3,4,7,8-diepoksibisiklo[4.3.0]nonan’ın yeni bir yaklaşımla etkin ve seçici sentezi

06.03.2018 tarihli ve 30352 sayılı Resmi Gazetede yayımlanan “Yükseköğretim Kanunu İle Bazı Kanun Ve Kanun Hükmünde Kararnamelerde Değişiklik Yapılması Hakkında Kanun” ile 18.06.2018 tarihli “Lisansüstü Tezlerin Elektronik Ortamda Toplanması, Düzenlenmesi ve Erişime Açılmasına İlişkin Yönerge” gereğince tam metin erişime açılmıştır.3a,4,7,7a-tetrahidro-1H-inden (THI)'in (1) CH3COOH (asetik asit) içerisinde 3 ekivalent N-bromsüksinimit (NBS), LiClO4 (lityum perklorat) kullanılarak oda sıcaklığında brominasyonu dibromdiasetatlı (62 ve 63) ürünler ile sonuçlandı. (1R,2R,5R,6R)-1,6-dibromoktahidro-1H-inden-2,5-diasetat (62) ve (1R,2R,5S,6S)-1,6-dibromoktahidro-1H-inden-2,5- diasetat (63) ürünleri kolon kromatografisi ile izole edildi. Dibromdiasetatlar organik çözücüler içerisinde bazlarla etkileştirilerek diepoksite (61) dönüştürüldü. (1R,2R,5R,6R)-1,6-dibromoktahidro-1H-inden-2,5-diasetat (62) ve (1R,2R,5S,6S)-1,6-dibromoktahidro-1H-inden-2,5- diasetat (63) ürün karışımından 3,4,7,8-diepoksibisiklo[4.3.0]nonan (61) maddesi elde edildi. Bütün ürünlerin reaksiyon mekanizmaları detaylı bir şekilde tartışıldı. Tüm bileşikler spektral verilerle ve kimyasal dönüşümlerle karakterize edildi.3a,4,7,7-tetrahydro-1H-indene (THI) (1), in CH3COOH (acetic acid), 3 equivalents of N- bromo succinimide (NBS), LiClO4 (lithium perchlorate) at room temperature using bromination dibromo diacetate the (62 and 63) of the product resulted in. 1,6-dibromo octahydro-1H-indene-2,5-diacetate (62) and (1R,2R,5S,6S)-1,6-dibromooctahydro-1H-indene-2,5- diacetate (62) product was isolated by column chromatography. Dibromo diacetate products in organic solvents by reacting diepoxide (61) was converted with bases. 1,6-dibromo octahydro-1H-indene-2,5-diacetate (62) and (1R,2R,5S,6S)-1,6-dibromooctahydro-1H-indene-2,5-diacetate (63) of a mixture of the product was obtained 3,4,7,8-diepoxy bicyclo [4.3.0] nonane (61). Reaction mechanism of all items were discussed in detail. All compounds were characterized by spectral data and the chemical conversion

Bodıpy içerikli ninhidrin türevlerinin sentezi, fotofiziksel ve elektrokimyasal özellikleri

06.03.2018 tarihli ve 30352 sayılı Resmi Gazetede yayımlanan “Yükseköğretim Kanunu İle Bazı Kanun Ve Kanun Hükmünde Kararnamelerde Değişiklik Yapılması Hakkında Kanun” ile 18.06.2018 tarihli “Lisansüstü Tezlerin Elektronik Ortamda Toplanması, Düzenlenmesi ve Erişime Açılmasına İlişkin Yönerge” gereğince tam metin erişime açılmıştır.Tez çalışması kapsamında parmak izi belirlemede kullanılan ninhidrin 183 bileşiği ile floresans özelliğe sahip BODIPY türevlerinin kenetlenerek floresans özelliği daha iyi olan yeni bileşiklerin sentezlenmesi amaçlanmıştır. Bu amaçla ninhidrin çekirdeği ile BODIPY çekirdeği kenetlenerek yeni bileşikler sentezlenmiştir. Bileşiklerin spektroskopik ölçümleri, yapı analizleri, fotofiziksel ve elektrokimyasal özellikleri incelenmiştir. Böylece kirli ve pürüzlü yüzeylerdeki gizli parmak izlerinin tespitinde önemli sorunları çözmesi muhtemel yüksek floresans özellikli yeni bileşikler hazırlanmıştır. Bu bileşiklerin kriminal araştırmalarda kolaylıklar sağlayabilecek potansiyelde olması ve bunların ekonomiye kazandırılması halinde ülke ekonomisine önemli katkılar sağlayacağı düşünülmektedir.Within the scope of the thesis study, it was aimed to synthesize new compounds with better fluorescence properties by binding ninhydrin 183 compound and fluorescence specific BODIPY derivatives for fingerprint identification. In this work, new compounds were synthesized by coupling ninhydrin core with BODIPY core. Spectroscopic, structural, photophysical and electrochemical properties of compounds were investigated. Thus, new compounds with high fluorescence properties have been prepared that are likely to solve important problems in detecting hidden fingerprints on dirty and rough surfaces. It is thought that these compounds are potentially capable of providing convenience in criminal investigations and that they will provide significant contributions to the country's economy if they are earned

