179 research outputs found

    Japanese Linguistic Politeness as Speakers’ Rational Choice and Social Strategy

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    Japanese linguistic politeness is a commonly observed phenomenon and the speaker’s being linguistically polite is an expected social behavior in the Japanese society. Most previous studies of Japanese politeness describe such a polite social behavioral pattern at a superficial or observational level without exploring the linguistic nature of such a polite behavior or the speaker’s motivations for performing a polite speech act in a particular speech context. From some linguistic, sociolinguistic, psycholinguistic and sociological perspectives, this study defines “politeness” as the speaker’s rational choices and a social strategy in the Japanese culture beyond surface language forms themselves. This paper claims that so-called “polite” or “honorific” language forms as commonly employed by the speaker in various social interactions do not necessarily always indicate that such a speaker must be a polite person. The so-called “polite” language is “linguistic” in nature and is thus more about a particular language form itself than about the speaker himself/herself. This paper further claims that the speaker makes rational choices of particular polite language forms to realize his/her communicative intention with the outcomes as perceived. Thus, this study explores the relationship between polite language forms and their social, cultural, and pragmatic functions. It concludes that speakers in the same speech community are conscious of linguistic choices which conform to their normative views for the interaction types; there is no simple equation between polite forms and polite speakers, and speakers are rational actors in making linguistic choices

    Japanese Adjective Conjugation Patterns and Sources of Difficulty in Foreign Language Learning

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    This paper is a study of the complexity of Japanese adjective conjugations in relation to sources of foreign language learning difficulty. It focuses on two types of adjectives: i-adjectives and na-adjectives and their conjugation patterns, including their respective morphological requirements for particular grammatical functions. This study regards knowledge of Japanese adjective conjugations as one of the levels of abstract lexical structure: morphological realization patterns. To explore sources of learner errors in producing Japanese adjective conjugations, the speech performance data are from two groups of adult speakers of American English learning Japanese as a foreign language. This study makes two claims: Any successful acquisition of a foreign language must involve the complete acquisition of not only foreign language lexical items but also its morphological realization patterns, and any successful foreign language learner must be able to use language-specific morphological realization patterns as surface devices in speech production. This study offers some pedagogical suggestions for successful acquisition of Japanese adjective conjugation patterns

    The Light Verb “Suru” in Japanese Lexical-Conceptual Structure and Sources of Leaning Difficulty

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    As frequently observed in second or foreign language learning, the Japanese light verb “suru” may course much learning difficulty. Most previous studies focused on the surface description of “suru” in terms of its role in some particular Japanese lexical structure or verbal formation in a particular syntactic environment. This paper assumes that the light verb “suru” drives certain particular Japanese lexical-conceptual structure, and language-specific lexicalization patterns must be learned as such. It offers a linguistic analysis of the sources of the light verb “suru” in structuring particular verbalization patterns and relates this analysis to potential sources of learning difficulty in second or foreign language learning. Instances of cross-linguistic influence or learner errors in learning the Japanese lexical-conceptual structure driven by “suru” are from some early stage American students learning Japanese as a foreign language. This paper implicates a lexicon-driven approach to teaching Japanese lexicalization patterns

    The Bilingual Lemma Activation Model as a Comparative Approach to Codeswitching

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    This paper explores intrasentential Codeswitching (CS) as a commonly observed bilingual speech behavior. Different from surface-based models, it investigates CS at an abstract level by relating the nature and activity of the bilingual mental lexicon in bilingual speech production to the structural principles governing CS. The Matrix Language Frame (MLF) Model is adopted for describing some fundamental structural principles governing CS, and the Bilingual Lemma Activation Model (BLA) is proposed for explaining the linguistic motivations for CS. Based on the analysis of some naturally occurring CS instances involving various language pairs, this study supports the claim that one of the bilingual’s languages is activated as the Matrix Language (ML) and the other as the Embedded Language (EL), and content and system morphemes are unequally activated. It is the ML which provides the sentential frame for CS and the EL only provides content morphemes switched into this frame. It further argues that bilingual mental lexicon contains not only lexemes but also more abstract elements called “lemmas”, and lemmas in the bilingual mental lexicon are language-specific and such lemmas are in contact in CS. This study provides evidence that only conceptually activated EL lemmas can be switched into the ML sentential frame

    Identification of molecular subtypes based on PANoptosis-related genes and construction of a signature for predicting the prognosis and response to immunotherapy response in hepatocellular carcinoma

