at different times, to the sequential sampling of the final scanpath. We compare the method against classic scanpath generation that exploits state-of-the-art static saliency model. Results show that accounting for the structure of the temporal unfolding leads to gaze dynamics close to human gaze behaviour
Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy
Mitophagy orchestrates the autophagic degradation of dysfunctional mitochondria preventing their pathological accumulation and contributing to cellular homeostasis. We previously identified a novel chemical tool (hereafter referred to as PMI), which drives mitochondria into autophagy without collapsing their membrane potential (ΔΨm). PMI is an inhibitor of the protein-protein interaction (PPI) between the transcription factor Nrf2 and its negative regulator, Keap1 and is able to up-regulate the expression of autophagy-associated proteins, including p62/SQSTM1. Here we show that PMI promotes mitochondrial respiration, leading to a superoxide-dependent activation of mitophagy. Structurally distinct Keap1-Nrf2 PPI inhibitors promote mitochondrial turnover, while covalent Keap1 modifiers, including sulforaphane (SFN) and dimethyl fumarate (DMF), are unable to induce a similar response. Additionally, we demonstrate that SFN reverses the effects of PMI in co-treated cells by reducing the accumulation of p62 in mitochondria and subsequently limiting their autophagic degradation. This study highlights the unique features of Keap1-Nrf2 PPI inhibitors as inducers of mitophagy and their potential as pharmacological agents for the treatment of pathological conditions characterized by impaired mitochondrial quality control
Revisiting soliton contributions to perturbative amplitudes
Open Access funded by SCOAP3. CP is
a Royal Society Research Fellow and partly supported by the U.S. Department of Energy
under grants DOE-SC0010008, DOE-ARRA-SC0003883 and DOE-DE-SC0007897. ABR
is supported by the Mitchell Family Foundation. We would like to thank the Mitchell
Institute at Texas A&M and the NHETC at Rutgers University respectively for hospitality
during the course of this work. We would also like to acknowledge the Aspen Center for
Physics and NSF grant 1066293 for a stimulating research environment
The efficacy of various machine learning models for multi-class classification of RNA-seq expression data
Late diagnosis and high costs are key factors that negatively impact the care
of cancer patients worldwide. Although the availability of biological markers
for the diagnosis of cancer type is increasing, costs and reliability of tests
currently present a barrier to the adoption of their routine use. There is a
pressing need for accurate methods that enable early diagnosis and cover a
broad range of cancers. The use of machine learning and RNA-seq expression
analysis has shown promise in the classification of cancer type. However,
research is inconclusive about which type of machine learning models are
optimal. The suitability of five algorithms were assessed for the
classification of 17 different cancer types. Each algorithm was fine-tuned and
trained on the full array of 18,015 genes per sample, for 4,221 samples (75 %
of the dataset). They were then tested with 1,408 samples (25 % of the dataset)
for which cancer types were withheld to determine the accuracy of prediction.
The results show that ensemble algorithms achieve 100% accuracy in the
classification of 14 out of 17 types of cancer. The clustering and
classification models, while faster than the ensembles, performed poorly due to
the high level of noise in the dataset. When the features were reduced to a
list of 20 genes, the ensemble algorithms maintained an accuracy above 95% as
opposed to the clustering and classification models.Comment: 12 pages, 4 figures, 3 tables, conference paper: Computing Conference
2019, published at
https://link.springer.com/chapter/10.1007/978-3-030-22871-2_6
Complex exon-intron marking by histone modifications is not determined solely by nucleosome distribution
It has recently been shown that nucleosome distribution, histone modifications and RNA polymerase II (Pol II) occupancy show preferential association with exons (“exon-intron marking”), linking chromatin structure and function to co-transcriptional splicing in a variety of eukaryotes. Previous ChIP-sequencing studies suggested that these marking patterns reflect the nucleosomal landscape. By analyzing ChIP-chip datasets across the human genome in three cell types, we have found that this marking system is far more complex than previously observed. We show here that a range of histone modifications and Pol II are preferentially associated with exons. However, there is noticeable cell-type specificity in the degree of exon marking by histone modifications and, surprisingly, this is also reflected in some histone modifications patterns showing biases towards introns. Exon-intron marking is laid down in the absence of transcription on silent genes, with some marking biases changing or becoming reversed for genes expressed at different levels. Furthermore, the relationship of this marking system with splicing is not simple, with only some histone modifications reflecting exon usage/inclusion, while others mirror patterns of exon exclusion. By examining nucleosomal distributions in all three cell types, we demonstrate that these histone modification patterns cannot solely be accounted for by differences in nucleosome levels between exons and introns. In addition, because of inherent differences between ChIP-chip array and ChIP-sequencing approaches, these platforms report different nucleosome distribution patterns across the human genome. Our findings confound existing views and point to active cellular mechanisms which dynamically regulate histone modification levels and account for exon-intron marking. We believe that these histone modification patterns provide links between chromatin accessibility, Pol II movement and co-transcriptional splicing
Collider signatures of goldstini in gauge mediation
We investigate the collider signatures of the multiple goldstini scenario in
the framework of gauge mediation. This class of models is characterized by a
visible sector (e.g. the MSSM or any extension) coupled by gauge interactions
to more than one SUSY breaking sector. The spectrum consists of a light
gravitino LSP, behaving as a goldstino, and a number of neutral fermions (the
pseudo-goldstini) with a mass between that of the LSP and that of the lightest
particle of the observable sector (LOSP). We consider the two situations where
the LOSP is either a gaugino-like neutralino or a stau and we assume only one
pseudo-goldstino of a mass of O(100) GeV. The coupling of the LOSP to the
pseudo-goldstino can be enhanced with respect to those of the gravitino giving
rise to characteristic signatures. We show that the decay modes of the LOSP
into a SM particle and a pseudo-goldstino can be significant. For both LOSP
scenarios we analyze (pseudo)-goldstini production at colliders. Compared to
standard gauge mediation the final state spectrum is softer and more
structured.Comment: v2: analysis of the stau LOSP scenario added, sections rearranged,
and Introduction and Conclusions rewritten to include the added scenario.
Version to appear in JHE
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