Cosmological constraints on R-parity violation from neutrino decay

If the neutrino mass is non-zero, as hinted by several experiments, then R-parity-violating supersymmetric Yukawa couplings can drive a heavy neutrino decay into lighter states. The heavy neutrino may either decay radiatively into a lighter neutrino, or it may decay into three light neutrinos through a Z-mediated penguin. For a given mass of the decaying neutrino, we calculate its lifetime for the various modes, each mode requiring certain pairs of R-parity-violating couplings be non-zero. We then check whether the calculated lifetimes fall in zones allowed or excluded by cosmological requirements. For the latter case, we derive stringent new constraints on the corresponding products of R-parity-violating couplings for given values of the decaying neutrino mass.Comment: 13 pages, Latex, uses axodraw.sty; version to appear in Physical Review

Recycling universe

If the effective cosmological constant is non-zero, our observable universe may enter a stage of exponential expansion. In such case, regions of it may tunnel back to the false vacuum of an inflaton scalar field, and inflation with a high expansion rate may resume in those regions. An ``ideal'' eternal observer would then witness an infinite succession of cycles from false vacuum to true, and back. Within each cycle, the entire history of a hot universe would be replayed. If there were several minima of the inflaton potential, our ideal observer would visit each one of these minima with a frequency which depends on the shape of the potential. We generalize the formalism of stochastic inflation to analyze the global structure of the universe when this `recycling' process is taken into account.Comment: 43 pages, 10 figure

How generic is cosmic string formation in SUSY GUTs

We study cosmic string formation within supersymmetric grand unified theories. We consider gauge groups having a rank between 4 and 8. We examine all possible spontaneous symmetry breaking patterns from the GUT down to the standard model gauge group. Assuming standard hybrid inflation, we select all the models which can solve the GUT monopole problem, lead to baryogenesis after inflation and are consistent with proton lifetime measurements. We conclude that in all acceptable spontaneous symmetry breaking schemes, cosmic string formation is unavoidable. The strings which form at the end of inflation have a mass which is proportional to the inflationary scale. Sometimes, a second network of strings form at a lower scale. Models based on gauge groups which have rank greater than 6 can lead to more than one inflationary era; they all end by cosmic string formation.Comment: 31 pages, Latex, submitted to PR

Inflation in Supersymmetric Unified Theories

We construct supersymmetric unified models which automatically lead to a period of inflation. The models all involve a U(1) symmetry which does not belong to the MSSM. We consider three different types of models depending on whether this extra U(1) is the subgroup of a non abelian gauge group, is a U(1) factor belonging to the visible sector or is a U(1) factor belonging to the hidden sector. Depending on the structure of the unified theory, on the spontaneous symmetry breaking pattern and on whether we have global or local supersymmetry, inflation may be driven by the non-vanishing vacuum expectation value of a F-term or by that of a D-term. In both scenarios cosmic strings form at the end of inflation, and they have different properties in each model. Both inflation and cosmic strings contribute to the CMBR temperature anisotropies. We show that the strings contribute to the $C_l$'s up to the level of 75 %. Hence the contribution from strings to the CMBR and to the density perturbations in the early Universe which lead to structure formation cannot be neglected. We also discuss a very interesting class of models which involve a $U(1)_{B-L}$ gauge symmetry.Comment: 22 pages, uses Revte

Supersymmetry without R-Parity and without Lepton Number

We investigate Supersymmetric models where neither R parity nor lepton number is imposed. Neutrino masses can be kept highly suppressed compared to the electroweak scale if the $\mu$-terms in the superpotential are aligned with the SUSY-breaking bilinear $B$-terms. This situation arises naturally in the framework of horizontal symmetries. The same symmetries suppress the trilinear R parity violating terms in the superpotential to an acceptable level.Comment: 18 pages, harvma

Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine

Despite rapid technical progress and demonstrable effectiveness for some types of diagnosis and therapy, much remains to be learned about clinical genome and exome sequencing (CGES) and its role within the practice of medicine. The Clinical Sequencing Exploratory Research (CSER) consortium includes 18 extramural research projects, one National Human Genome Research Institute (NHGRI) intramural project, and a coordinating center funded by the NHGRI and National Cancer Institute. The consortium is exploring analytic and clinical validity and utility, as well as the ethical, legal, and social implications of sequencing via multidisciplinary approaches; it has thus far recruited 5,577 participants across a spectrum of symptomatic and healthy children and adults by utilizing both germline and cancer sequencing. The CSER consortium is analyzing data and creating publically available procedures and tools related to participant preferences and consent, variant classification, disclosure and management of primary and secondary findings, health outcomes, and integration with electronic health records. Future research directions will refine measures of clinical utility of CGES in both germline and somatic testing, evaluate the use of CGES for screening in healthy individuals, explore the penetrance of pathogenic variants through extensive phenotyping, reduce discordances in public databases of genes and variants, examine social and ethnic disparities in the provision of genomics services, explore regulatory issues, and estimate the value and downstream costs of sequencing. The CSER consortium has established a shared community of research sites by using diverse approaches to pursue the evidence-based development of best practices in genomic medicine

Lawson criterion for ignition exceeded in an inertial fusion experiment

For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37 MJ of fusion for 1.92 MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion