Meta-Adapter: An Online Few-shot Learner for Vision-Language Model

The contrastive vision-language pre-training, known as CLIP, demonstrates remarkable potential in perceiving open-world visual concepts, enabling effective zero-shot image recognition. Nevertheless, few-shot learning methods based on CLIP typically require offline fine-tuning of the parameters on few-shot samples, resulting in longer inference time and the risk of over-fitting in certain domains. To tackle these challenges, we propose the Meta-Adapter, a lightweight residual-style adapter, to refine the CLIP features guided by the few-shot samples in an online manner. With a few training samples, our method can enable effective few-shot learning capabilities and generalize to unseen data or tasks without additional fine-tuning, achieving competitive performance and high efficiency. Without bells and whistles, our approach outperforms the state-of-the-art online few-shot learning method by an average of 3.6\% on eight image classification datasets with higher inference speed. Furthermore, our model is simple and flexible, serving as a plug-and-play module directly applicable to downstream tasks. Without further fine-tuning, Meta-Adapter obtains notable performance improvements in open-vocabulary object detection and segmentation tasks.Comment: Accepted by NeurIPS 202

Myocardin immunohistochemistry index is associated with clinical prognosis in nasopharyngeal carcinoma: a clinical practice-based cohort study

Purpose: Recent findings have implicated the role of myocardin re-expression in carcinogenesisHowever, the clinical functions of myocardin in nasopharyngeal carcinoma (NPC) is not known yet. The purpose for the cohort research was to investigate whether myocardin re-expression level may predict clinical prognosis in NPC patients.Methods: 148 NPC patients were recruited from September, 2005 to September, 2011 with median follow-up time of 4.5 years in a clinical practice setting. At study entry myocardin re-expression of these patients was determined using immunohistochemistry (IHC) and additional 20 normal nasopharyngeal tissues were included as control. Two-sample t-test was used to compare mean myocardin reexpression levels and Chi-square test was used for comparing tumour recurrence rate. Logistic regression analysis was used for tumour local control rate, and log-rank test, Kaplan-Meier estimates and Cox proportional hazard model for disease-free survival and overall survival.Results: Myocardin IHC index was significantly downregulated in NPC samples than in normalnasopharyngeal tissues (mean ± standard deviation, 61.2 ±31.5 vs. 109.9 ±73.6, P= 0.009). However, among NPC patients was observed a roughly V-shaped change of myocardin IHC index according to Tumour T-stage (P=0.067); meanwhile higher IHC level was associated with more tumour recurrence rate in NPC patients (High vs. Low: 21.6% vs. 8.1%; P=0.021). Logistic regression analysis equally showed high myocardin IHC level was an independent risk factor for local tumour control rate regardless of adjustments [High vs. Low: unadjusted Odds Ratio (OR) 0.320, 95% confidence interval (CI): 0.117 to 0.871; P=0.026]. Moreover, higher myocardin IHC level was associated with a marginal but not significant risk increase of disease-free survival [High vs. Low: adjusted Hazard Ratio (HR) 1.760, 95% CI: 0.981 to 3.158; log-rank: P=0.129]. A less obvious trend was observed with regard to overall survival [adjusted HR 1.409, 95% CI: 0.715 to 2.77; log-rank: P=0.745].Conclusion: The study results suggested that high myocardin IHC index level could be a potential clinically prognostic intermediate biomarker for tumour recurrence for NPC patients in routine practice. Large well-designed cohort studies involving IHC re-expression change over time is needed

Hemoglobin A1c Levels and Aortic Arterial Stiffness: The Cardiometabolic Risk in Chinese (CRC) Study

Objective: The American Diabetes Association (ADA) recently published new clinical guidelines in which hemoglobin A1c (HbA1c) was recommended as a diagnostic test for diabetes. The present study was to investigate the association between HbA1c and cardiovascular risk, and compare the associations with fasting glucose and 2-hour oral glucose tolerance test (2 h OGTT). Research design and methods: The study samples are from a community-based health examination survey in central China. Carotid-to-femoral pulse wave velocity (cfPWV) and HbA1c were measured in 5,098 men and women. Results: After adjustment for age, sex, and BMI, the levels of HbA1c were significantly associated with an increasing trend of cfPWV in a dose-dependent fashion (P for trend 0.05). Conclusions: HbA1c was related to high cfPWV, independent of conventional cardiovascular risk factors. Senior age and high blood pressure might amplify the adverse effects of HbA1c on cardiovascular risk