A study of participation motives in sports, loneliness and depression levels of children with specific learning disabilities in terms of some variables

This study aims to examine the sport participation motivation, loneliness and depression levels of students with specific learning disabilities in terms of some variables. Screening model used in the study. The research group is constituted by 85 students who had been diagnosed with Specific Learning disabilities in Special Education and Rehabilitation Centers in Kocaeli province. Personal information form prepared by the researchers and developed by Gill, Gross and Huddleston (1983), and the Turkish validity and reliability study was made by Oyar, Aşçı, Çelebi and Mülazımoğlu (2001)."Sport Participation Motivation Scale", developed by Kovacs (1980) and the validity and reliability of the Turkish version was made by Öy (1991). "Depression Scale for Children" and developed Ashler ve Wheller (1985) and the validity and reliability of the Turkish version was made by Kaya (2005) "Loneliness Scale for Children” were used as the data collection tools.  The sports participation motives, depression and loneliness levels of the participants have been evaluated in terms of age, gender, natural / adoptive parents, family's economic status, father's occupational status, number of people in the family, number of siblings, family attitude and the state of doing sport. In the evaluation of the research data, descriptive statistics, t-test, ANOVA test and correlation analysis were used. In the findings, sports participation motives of participants were significantly differ according to the gender, family attitudes and the status of doing sports. Also according to the age, in loneliness level, and according to the number of siblings in the levels of loneliness and depression, significant differences were found. As a result of the correlation, a positive relationship between depression and loneliness status of the participants was found. Thus, in children at the 9-14 age range with specific learning disability it was concluded that the family attitude, number of siblings and to do sports have an impact in a positive way on the loneliness, depression and sports participation

Evaluation of total oxidant status, total antioxidant capacity and oxidative stress levels in humor aqueous of diabetic cataract patients

Purpose: Diabetic retinopathy (DRP) is one of the most common complications of diabetes mellitus and various studies have demonstrated the role of increased oxidative stress due to hyperglycemia in its pathophysiology. There are few studies in the literature examining total antioxidant capacity (TAC) and total oxidant status (TOS) in humor aqueous, and we were unable to find any, which measured oxidative stress index (OSI). The aim of this study was to investigate whether TAC, TOS, and OSI in the aqueous humor changed according to DRP stage. Materials and Methods: This prospective study included a total of 86 cataract patients: 31 healthy patients with senile cataract (Group 1), 19 diabetic patients without DRP (Group 2), 17 patients with nonproliferative DRP (Group 3), and 19 patients with proliferative DRP (Group 4). Aqueous humor samples were obtained prior to cataract surgery. TAC, TOS, and OSI levels were measured spectrophotometrically and compared between the groups. Results: The analysis of TAC levels revealed that TAC levels were significantly higher in the control group (Group 1) compared to DRP patients (Group 3 and 4, p=0.042 and p=0.02, respectively), while TOS and OSI levels were lower in Group 1 compared to all diabetic groups (Group 2, 3, and 4) (p<0.05). Conclusion: The findings of increased TOS and OSI and decreased TAC levels in diabetic patients support the belief that oxidative stress might be an important etiologic factor in DRP. Increased oxidative stress may be a potential therapeutic target in the prevention and management of DRP. © 2020 Gazi Eye Foundation. All rights reserved

Dirençli granülomatöz polianjiitis olgusu

Vaskülitler, kan damarlarının inflamatuvardestrüksiyonu ile karakterize heterojen bir grup hastalıktır. Vaskülitler tutulan damar özelliğine göre klinik bulgu verebilir. Primer vaskülitler damar tutulum özelliklerine göre büyük, orta ve küçük damar vasküliti olarak ayrılır. Granülomatöz polianjiitis GPA ANCA ilişkili küçük damar vaskülitidir. GPA sınırlı ve sistemik tutulumla seyredebilir. Bu olgu, akciğer tutulumu olan sistemik ve sınırlı GPA olgularında tedavive yan etkileri paylaşmak için sunulmuştu

Boya çiçeği (Neotchihatchewia isatidea) bitkisindeki vitaminler ile glutatyon miktarlarının araştırılması

