1,170 research outputs found
Influence of Cu Diffusion Conditions on the Switching of Cu-SiO\u3csub\u3e2\u3c/sub\u3e-Based Resistive Memory Devices
This paper presents a study of Cu diffusion at various temperatures in thin SiO2 films. Film composition and diffusion products were analyzed using Secondary Ion Mass Spectroscopy, Rutherford Backscattering Spectrometry, X-ray Diffraction and Raman Spectroscopy methods. We found a strong dependence of the diffused Cu concentration, which varied between 0.8 at.% and 10-3 at.%, on the annealing temperature. X-ray diffraction and Raman studies revealed that Cu does not react with the SiO2 network and remains in elemental form after diffusion. Programmable Metallization Cell (PMC) resistive memory cells were fabricated with these Cu-diffused SiO2 films as the active elements and device performance is presented and discussed in the context of the materials characteristics
Theory of Current-Induced Magnetization Precession
We solve appropriate drift-diffusion and Landau-Lifshitz-Gilbert equations to
demonstrate that unpolarized current flow from a non-magnet into a ferromagnet
can produce a precession-type instability of the magnetization. The fundamental
origin of the instability is the difference in conductivity between majority
spins and minority spins in the ferromagnet. This leads to spin accumulation
and spin currents that carry angular momentum across the interface. The
component of this angular momentum perpendicular to the magnetization drives
precessional motion that is opposed by Gilbert damping. Neglecting magnetic
anisotropy and magnetostatics, our approximate analytic and exact numerical
solutions using realistic values for the material parameters show (for both
semi-infinite and thin film geometries) that a linear instability occurs when
both the current density and the excitation wave vector parallel to the
interface are neither too small nor too large. For many aspects of the problem,
the variation of the magnetization in the direction of the current flows makes
an important contribution.Comment: Submitted to Physical Review
Exploring Protein-Protein Interactions as Drug Targets for Anti-cancer Therapy with In Silico Workflows
We describe a computational protocol to aid the design of small molecule and peptide drugs that target protein-protein interactions, particularly for anti-cancer therapy. To achieve this goal, we explore multiple strategies, including finding binding hot spots, incorporating chemical similarity and bioactivity data, and sampling similar binding sites from homologous protein complexes. We demonstrate how to combine existing interdisciplinary resources with examples of semi-automated workflows. Finally, we discuss several major problems, including the occurrence of drug-resistant mutations, drug promiscuity, and the design of dual-effect inhibitors.Fil: Goncearenco, Alexander. National Institutes of Health; Estados UnidosFil: Li, Minghui. Soochow University; China. National Institutes of Health; Estados UnidosFil: Simonetti, Franco Lucio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Shoemaker, Benjamin A. National Institutes of Health; Estados UnidosFil: Panchenko, Anna R. National Institutes of Health; Estados Unido
Characterization and System Identification of XY Flexural Mechanism Using Double Parallelogram Manipulator for High Precision Scanning
This article represents modeling of double parallelogram flexural manipulator derived from basic classical mechanics theory. Fourth order vibration wave equation is used for mathematical modeling and its performance is determined for step input and sinusoidal forced input. Static characterization of DFM is carried out to determine stiffness and force deflection characteristics over the entire motion range and dynamic characteristics is carried out using Transient response and Frequency response. Transient response is determined using step input to DFM which gives system properties such as damping, rise time and settling time. These parameters are then compared with theoretical model presented previously. Frequency response of DFM system gives characteristics of system with different frequency inputs which is used for experimental modeling of DFM device. Here, Voice Coil Motor is used as Actuator and optical encoder is used for positioning sensing of motion stage. It is noted that theoretical model is having 5% accuracy with experimental results. To achieve better position and accuracy, PID and LQR (Linear Quadratic Regulator) implementation was carried out on experimental model. PID gains are optimally tuned by using Ziegler Nichols approach. PID control is implemented experimentally using dSPACE DS1104 microcontroller and Control Desk software. Experimentally, it is observed that positioning accuracy is less than 5 μm. Further multiple DFM blocks are arranged for developing XY flexural mechanism and static characterization was carried out on it. The comparison of experimental and FEA results for X-direction and Y-direction is presented at end of paper
Spin pumping and magnetization dynamics in metallic multilayers
We study the magnetization dynamics in thin ferromagnetic films and small
ferromagnetic particles in contact with paramagnetic conductors. A moving
magnetization vector causes \textquotedblleft pumping\textquotedblright of
spins into adjacent nonmagnetic layers. This spin transfer affects the
magnetization dynamics similar to the Landau-Lifshitz-Gilbert phenomenology.
