Vaccaria hypaphorine alleviates lipopolysaccharide-induced inflammation via inactivation of NFκB and ERK pathways in Raw 264.7 cells

10.1186/s12906-017-1635-1BMC Complementary and Alternative Medicine17112

Spatiotemporal evolution characteristics and the driving force of habitat quality in the Qinghai–Tibet Plateau in topographic view (2000–2020)

IntroductionAs a key indicator to evaluate biodiversity and eco-function, habitat quality shows the value of ecosystem services. The Qinghai–Tibet Plateau occupies the highest elevation in the global dimension, where the regional environment is greatly affected by multiple factors including the terrain comprehensively.MethodsIn the present study, the InVEST model was employed to assess the habitat quality across varying terrain gradients. The study observed the displacement of the center of gravity of habitat quality under different topographical factors over the past 20 years to learn the trend of changes. Additionally, the Geo-detector model was enhanced to explore the contribution rate of driving factors including biodiversity in different topographic positions and overall.ResultsThe results found the following: (1) The habitat quality of the Qinghai–Tibet Plateau was positively correlated with the terrain gradient, and the mean values of habitat quality increased with the gradual increase in terrain gradient. In the period between 2000 and 2020, mean habitat quality values within the study area exhibited a slight fluctuating trend with the spatial distribution characterized by higher values in the southeast and lower values in the northwest. (2) Among different terrain gradients, trends in the mean center’s shift of habitat quality were diverse. The mean center of gradient I went north but gradient V went west. The mean center of the habitat quality in gradients II–IV showed an uncertain trend. (3) The NDVI exerted the most vital influence on the quality of habitats irrespective of different terrain gradients. Annual mean temperature, soil type, and slope occupied two to four places in each terrain.DiscussionThe study indicates that in the last two decades, the habitat quality on the Qinghai–Tibet Plateau has gradually increased across different terrain locations. In terms of policies to protect habitats, terrain should be classified and targeted accordingly

Snowflake-Shaped ZnO Nanostructures-Based Gas Sensor for Sensitive Detection of Volatile Organic Compounds

Volatile organic compounds (VOCs) have been considered severe risks to human health. Gas sensors for the sensitive detection of VOCs are highly required. However, the preparation of gas-sensing materials with a high gas diffusion performance remains a great challenge. Here, through a simple hydrothermal method accompanied with a subsequent thermal treatment, a special porous snowflake-shaped ZnO nanostructure was presented for sensitive detection of VOCs including diethyl ether, methylbenzene, and ethanol. The fabricated gas sensors exhibit a good sensing performance including high responses to VOCs and a short response/recovery time. The responses of the ZnO-based gas sensor to 100 ppm ethanol, methylbenzene, and diethyl ether are about 27, 21, and 11, respectively, while the response times to diethyl ether and methylbenzene are less than 10 seconds. The gas adsorption-desorption kinetics is also investigated, which shows that the gas-sensing behaviors to different target gases are remarkably different, making it possible for target recognition in practical applications

Comparative efficacy of olaparib in combination with or without novel antiandrogens for treating metastatic castration-resistant prostate cancer

BackgroundStudies using novel antiandrogens (NAA) in patients with metastatic castration-resistant prostate cancer (mCRPC) have shown overall survival benefit. As patients develop resistance to NAA therapy, the poly(ADP-ribose) polymerase inhibitor (PARPi) olaparib in combination with NAA may become a promising therapy. However the overall benefit of olaparib monotherapy or combination therapy still needs to be evaluated. Therefore, we performed a network meta-analysis to assess the efficacy and toxicity between olaparib, olaparib combined with abiraterone and NAA.MethodsWe searched PubMed, EMBASE, the Cochrane Library and American Society of Clinical Oncology (ASCO) University Meeting abstracts for randomized controlled trials reporting olaparib and NAA from 2010 up to March, 2023. Network meta-analysis using Stata 16.0 and R 4.4.2, hazard ratios (HR) with 95% confidence intervals (CI) were used to assess the results.ResultsFour trials reported olaparib, olaparib plus abiraterone and apalutamide plus abiraterone. radiographic progression-free survival (rPFS) was significantly lower in patients on apalutamide plus abiraterone compared to olaparib (HR, 1.43; 95% CI, 1.06-1.93). rPFS was similar for olaparib plus abiraterone and olaparib (HR, 1.35; 95% CI, 0.99-1.84); likewise, olaparib plus abiraterone and apalutamide plus abiraterone were similar (HR, 1.06; 95% CI, 0.83-1.35). In addition, there was no significant difference between the three interventions for OS. But olaparib has the highest probability of being a preferred treatment for improving rPFS and OS.ConclusionrPFS was in favor of olaparib compared with apalutamide plus abiraterone. But there were no difference between olaparib plus abiraterone and either olaparib or apalutamide plus abiraterone. Apalutamide plus abiraterone might be the most preferred intervention in cases where AEs are involved.Systematic review registrationhttps://inplasy.com, identifier INPLASY2023100072

mapDATAge: a ShinyR package to chart ancient DNA data through space and time

<p>The mapDATAge package is designed to explore the presence of geographic and temporal patterns in ancient DNA data. It takes simple tabulated text files as input and contains different panels to draw a number of maps and plots that are common to most ancient DNA studies, including drawing: (1) the spatial and temporal distributions of a given set of samples (SMAP) or alleles (AMAP); (2) temporal allelic trajectories (TRAJECTORY); (3) maps of individual ancestry profiles on a map (ANCESTRY); (4) PCA (or MDS) and map related maps of spatio-temporal distributions (PCA); (5) spatio-temporal distributions of alleles at one or multiple loci (MULTIPLESNPS); (6) maps of (sub-)haplogroups (HAPLO), and; (7) finally, options are provided to automatically generate figures, following the selection of a preselected range of temporal and spatial and temporal parameters, which can be useful to contrast data from different loci and/or species (ONECLICK).</p&gt

DNA methylation-based profiling of horse archaeological remains for age-at-death and castration

<p>Age profiling of archaeological bone assemblages can inform on past animal management practices, but is limited by the fragmentary nature of the fossil record and the lack of universal skeletal markers for age. DNA methylation clocks offer new, albeit challenging, alternatives for estimating the age-at-death of ancient individuals. Here, we take advantage of the availability of a DNA methylation clock based on 31,836 CpG sites and dental age markers in horses to assess age predictions in 84 ancient remains. We evaluate our approach using whole-genome sequencing data and develop a capture assay providing reliable estimates for only a fraction of the cost. We also leverage DNA methylation patterns to assess castration practice in the past. Our work opens for a deeper characterization of past husbandry and ritual practices and holds the potential to reveal age mortality profiles in ancient societies, once extended to human remains.</p&gt

Early dispersal of domestic horses into the Great Plains and northern Rockies

<p>The horse is central to many Indigenous cultures across the American Southwest and the Great Plains. However, when and how horses were first integrated into Indigenous lifeways remain contentious, with extant models derived largely from colonial records. We conducted an interdisciplinary study of an assemblage of historic archaeological horse remains, integrating genomic, isotopic, radiocarbon, and paleopathological evidence. Archaeological and modern North American horses show strong Iberian genetic affinities, with later influx from British sources, but no Viking proximity. Horses rapidly spread from the south into the northern Rockies and central plains by the first half of the 17th century CE, likely through Indigenous exchange networks. They were deeply integrated into Indigenous societies before the arrival of 18th-century European observers, as reflected in herd management, ceremonial practices, and culture</p&gt