Bu çalışmada, paleoendemik olan boya çiçeği (Neotchihatchewia İsatidea) bitkisinin yaprak ve çiçeklerinde; indirgenmiş glutatyon (GSH), yükseltgenmiş glutatyon (GSSG) ile A vitamini, E vitamini, β-karoten, C vitamini, tiamin klorür (B1 vitamini), riboflavin (B2 vitamini), nikotinik asit (B3 vitamini), pridoksin klorür (B6 vitamini) ve folik asit (B9 vitamini) vitaminlerinin miktarları Yüksek Performanslı Sıvı Kromatografisi (HPLC) ile belirlendi. Boya çiçeği bitkisinin yapraklarındaki GSH, GSSG, A, E, β-karoten, C vitamini, B1, B2, B3, B6 ve B9 vitaminlerinin miktarları sırası ile 1867,82±50,95 g/g; 306,77±19,81 g/g; 0,59±0,09 g/g; 0,46±0,08 g/g; 2,13±0,55 g/g; 282,86±9,24 g/g; 98,91±11,68 g/g; 20,19±3,44 g/g; 24,28±3,15 g/g; 97,21±11,68 g/g; 7,28±1,80 g/g olduğu gözlendi. Aynı bitkinin çiçeklerindeki GSH, GSSG, A, E, β-karoten, likopen, C vitamini, B1, B2, B3, B6 ve B9 vitaminlerinin miktarlarının sırası ile 2010,93±25,01 g/g; 474,64±30,64 g/g; 1,75±0,39 g/g; 3,96±0,41 g/g; 14,67±2,09 g/g; 0,42±0.08 g/g; 194,72±8,09 g/g; 52,30±6,38 g/g; 10,54±2,05 g/g; 27,64±4,48 g/g; 98,91±10,18 g/g; 10,37±3,17 g/g olduğu tespit edildi. Elde edilen bu verilerden, bu bitkinin yaprak ve çiçeklerinin GSH, C vitamini, B1 ve B6 vitaminleri açısından iyi bir kaynak olduğu söylenebilir.In this study, the amounts of reduced form glutathione (GSH), oxidized form glutathione (GSSG) and vitamin A, vitamin E, Beta-carotene, vitamin C, thiamine hydrochloride (vitamin B1), riboflavin (vitamin B2), nicotinic acid (vitamin B3), pyridoxine hydrochloride (vitamin B6) and folic acid (vitamin B9) in leaf and flowers of which have been endemic Neotchihatchewia İsatidea sample were determined by using High Performance Liquid Chromatography. The amount of GSH, GSSG and vitamin A, vitamin E, β-carotene, vitamin C, vitamin B1, vitamin B2, vitamin B3, vitamin B6 and vitamin B9 in leafs of Neotchihatchewia İsatidea were obtained to be 1867,82±50,95 g/g; 306,77±19,81 g/g; 0,59±0,09 g/g; 0,46±0,08 g/g; 2,13±0,55 g/g; 282,86±9,24 g/g; 98,91±11,68 g/g; 20,19±3,44 g/g; 24,28±3,15 g/g; 97,21±11,68 g/g; 7,28±1,80 g/g respectively. The amount of GSH, GSSG and vitamin A, vitamin E, β-carotene, lycopene, vitamin C, vitamin B1, vitamin B2, vitamin B3, vitamin B6 and vitamin B9 in flowers of same plants 2010,93±25,01 g/g; 474,64±30,64 g/g; 1,75±0,39 g/g; 3,96±0,41 g/g; 14,67±2,09 g/g; 0,42±0.08 g/g; 194,72±8,09 g/g; 52,30±6,38 g/g; 10,54±2,05 g/g; 27,64±4,48 g/g; 98,91±10,18 g/g; 10,37±3,17 g/g respectively. It may be concluded from the results that, the flowers and leavies of this plant (Neotchihatchewia İsatidea) reaches in terms of amount of GSH, vitamin C, vitamin B1 and vitamin B6

THE EFFECT OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH SPONTANEOUS SPONDYLODISCITIS

Objective: Spontaneous spondylodiscitis is a rare but serious infectious disease of the vertebral column that can lead to permanent neurological deficits. We investigated the differences during follow-up of this pathology, which is more common in patients undergoing hemodialysis (HD) treatment for chronic kidney disease (CKD), compared with the general population. Materials and Methods: The data of patients who were treated for spontaneous spondylodiscitis between 2016-2021 at the Başkent University Department of Neurosurgery were used retrospectively. The patients were divided into 2 groups according to the diagnosis of CKD. Demographic data of the patients, biochemical values at the time of diagnosis (C-reactive protein, sedimentation, leukocyte, lymphocyte), microbiological and pathological examination results, and treatment method (surgical, medical) applied after diagnosis was obtained from the medical records. The effects of CKD presence and treatment methods on patient survival were investigated. Results: Of the 49 patients included in the study, 57.1% were female and the mean age was 66 years. Twenty-four of the patients were chronic HD patients. The microbiological examination of the samples taken determined that the causative pathogen could be produced in the cultures of 21 (42.8%) patients. According to the results of the pathological examination, signs of infection were detected in 24 (48.9%) patients. It was determined that 27 of the patients were operated. There was a central venous catheter in 20 of the patients. There was no statistically significant difference in survival between the groups that were operated on for instability and those that were not operated on. However, chronic renal failure and the presence of central venous catheters increased mortality statistically significantly. Conclusion: In the presence of back pain in chronic HD patients, spondylodiscitis should be suspected and diagnosed at an early stage, even if there is no fever or high infection parameters. Finally, great emphasis on disinfection procedures and aseptic techniques in patients with central venous catheters protected from these serious infectious complications