The additional Gilbert damping is significant for small ferromagnets, when the
nonmagnetic layers efficiently relax the injected spins, but the effect is
reduced when a spin accumulation build-up in the normal metal opposes the spin
pumping. The damping enhancement is governed by (and, in turn, can be used to
measure) the mixing conductance or spin-torque parameter of the
ferromagnet--normal-metal interface. Our theoretical findings are confirmed by
agreement with recent experiments in a variety of multilayer systems.Comment: 10 pages, 6 figure
Enhanced Gilbert Damping in Thin Ferromagnetic Films
Using a scattering matrix approach, the precession of the magnetization of a
ferromagnet is shown to transfer spins into adjacent normal metal layers. This
``pumping'' of spins slows down the precession corresponding to an enhanced
Gilbert damping factor in the Landau-Lifshitz equation. The damping is
expressed in terms of the scattering matrix of the ferromagnet-normal metal
interface, which is accessible to model and first-principles calculations. Our
estimates for permalloy thin films explain the trends observed in recent
experiments.Comment: 1 figur
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Astrocytes refine cortical connectivity at dendritic spines
During cortical synaptic development, thalamic axons must establish synaptic connections despite the presence of the more abundant intracortical projections. How thalamocortical synapses are formed and maintained in this competitive environment is unknown. Here, we show that astrocyte-secreted protein hevin is required for normal thalamocortical synaptic connectivity in the mouse cortex. Absence of hevin results in a profound, long-lasting reduction in thalamocortical synapses accompanied by a transient increase in intracortical excitatory connections. Three-dimensional reconstructions of cortical neurons from serial section electron microscopy (ssEM) revealed that, during early postnatal development, dendritic spines often receive multiple excitatory inputs. Immuno-EM and confocal analyses revealed that majority of the spines with multiple excitatory contacts (SMECs) receive simultaneous thalamic and cortical inputs. Proportion of SMECs diminishes as the brain develops, but SMECs remain abundant in Hevin-null mice. These findings reveal that, through secretion of hevin, astrocytes control an important developmental synaptic refinement process at dendritic spines. DOI: http://dx.doi.org/10.7554/eLife.04047.00
Paraphrastic Reformulations in Spoken Corpora
International audienceOur work addresses the automatic detection of paraphrastic reformulation in French spoken corpora. The proposed approach is syn-tagmatic. It is based on specific markers and the specificities of the spoken language. Manual multi-dimensional annotation performed by two annotators provides fine-grained reference data. An automatic method is proposed in order to decide whether sentences contain or not paraphras-tic relations. The obtained results show up to 66.4% precision. Analysis of the manual annotations indicates that few paraphrastic segments show morphological modifications (inflection, derivation or compounding) and that the syntactic equivalence between the segments is seldom respected, as these usually belong to different syntactic categories
Liquid 4He near the superfluid transition in the presence of a heat current and gravity
The effects of a heat current and gravity in liquid 4He near the superfluid
transition are investigated for temperatures above and below T_lambda. We
present a renormalization-group calculation based on model F for the Green's
function in a self-consistent approximation which in quantum many-particle
theory is known as the Hartree approximation. The approach can handle a zero
average order parameter above and below T_lambda and includes effects of
vortices. We calculate the thermal conductivity and the specific heat for all
temperatures T and heat currents Q in the critical regime. Furthermore, we
calculate the temperature profile. Below T_lambda we find a second correlation
length which describes the dephasing of the order parameter field due to
vortices. We find dissipation and mutual friction of the superfluid-normal
fluid counterflow and calculate the Gorter-Mellink coefficient A. We compare
our theoretical results with recent experiments.Comment: 26 pages, 9 figure
Loss of PRDM1/BLIMP-1 function contributes to poor prognosis of activated B-cell-like diffuse large B-cell lymphoma
PRDM1/BLIMP-1, a master regulator of plasma-cell differentiation, is frequently inactivated in activated B-cell-like (ABC) diffuse large B-cell lymphoma (DLBCL) patients. Little is known about its genetic aberrations and relevant clinical implications. A large series of patients with de novo DLBCL was effectively evaluated for PRDM1/BLIMP-1 deletion, mutation, and protein expression. BLIMP-1 expression was frequently associated with the ABC phenotype and plasmablastic morphologic subtype of DLBCL, yet 63% of the ABC-DLBCL patients were negative for BLIMP-1 protein expression. In these patients, loss of BLIMP-1 was associated with Myc overexpression and decreased expression of p53 pathway molecules. In addition, homozygous PRDM1 deletions and PRDM1 mutations within exons 1 and 2, which encode for domains crucial for transcriptional repression, were found to show a poor prognostic impact in patients with ABC-DLBCL but not in those with germinal center B-cell-like DLBCL (GCB-DLBCL). Gene expression profiling revealed that loss of PRDM1/BLIMP-1 expression correlated with a decreased plasma-cell differentiation signature and upregulation of genes involved in B-cell receptor signaling and tumor-cell proliferation. In conclusion, these results provide novel clinical and biological insight into the tumor-suppressive role of PRDM1/BLIMP-1 in ABC-DLBCL patients and suggest that loss of PRDM1/BLIMP-1 function contributes to the overall poor prognosis of ABC-DLBCL patients
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