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    BackgroundPrevious studies have demonstrated that PANoptosis is strongly correlated with cancer immunity and progression. This study aimed to develop a PANoptosis-related signature (PANRS) to explore its potential value in predicting the prognosis and immunotherapy response of hepatocellular carcinoma (HCC).MethodsBased on the expression of PANoptosis-related genes, three molecular subtypes were identified. To construct a signature, the differentially expressed genes between different molecular subtypes were subjected to multivariate least absolute shrinkage and selection operator Cox regression analyses. The risk scores of patients in the training set were calculated using the signature. The patients were classified into high-risk and low-risk groups based on the median risk scores. The predictive performance of the signature was evaluated using Kaplan-Meier plotter, receiving operating characteristic curves, nomogram, and calibration curve. The results were validated using external datasets. Additionally, the correlation of the signature with the immune landscape and drug sensitivity was examined. Furthermore, the effect of LPCAT1 knockdown on HCC cell behavior was verified using in vitro experiments.ResultsThis study developed a PANRS. The risk score obtained by using the PANRS was an independent risk factor for the prognosis of patients with HCC and exhibited good prognostic predictive performance. The nomogram constructed based on the risk score and clinical information can accurately predicted the survival probability of patients with HCC. Patients with HCC in the high-risk groups have high immune scores and tend to generate an immunosuppressive microenvironment. They also exhibited a favorable response to immunotherapy, as evidenced by high tumor mutational burden, high immune checkpoint gene expression, high human leukocyte antigen gene expression, low tumor immune dysfunction and low exclusion scores. Additionally, the PANRS enabled the identification of 15 chemotherapeutic agents, including sorafenib, for patients with HCC with different risk levels, guiding clinical treatment. The signature gene LPCAT1 was upregulated in HCC cell lines. LPCAT1 knockdown markedly decreased HCC cell proliferation and migration.ConclusionPANRS can accurately predict the prognosis and immunotherapy response of patients with HCC and consequently guide individualized treatment

    Discovery of Xestophanopsis gen. n. from China and taxonomic revision of two species misplaced in Ceroptres Hartig, 1840 (Hymenoptera, Cynipoidea: Cynipidae)

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    In the present paper, we describe Xestophanopsis Pujade-Villar &Wang gen. n. to the tribe Diastrophini based on Ceroptres distinctusWang, Liu & Chen, 2012 and transfer Ceroptres distinctusWang, Liu&Chen, 2012 to Periclistus Foerster, 1869 as Periclistus setosus (Wang, Liu & Chen, 2012) comb. n. In addition, we report the first record of Periclistus capillatus Kovalev, 1968 from China, along with the first report and description of themale. Finally, we provide a taxonomic key to all Eastern Palaearctic species of the genus Periclistus

    Microbial denitrification characteristics of typical decentralized wastewater treatment processes based on 16S rRNA sequencing

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    Despite the widespread application of decentralized wastewater treatment (WWT) facilities in China, relatively few research has used the multi-media biological filter (MMBF) facilities to investigate the microorganism characteristics. This study utilizes 16S rRNA high-throughput sequencing (HTS) technology to examine the microbial biodiversity of a representative wastewater treatment (WWT) system in an expressway service area. The pathways of nitrogen removal along the treatment route were analyzed in conjunction with water quality monitoring. The distribution and composition of microbial flora in the samples were examined, and the dominant flora were identified using LEfSe analysis. The FAPROTAX methodology was employed to investigate the relative abundance of genes associated with the nitrogen cycle and to discern the presence of functional genes involved in nitrogen metabolism. On average, the method has a high level of efficiency in removing COD, TN, NH3-N, and TP from the effluent. The analysis of the microbial community identified a total of 40 phyla, 111 classes, 143 orders, 263 families, and 419 genera. The phyla that were predominantly observed include Proteobacteria, Acidobacteria, Chloroflexi, Actinobacteria, Nitrospirae, Bacteroidetes. The results show that the system has achieved high performance in nitrogen removal, the abundance of nitrification genes is significantly higher than that of other nitrogen cycle genes such as denitrification, and there are six nitrogen metabolism pathways, primarily nitrification, among which Nitrospirae and Nitrospira are the core differentiated flora that can adapt to low temperature conditions and participate in nitrification, and are the dominant nitrogen removal flora in cold regions. This work aims to comprehensively investigate the diversity and functional properties of the bacterial community in decentralized WWT processes

    The versatile application of cervicofacial and cervicothoracic rotation flaps in head and neck surgery

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    <p>Abstract</p> <p>Background</p> <p>The large defects resulting from head and neck tumour surgeries present a reconstructive challenge to surgeons. Although numerous methods can be used, they all have their own limitations. In this paper, we present our experience with cervicofacial and cervicothoracic rotation flaps to help expand the awareness and application of this useful system of flaps.</p> <p>Methods</p> <p>Twenty-one consecutive patients who underwent repair of a variety of defects of the head and neck with cervicofacial or cervicothoracic flaps in our hospital from 2006 to 2009 were retrospectively analysed. Statistics pertaining to the patients' clinical factors were gathered.</p> <p>Results</p> <p>Cheek neoplasms are the most common indication for cervicofacial and cervicothoracic rotation flaps, followed by parotid tumours. Among the 12 patients with medical comorbidities, the most common was hypertension. Defects ranging from 1.5 cm × 1.5 cm to 7 cm × 6 cm were reconstructed by cervicofacial flap, and defects from 3 cm × 2 cm to 16 cm × 7 cm were reconstructed by cervicothoracic flap. The two flaps also exhibited versatility in these reconstructions. When combined with the pectoralis major myocutaneous flap, the cervicothoracic flap could repair through-and-through cheek defects, and in combination with a temporalis myofacial flap, the cervicofacial flap was able to cover orbital defects. Additionally, 95% patients were satisfied with their resulting contour results.</p> <p>Conclusions</p> <p>Cervicofacial and cervicothoracic flaps provide a technically simple, reliable, safe, efficient and cosmetic means to reconstruct defects of the head and neck.</p
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