Visualizing genotype × phenotype relationships in the GAW15 simulated data

We have developed a graphical display tool called SIMLAPLOT for visualizing different ways in which continuous covariates may influence the genotype-specific risk for complex human diseases. The purpose of our study was to examine continuous covariates in the Genetic Analysis Workshop 15 simulated data set using our novel graphical display tool, with knowledge of the answers. The generated plots provide information about genetic models for the simulated continuous covariates and may help identify the single-nucleotide polymorphisms associated with the underlying quantitative trait loci

Lowering emissivity of concrete roof tile\u27s underside cuts down heat entry to the building

Buildings in Southern China widely use a double-skin roof to reduce heat entry through the roof to the building interior during summertime. Concrete roof tiles are preferably installed as the outmost layer of the double-skin roof due to their resistance to hail and wind damages and their attractive price. However, after construction, the tile’s top tends to be darkened by dust deposit and algae growth, increasing the heat entry through the roof to the building. Here, we show that this heat entry can be curtailed by lowering the emissivity at the tile’s underside. Temperatures and heat fluxes at different elevations of a double-skin roof with concrete tiles as the outmost layer of the roof are monitored. The underside of each concrete tile is coated with a specific paint to get a unique emissivity. Observations reveal that lowering the emissivity of concrete roof tiles could cut down the summer heat gain of buildings in tropical regions

Two-stage study designs for analyzing disease-associated covariates: linkage thresholds and case-selection strategies

The incorporation of disease-associated covariates into studies aiming to identify susceptibility genes for complex human traits is a challenging problem. Accounting for such covariates in genetic linkage and association analyses may help reduce the genetic heterogeneity inherent in these complex phenotypes. For Genetic Analysis Workshop 15 (GAW15) Problem 3 simulated data, our goal was to compare the power of several two-stage study designs to identify rheumatoid arthritis-related genes on chromosome 9 (disease severity), 11 (IgM), and 18 (anti-cyclic citrinullated protein), with knowledge of the answers. Five study designs incorporating an initial linkage step, followed by a case-selection scheme and case-control association analysis by logistic regression, were considered. The linkage step was either qualitative-trait linkage analysis as implemented in MERLIN-nonparametric linkage (NPL), or quantitative-trait locus analysis as implemented in MERLIN-REGRESS. A set of cases representing either one case from each available family, one case per linked family (NPL ≥ 0), or one case from each family identified by ordered-subset analysis was chosen for comparison with the full set of 2000 simulated controls. As expected, the performance of these study designs depended on the disease model used to generate the data, especially the simulated allele frequency difference between cases and controls. The quantitative trait loci analysis performed well in identifying these loci, and the power to identify disease-associated alleles was increased by using ordered-subset analysis as a case selection tool

Research on Performance Degradation Assessment Method of Train Rolling Bearings under Incomplete Data

Abstract-This paper mainly discusses the performance degradation assessment of train rolling bearings under incomplete data, by using the support vector data description (SVDD) and dynamic particle swarm optimization (DPSO).The proposed method is based on the similarity weight for the assessment of the train rolling bearings under incomplete data. Firstly, to obtain effective features of bearing performance degradation from collected vibration data, the local mean decomposition (LMD) is employed to decompose the vibration data. Secondly, the high-dimensionality of features is reduced by the principal component analysis (PCA). And then, on the basis of choosing the kernel parameter and penalty weight, a degradation method based on SVDD is proposed. Finally, the experimental results verified that the proposed method has a better optimization performance than the traditional method and can assess the performance degradation of train rolling bearings under incomplete data

Improved RBF Network Intrusion Detection Model Based on Edge Computing with Multi-algorithm Fusion

Edge computing is difficult to deploy a complete and reliable security strategy due to its distributed computing architecture and inherent heterogeneity of equipment and limited resources. When malicious attacks occur, the loss will be immeasurable. RBF neural network has strong nonlinear representation ability and fast learning convergence speed, which is suitable for intrusion detection of edge detection industrial control network. In this paper, an improved RBF network intrusion detection model based on multi-algorithm fusion is proposed. kernel principal component analysis (KPCA) is used to extract data dimension and simplify data representation. Then subtractive clustering algorithm(SCM) and grey wolf algorithm(GWO) are used to jointly optimize RBF neural network parameters to avoid falling into local optimum, reduce the calculation of model training and improve the detection accuracy. The algorithm can better adapt to the edge computing platform with weak computing ability and bearing capacity, and realize real-time data analysis.The experimental results of BATADAL data set and Gas data set show that the accuracy of the algorithm is over 99% and the training time of larger samples is shortened by 50 times for BATADAL data set. The results show that the improved RBF network is effective in improving the convergence speed and accuracy in intrusion detection

Resilient power grid for smart city

Modern power grid has a fundamental role in the operation of smart cities. However, high impact low probability extreme events bring severe challenges to the security of urban power grid. With an increasing focus on these threats, the resilience of urban power grid has become a prior topic for a modern smart city. A resilient power grid can resist, adapt to, and timely recover from disruptions. It has four characteristics, namely anticipation, absorption, adaptation, and recovery. This paper aims to systematically investigate the development of resilient power grid for smart city. Firstly, this paper makes a review on the high impact low probability extreme events categories that influence power grid, which can be divided into extreme weather and natural disaster, human-made malicious attacks, and social crisis. Then, resilience evaluation frameworks and quantification metrics are discussed. In addition, various existing resilience enhancement strategies, which are based on microgrids, active distribution networks, integrated and multi energy systems, distributed energy resources and flexible resources, cyber-physical systems, and some resilience enhancement methods, including probabilistic forecasting and analysis, artificial intelligence driven methods, and other cutting-edge technologies are summarized. Finally, this paper presents some further possible directions and developments for urban power grid resilience research, which focus on power-electronized urban distribution network, flexible distributed resource aggregation, cyber-physical-social systems, multi-energy systems, intelligent electrical transportation and artificial intelligence and Big Data technology