Data-driven multinomial random forest

In this article, we strengthen the proof methods of some previously weakly consistent variants of random forests into strongly consistent proof methods, and improve the data utilization of these variants, in order to obtain better theoretical properties and experimental performance. In addition, based on the multinomial random forest (MRF) and Bernoulli random forest (BRF), we propose a data-driven multinomial random forest (DMRF) algorithm, which has lower complexity than MRF and higher complexity than BRF while satisfying strong consistency. It has better performance in classification and regression problems than previous RF variants that only satisfy weak consistency, and in most cases even surpasses standard random forest. To the best of our knowledge, DMRF is currently the most excellent strongly consistent RF variant with low algorithm complexityComment: arXiv admin note: substantial text overlap with arXiv:2211.1515

The transport performance evaluation system building of logistics enterprises

Purpose: modern logistics has a significant role in today’s society, logistics cost accounts for 35% to 50% of total logistics costs, so it’s great significance to improve the transport performance of logistics enterprises. Design/methodology/approach: the authors select the transportation performance evaluation index of logistics enterprise, with the aid of the fuzzy theory and analytic hierarchy process (AHP), adopt the combining method of quantitative and qualitative analysis, construct the transport performance evaluation system of logistics enterprises. Findings: the choice of transport performance evaluation indicator system for Logistics enterprise is in a state of "high", which indicates the indicator selection is reasonable. Research limitations/implications: the selected indicators with experts’ subjective factors can not accurately quantify. Practical implications: it has important practical significance to promote the development of modern logistics enterprises and save social cost. Originality/value: current research methods mainly include the PDCA cycle model, key performance indicators (KPI) and benchmarking method, principal component analysis method, etc. The authors for the first time with the aid of fuzzy theory and analytic hierarchy process (AHP), adopt the combining method of quantitative and qualitative research on transport performance problems.Peer Reviewe

Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549

<p>Abstract</p> <p>Background</p> <p>Klotho, as a new anti-aging gene, can shed into circulation and act as a multi-functional humoral factor that influences multiple biological processes. Recently, published studies suggest that klotho can also serve as a potential tumor suppressor. The aim of this study is to investigate the effects and possible mechanisms of action of klotho in human lung cancer cell line A549.</p> <p>Methods</p> <p>In this study, plasmids encoding klotho or klotho specific shRNAs were constructed to overexpress or knockdown klotho in vitro. A549 cells were respectively treated with pCMV6-MYC-KL or klotho specific shRNAs. The MTT assay was used to evaluate the cytotoxic effects of klotho and flow cytometry was utilized to observe and detect the apoptosis of A549 cells induced by klotho. The activation of IGF-1/insulin signal pathways in A549 cells treated by pCMV6-MYC-KL or shRNAs were evaluated by western blotting. The expression levels of bcl-2 and bax transcripts were evaluated by quantitative reverse transcription-polymerase chain reaction (qRT-PCR).</p> <p>Results</p> <p>Overexpression of klotho reduced the proliferation of lung cancer A549 cells, whereas klotho silencing in A549 cells enhanced proliferation. Klotho did not show any effects on HEK-293 cells. Klotho overexpression in A549 cells was associated with reduced IGF-1/insulin-induced phosphorylation of IGF-1R (IGF-1 receptor)/IR (insulin receptor) (<it>P </it>< 0.01). Overexpression of klotho can promote the apoptosis of A549 cells (<it>P </it>< 0.01). Overexpression of klotho, a bcl family gene bax, was found up-regulated and bcl-2, an anti-apoptosis gene, was found down-regulated (<it>P </it>< 0.01). In contrast, bax and bcl-2 were found down-regulated (<it>P </it>< 0.05) and up-regulated (<it>P </it>< 0.01), respectively when silencing klotho using shRNAs.</p> <p>Conclusions</p> <p>Klotho can inhibit proliferation and increase apoptosis of A549 cells, this may be partly due to the inhibition of IGF-1/insulin pathways and involving regulating the expression of the apoptosis-related genes bax/bcl-2. Thus, klotho can serve as a potential tumor suppressor in A549 cells.</p

A high performance surface acoustic wave visible light sensor using novel materials: Bi2S3 nanobelts

Low dimensional Bi2S3 materials are excellent for use in photodetectors with excellent stability and fast response time. In this work, we developed a visible light sensor with good performance based on surface acoustic wave (SAW) devices using Bi2S3 nanobelts as the sensing materials. The SAW delay-line sensor was fabricated on ST-cut quartz with a designed wavelength of 15.8 microns using conventional photolithography techniques. The measured center frequency was 200.02 MHz. The Bi2S3 nanobelts prepared by a facile hydrothermal process were deposited onto SAW sensors by spin-coating. Under irradiation of 625 nm visible light with a power intensity of 170 μW cm−2, the sensor showed a fast and large response with a frequency upshift of 7 kHz within 1 s. The upshift of the frequency of the SAW device is mainly attributed to the mass loading effect caused by the desorption of oxygen from the Bi2S3 nanobelts under visible light radiation

A computational model for functional mapping of genes that regulate intra-cellular circadian rhythms

BACKGROUND: Genes that control circadian rhythms in organisms have been recognized, but have been difficult to detect because circadian behavior comprises periodically dynamic traits and is sensitive to environmental changes. METHOD: We present a statistical model for mapping and characterizing specific genes or quantitative trait loci (QTL) that affect variations in rhythmic responses. This model integrates a system of differential equations into the framework for functional mapping, allowing hypotheses about the interplay between genetic actions and periodic rhythms to be tested. A simulation approach based on sustained circadian oscillations of the clock proteins and their mRNAs has been designed to test the statistical properties of the model. CONCLUSION: The model has significant implications for probing the molecular genetic mechanism of rhythmic oscillations through the detection of the clock QTL throughout the genome

A high performance surface acoustic wave visible light sensor using novel materials: Bi2S3 nanobelts

Low dimensional Bi2S3 materials are excellent for use in photodetectors with excellent stability and fast response time. In this work, we developed a visible light sensor with good performance based on surface acoustic wave (SAW) devices using Bi2S3 nanobelts as the sensing materials. The SAW delay-line sensor was fabricated on ST-cut quartz with a designed wavelength of 15.8 microns using conventional photolithography techniques. The measured center frequency was 200.02 MHz. The Bi2S3 nanobelts prepared by a facile hydrothermal process were deposited onto SAW sensors by spin-coating. Under irradiation of 625 nm visible light with a power intensity of 170 μW cm−2, the sensor showed a fast and large response with a frequency upshift of 7 kHz within 1 s. The upshift of the frequency of the SAW device is mainly attributed to the mass loading effect caused by the desorption of oxygen from the Bi2S3 nanobelts under visible light radiation

Bifurcation Analysis and Chaos Control in a Discrete-Time Parasite-Host Model

A discrete-time parasite-host system with bifurcation is investigated in detail in this paper. The existence and stability of nonnegative fixed points are explored and the conditions for the existence of flip bifurcation and Neimark-Sacker bifurcation are derived by using the center manifold theorem and bifurcation theory. And we also prove the chaos in the sense of Marotto. The numerical simulations not only illustrate the consistence with the theoretical analysis, but also exhibit other complex dynamical behaviors, such as bifurcation diagrams, Maximum Lyapunov exponents, and phase portraits. More specifically, when the integral step size is chosen as a bifurcation parameter, this paper presents the finding of period orbits, attracting invariant cycles and chaotic attractors of the discrete-time parasite-host system. Specifically, we have stabilized the chaotic orbits at an unstable fixed point by using the feedback control method