114 research outputs found
Asymmetric Fermion Superfluid with Inter- and Intra-Species Pairings
We investigate the phase structure of an asymmetric fermion superfluid with
inter- and intra-species pairings. The introduction of the intra-species
pairing mechanism in canonical ensemble changes significantly the phase diagram
and brings in a new state with coexisting inter- and intra-species pairings.
Different from the case with only inter-species pairing, all the fermion
excitations are fully gapped in the region with intra-species pairing.Comment: 5 pages, 4 figure
Comparison of the Immunoregulatory Function of Different Constituents in Radix Astragali and Radix Hedysari
Radix Astragali (RA), known as “Huangqi” in China, is one of the most popular herbal medicines known worldwide to reinforce “Qi”. RA is traditionally prepared from the dried roots of Astragalus membranaceus (MJHQ) and A. membranaceus var. mongholicus (MGHQ). Radix Hedysari is named “Hongqi” (HQ), which is similar to RA. We assessed and compared the chemical constituents and bioactivity of RA and HQ. Different constituents were extracted into five major parts and were analyzed using different methods. Comparison of the immunological effects of extracts was done by using two immunological models. Results showed that flavonoids and saponins present in RA and HQ were not only structurally significantly different but also different in their immunological effect. Amino acids extract (AE) in MGHQ shows immunological effect while AE in MJHQ and HQ did not. Polysaccharides comprised the major constituents in RA and HQ. All polysaccharides extract (PE) of the three herbs showed similar levels of immunological effect in both immunological assays
UroVysion™ fluorescence in situ hybridization (FISH) possibly has a high positive rate in carcinoma of non-urothelial lineages
Background: Positive UroVysion™ fluorescence in situ hybridization (FISH) is generally considered as urothelial carcinoma (UC). We clarify if UroVysion™ FISH can be positive in carcinoma of non-urothelial lineages (CNUL), and verify the consistency of urine FISH and histological FISH in CNUL.Methods: All CNUL subjects detected by urine FISH assay due to haematuria from Tongji Hospital were screened. Meanwhile, 2 glandular cystitis and 2 urothelial carcinoma were served as negative or positive control. Paraffin-embedded tissue sections of all subjects were sent to the pathology department for histological FISH detection.Results: A total of 27 patients were included in this study, including 9 with adenocarcinomas, 11 with squamous cell carcinomas, and 7 with other tumour types. The overall positive rate in urine FISH was 64.00% (16/25) in patients with CNUL, 77.78% (7/9) in those with adenocarcinoma and 54.55% (6/11) in those with squamous carcinoma. There was a significant difference in the GLP p16 gene deletion rate between UC and CNUL (100% vs. 8.00%, p = 0.017). Histological FISH results showed that the histological results of 19 patients were consistent with their urine FISH results, and only one patient with stage Ⅲa urachal carcinoma had inconsistent histological FISH results (positive) and urine FISH (negative) results.Conclusion: We demonstrated for the first time the application value of FISH in CNUL on urine samples. Positive urine FISH tests indicate not only UC, but also CNUL. UroVysion™ FISH possibly has a high positive rate in CNUL. CNUL and UC have different genetic changes shown by FISH
ESMC: Entire Space Multi-Task Model for Post-Click Conversion Rate via Parameter Constraint
Large-scale online recommender system spreads all over the Internet being in
charge of two basic tasks: Click-Through Rate (CTR) and Post-Click Conversion
Rate (CVR) estimations. However, traditional CVR estimators suffer from
well-known Sample Selection Bias and Data Sparsity issues. Entire space models
were proposed to address the two issues via tracing the decision-making path of
"exposure_click_purchase". Further, some researchers observed that there are
purchase-related behaviors between click and purchase, which can better draw
the user's decision-making intention and improve the recommendation
performance. Thus, the decision-making path has been extended to
"exposure_click_in-shop action_purchase" and can be modeled with conditional
probability approach. Nevertheless, we observe that the chain rule of
conditional probability does not always hold. We report Probability Space
Confusion (PSC) issue and give a derivation of difference between ground-truth
and estimation mathematically. We propose a novel Entire Space Multi-Task Model
for Post-Click Conversion Rate via Parameter Constraint (ESMC) and two
alternatives: Entire Space Multi-Task Model with Siamese Network (ESMS) and
Entire Space Multi-Task Model in Global Domain (ESMG) to address the PSC issue.
