护理安全品管圈在血管外科护理中的应用效果

Objective: To study the effects of nursing safety quality control circle in the nursing in department of vascular surgery. Methods: Totally 230 patients in vascular surgery department from January 2015 to January 2016 were randomly divided into 2 groups. Assessment the risk factors of disease for each patient , 115 cases in the control group, the shift nurses nurse by traditional method; 115 cases in experimental group ,who were given quality control circle to improve the nursing quality., and the adverse event and compliance,satisfaction to nurses of the patients were compared. Results: The incidence of adverse events and complications (6%) in the experimental group were lower than those in the control group (15.5%). The patients' satisfaction with nurses' job (97.4%) was higher than that of the control group (87%). Conclusion: The implementation of nursing safety quality control circle activities in vascular surgery nursing, effectively reduce the incidence of adverse events and complications during hospitalization, improve the quality of nursing and help patients recover soon.目的  探讨护理安全品管圈在血管外科护理中的应用效果。方法  随机选取2015年1月—2016年1月在本科住院患者230例并随机将其分为两组，对每位患者进行疾病危险因素评估，对照组115例，各交接班护士采用传统护理方法；实验组115例，对患者实施护理安全品管圈活动提高护理质量，比较两组的不良事件和并发症的发生率、患者对护士工作的满意度、患者住院天数。结果  实验组不良事件和并发症的发生率（6%）均低于对照组（15.5%）；患者对护士工作的满意度（97.4%）高于对照组（87%），住院天数较对照组也大大缩短。结论  在血管外科护理中实施护理安全品管圈活动，有效的降低了患者住院期间不良事件和并发症的发生率，提高了护理质量，有助于患者早日康复

Brominated Selinane Sesquiterpenes from the Marine Brown Alga Dictyopteris divaricata

Two new brominated selinane sesquiterpenes, 1-bromoselin-4(14),11-diene (1) and 9-bromoselin-4(14),11-diene (2), one known cadinane sesquiterpene, cadalene (3), and four known selinane sesquiterpenes, α-selinene (4), β-selinene (5), β-dictyopterol (6), and cyperusol C (7), were isolated from a sample of marine brown alga Dictyopteris divaricata collected off the coast of Yantai (China). Their structures were established by detailed MS and NMR spectroscopic analysis, as well as comparison with literature data

Mutation of SLC35D3 causes metabolic syndrome by impairing dopamine signaling in striatal D1 neurons

We thank Dr. Ya-Qin Feng from Shanxi Medical University, Dr. Tian-Yun Gao from Nanjing University and Dr. Yan-Hong Xue from Institute of Biophysics (CAS) for technical assistance in this study. We are very thankful to Drs. Richard T. Swank and Xiao-Jiang Li for their critical reading of this manuscript and invaluable advice. Funding: This work was partially supported by grants from National Basic Research Program of China (2013CB530605; 2014CB942803), from National Natural Science Foundation of China 1230046; 31071252; 81101182) and from Chinese Academy of Sciences (KSCX2-EW-R-05, KJZD-EW-L08). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

Chronically Maternal Exposure to Fenvalerate during Medium-Late Pregnancy Accelerated Cognitive Decline in Middle-Aged Offspring Mice

Epidemiological evidence suggests that pesticide exposure may be involved in the pathogenesis of Alzheimer’s disease (AD). However, whether maternal exposure to fenvalerate (FV) can affect AD-type behaviors in middle-aged offspring has not been determined yet. In this study, CD-1 mothers received 7.5 mg/kg FV or corn oil by gavage daily during gestational days 8–18. Body weight of the offspring was recorded at ages 4–34 weeks. A battery of behavioral tasks was conducted at 13-month, and 5-month-old mice were set as a young control. The results showed that there was insignificant difference in body weight between the FV-treated and control mice. Compared to the young mice, the middle-aged control mice exhibited decreased burrowing activity, decreased spontaneous exploration and sensorimotor ability, increased anxiety, and impaired abilities of spatial and non-spatial learning and memory. Compared to the controls, the FV-treated mice exhibited similar species-typical behaviors, locomotor activity, sensorimotor abilities, but increased anxiety, and decreased abilities of learning and memory. Our results suggested that chronically maternal exposure to FV at a low dose in medium-late gestation could accelerate the impairment in the behaviors of learning and memory and anxiety in the middle-aged offspring, which experience a normal duration of development

Functional Genetic Diversity and Culturability of Petroleum-Degrading Bacteria Isolated From Oil-Contaminated Soils