Probiotic Therapy for Treating Behavioral and Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review of Clinical Trials

The therapeutic potentials of probiotics in autism spectrum disorder (ASD) remains controversial, with the only existing systematic review on this topic published in 2015. Results from new trials have become available in recent years. We therefore conducted an updated systematic review, to assess the efficacy of probiotics in relieving behavioral symptoms of ASD and gastrointestinal comorbidities. Our review includes two randomized controlled trials, which showed improvement of ASD behaviors, and three open trials, all which exhibited a trend of improvement. Four of these trials concluded from subjective measures that gastrointestinal function indices showed a trend of improvement with probiotic therapy. Additional rigorous trials are needed to evaluate the effects of probiotic supplements in ASD

Characterizing uncertainty in process-based hydraulic modeling, exemplified in a semiarid Inner Mongolia steppe

Assessing root sources of three uncertainties – parameterization of soil hydraulic characteristics, boundary conditions, and estimation of source/sink terms – is a significant challenge in soil water transport modeling. This study aims to evaluate the uncertainty of three each widely-used parameter estimation methods affecting plot-scale water dynamics. The study employs HYDRUS, a process-based hydrologic model, to incorporate these uncertainties and compare model predictions to measured values in a semiarid Inner Mongolia steppe, China. Soil hydraulic parameters are determined using two direct methods (laboratory-derived approach and evaporation method) and one indirect method (neural network). While each hydraulic parameter method generally simulates soil moisture dynamics, the evaporation method performed better, especially under dry conditions. This suggests that measuring the intensity properties, such as unsaturated hydraulic conductivity, with the evaporation method is crucial for reasonable soil moisture simulation. The study also demonstrates the impact of different applied boundary conditions on simulated soil moisture, specifically the partitioning of reference FAO evapotranspiration via one direct method (soil fraction cover) and two indirect methods (leaf area index and crop height). The partitioning via soil fraction cover reflected a better simulation. Additionally, the study compares the uncertainties of root water uptake function with root growth parameters and constant root depth referenced to grass and pasture, and finds no significant difference among them. Comparing three sources of uncertainty in predicting soil moisture, the study concludes that the input soil hydraulic parameter is more sensitive than evapotranspiration partitioning or representation of root water uptake function. Our study highlights that measuring soil intensity properties can better reflect the effects of land use change, such as compaction, on field water transports

Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice

Acknowledgements We thank Miss Jia-Yin and Miss Yu-Ling Sun for their help in breading the mice. Funding This work was supported by grants from the National Natural Science Foundation of China (81200933 to N.-N. Song; 81200692 to L. Chen; 81101026 to Y. Huang; 31528011 to B. Lang; 81221001, 91232724 and 81571332 to Y-Q. Ding), Zhejiang Province Natural Science Foundation of China (LQ13C090004 to C. Zhang), China Postdoctoral Science Foundation (2016 M591714 to C.-C. Qi), and the Fundamental Research Funds for the Central Universities (2013KJ049).Peer reviewedPublisher PD

Analysis of intravitreal injection of triamcinolone acetonide before vitrectomy for retinal detachment associated with choroidal detachment

AIM:To observe the clinical effects of intravitreal injection of triamcinolone acetonide(TA)before vitrectomy for retinal detachment associated with choroidal detachment.METHODS: Totally 23 cases(23 eyes)of retinal detachment associated with choroidal detachment in our hospital were treated by intravitreal injection of TA 4-5d before 23-Gauge micro-invasive vitrectomy combined with silicone oil injection. All the cases were followed up between 6 to 9mo. The anatomic retinal reattachment, visual acuity, intraocular pressure and postoperative complications were observed and analyzed. RESULTS: After the surgery, the visual acuity of all patients were improved, with 9 eyes better than 0.3(39%), and 18 eyes better than 0.05(78%). The BCVA at 1wk, 1 and 3mo and last follow up were different compared with before operations(PPPCONCLUSION: Intravitreal injection of TA before vitrectomy for retinal detachment associated with choroidal could improve the clinical effects, and decrease the difficulty of surgery while the injection itself is pretty safe