Specifically, we handle "exposure_click_in-shop action" and "in-shop
action_purchase" separately in the light of characteristics of in-shop action.
The first path is still treated with conditional probability while the second
one is treated with parameter constraint strategy. Experiments on both offline
and online environments in a large-scale recommendation system illustrate the
superiority of our proposed methods over state-of-the-art models. The
real-world datasets will be released
GW26-e2244 Gene Mutations in Chinese with Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy-a cohort registry study
Impact of fish consumption on all-cause mortality in older people with and without dementia: a community-based cohort study
BACKGROUND
Increased fish consumption reduces the risk of dementia. However, it is unknown whether fish consumption reduced all-cause mortality in people with dementia. The purpose of the study is to investigate the association of fish consumption with all-cause mortality in older people with dementia versus those without dementia.
METHODS
Using a standard method of the Geriatric Mental State, we interviewed 4165 participants aged ≥ 60 years who were randomly recruited from five provinces in China during 2007-2009 to collect the baseline data of socio-demography, disease risk factors, histories of disease, and details of dietary intakes, and diagnosed dementia (n = 406). They were followed up for vital status until 2012.
RESULTS
The cohort follow-up documented 329 deaths; 61 were in participants with dementia (55.3 per 1000 person-years) and 224 were those without dementia (22.3). In all participants, the risk of all-cause mortality was reduced with fish intake at " ≥ twice a week" (multivariate-adjusted hazard ratio 0.58, 95% CI 0.34-0.96) and at "once a week or less" (0.79, 0.53-1.18) compared to "never eat" over the past two years. In participants without baseline dementia, the corresponding HRs for all-cause mortality were 0.57 (0.33-0.98) and 0.85 (0.55-1.31), while in participants with dementia were 1.36 (0.28-6.60) and 1.05 (0.30-3.66), respectively.
CONCLUSION
This study reveals that consumption of fish in older age reduced all-cause mortality in older people without dementia, but not in people with dementia. Fish intake should be increased in older people in general, prior to the development of dementia in the hope of preventing dementia and prolonging life
On methods for assessment of the influence and impact of observations in convection-permitting numerical weather prediction
In numerical weather prediction (NWP), a large number of observations are
used to create initial conditions for weather forecasting through a process
known as data assimilation. An assessment of the value of these observations
for NWP can guide us in the design of future observation networks, help us to
identify problems with the assimilation system, and allow us to assess changes
to the assimilation system. However, the assessment can be challenging in
convection-permitting NWP. First, the strong nonlinearity in the forecast model
limits the methods available for the assessment. Second, convection-permitting
NWP typically uses a limited area model and provides short forecasts, giving
problems with verification and our ability to gather sufficient statistics.
Third, convection-permitting NWP often makes use of novel observations, which
can be difficult to simulate in an observing system simulation experiment
(OSSE). We compare methods that can be used to assess the value of observations
in convection-permitting NWP and discuss operational considerations when using
these methods. We focus on their applicability to ensemble forecasting systems,
as these systems are becoming increasingly dominant for convection-permitting
NWP. We also identify several future research directions: comparison of
forecast validation using analyses and observations, the effect of ensemble
size on assessing the value of observations, flow-dependent covariance
localization, and generation and validation of the nature run in an OSSE.Comment: 35 page
Mechanistic insights into NO-H2 reaction over Pt/boron-doped graphene catalyst
This work presents a systematical experimental and density functional theory (DFT) studies to reveal the mechanism of NO reduction by H 2 reaction over platinum nanoparticles (NPs) deposited on boron-doped graphene (denoted as Pt/BG) catalyst. Both characterizations and DFT calculations identified boron (in Pt/BG) as an additional NO adsorption site other than the widely recognized Pt NPs. Moreover, BG led to a decrease of Pt NPs size in Pt/BG, which facilitated hydrogen spillover. The mathematical and physical criteria of the Langmuir-Hinshelwood dual-site kinetic model over the Pt/BG were satisfied, indicating that adsorbed NO on boron (in Pt/BG) was further activated by H-spillover. On the other hand, Pt/graphene (Pt/Gr) demonstrated a typical Langmuir-Hinshelwood single-site mechanism where Pt NPs solely served as active sites for NO adsorption. This work helps understand NO-H 2 reaction over Pt/BG and Pt/Gr catalysts in a closely mechanistic view and provides new insights into roles of active sites for improving the design of catalysts for NO abatement
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