In this study, we compared the culturability of aerobic bacteria isolated from long-term oil-contaminated soils via enrichment and direct-plating methods; bacteria were cultured at 30°C or ambient temperatures. Two soil samples were collected from two sites in the Shengli oilfield located in Dongying, China. One sample (S0) was close to the outlet of an oil-production water treatment plant, and the other sample (S1) was located 500 m downstream of the outlet. In total, 595 bacterial isolates belonging to 56 genera were isolated, distributed in Actinobacteria, Firmicutes, Bacterioidetes, and Proteobacteria. It was interesting that Actinobacteria and Firmicutes were not detected from the 16S rRNA gene clone library. The results suggested the activation of rare species during culture. Using the enrichment method, 239 isolates (31 genera) and 96 (22 genera) isolates were obtained at ambient temperatures and 30°C, respectively, from S0 soil. Using the direct-plating method, 97 isolates (15 genera) and 163 isolates (20 genera) were obtained at ambient temperatures and 30°C, respectively, from two soils. Of the 595 isolates, 244 isolates (41.7% of total isolates) could degrade n-hexadecane. A greater number of alkane-degraders was isolated at ambient temperatures using the enrichment method, suggesting that this method could significantly improve bacterial culturability. Interestingly, the proportion of alkane degrading isolates was lower in the isolates obtained using enrichment method than that obtained using direct-plating methods. Considering the greater species diversity of isolates obtained via the enrichment method, this technique could be used to increase the diversity of the microbial consortia. Furthermore, phenol hydroxylase genes (pheN), medium-chain alkane monooxygenases genes (alkB and CYP153A), and long-chain alkane monooxygenase gene (almA) were detected in 60 isolates (11 genotypes), 91 isolates (27 genotypes) and 93 isolates (24 genotypes), and 34 isolates (14 genotypes), respectively. This study could provide new insights into microbial resources from oil fields or other environments, and this information will be beneficial for bioremediation of petroleum contamination and for other industrial applications

Nitric oxide (NO) in the Bohai Sea and the Yellow Sea

Nitric oxide (NO) is a short-lived compound of the marine nitrogen cycle; however, our knowledge about its oceanic distribution and turnover is rudimentary. Here we present the measurements of dissolved NO in the surface and bottom layers at 75 stations in the Bohai Sea (BS) and the Yellow Sea (YS) in June 2011. Moreover, NO photoproduction rates were determined at 27 stations in both seas. The NO concentrations in the surface and bottom layers were highly variable and ranged from below the limit of detection (i.e., 32 pmol L−1) to 616 pmol L−1 in the surface layer and 482 pmol L−1 in the bottom layer. There was no significant difference (p>0.05) between the mean NO concentrations in the surface (186±108 pmol L−1) and bottom (174±123 pmol L−1) layers. A decreasing trend of NO in bottom-layer concentrations with salinity indicates a NO input by submarine groundwater discharge. NO in the surface layer was supersaturated at all stations during both day and night and therefore the BS and YS were a persistent source of NO to the atmosphere at the time of our measurements. The average flux was about 4.5×10−16 mol cm−2 s−1 and the flux showed significant positive relationship with the wind speed. The accumulation of NO during daytime was a result of photochemical production, and photoproduction rates were correlated to illuminance. The persistent nighttime NO supersaturation pointed to an unidentified NO dark production. NO sea-to-air flux densities were much lower than the NO photoproduction rates. Therefore, we conclude that the bulk of the NO produced in the mixed layer was rapidly consumed before its release to the atmosphere

Intensity-modulated Radiation Therapy Versus Para-aortic Field Radiotherapy to Treat Para-aortic Lymph Node Metastasis in Cervical Cancer: Prospective Study

Aim To compare dosimetry, efficacy, and toxicity of intensity- modulated radiation therapy (IMRT) with para-aortic field radiotherapy in patients with para-aortic lymph node (PALN) metastasis of cervical cancer. Methods This prospective study examined 60 patients with cervical cancer with PALN metastasis who underwent whole-pelvis radiotherapy followed by brachytherapy between November 1, 2004 and May 31, 2008. After 3 cycles of chemotherapy, patients were serially allocated into two groups and treated with IMRT or para-aortic field RT at doses of 58-68 Gy and 45-50 Gy, respectively. Treatment response was evaluated and toxicities were assessed. Patients in the IMRT group were treated with both para-aortic field RT and IMRT in order to compare the exposure dose of organs at risk. Results In the IMRT group, the mean dose delivered to the planning target volume was 67.5 Gy. At least 99% of the gross tumor volume received effective coverage and radical dose (median, 63.5 Gy; range, 54.5-66) during treatment. IMRT plans yielded better dose conformity to the target and better sparing of the spinal cord and small intestine than para-aortic field RT. The IMRT patients experienced less acute and chronic toxicities. The IMRT group also had higher 2- and 3-year survival rates than the para-aortic RT group (2-year, 58.8% vs 25.0%, P = 0.019; 3-year, 36.4% vs 15.6%, P = 0.016). However, no significant difference was found in 1-year survival (67.7% vs 51.3%, P =0.201). The median survival in the IMRT group was 25 months (range, 3 to 37 months). The actuarial overall survival, disease-free survival, and locoregional control rates at 2 years were 67%, 77%, and 88%, respectively, in the IMRT group. Conclusions IMRT provides better clinical outcomes than para-aortic field radiotherapy in patients with PALN metastasis. However, cervical local and distal recurrence remain a problem. Long-term follow-up and studies involving more patients are needed to confirm our results