5,468 research outputs found
Investment in Concealable Information
Session ID 59: Principal-Agent ModelsA sender who wants to influence a decision maker has no incentive
to collect information if he has to reveal all evidence so obtained, because the
expected value of posterior belief is equal to the prior. If he can conceal his
evidence at a cost, he invests more in obtaining information when this cost
is lower, and this dampens the incentive to conceal evidence as the decision
maker would become skeptical upon hearing nothing. In equilibrium greater
freedom to conceal information may lead to greater information revelation.
A sender has less incentive to conceal evidence when there is another sender
who can obtain conditionally independent information, regardless of whether
the other sender has the same or the opposite bias.published_or_final_versio
Optimizing hydropower reservoir operation using hybrid genetic algorithm and chaos
Author name used in this publication: Chun-tian CheungAuthor name used in this publication: K. W. Chau2008-2009 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe
Modeling and identification of gene regulatory networks: A Granger causality approach
It is of increasing interest in systems biology to discover gene regulatory networks (GRNs) from time-series genomic data, i.e., to explore the interactions among a large number of genes and gene products over time. Currently, one common approach is based on Granger causality, which models the time-series genomic data as a vector autoregressive (VAR) process and estimates the GRNs from the VAR coefficient matrix. The main challenge for identification of VAR models is the high dimensionality of genes and limited number of time points, which results in statistically inefficient solution and high computational complexity. Therefore, fast and efficient variable selection techniques are highly desirable. In this paper, an introductory review of identification methods and variable selection techniques for VAR models in learning the GRNs will be presented. Furthermore, a dynamic VAR (DVAR) model, which accounts for dynamic GRNs changing with time during the experimental cycle, and its identification methods are introduced. © 2010 IEEE.published_or_final_versionThe 9th International Conference on Machine Learning and Cybernetics (ICMLC 2010), Qingdao, China, 11-14 July 2010. In Proceedings of the 9th ICMLC, 2010, v. 6, p. 3073-307
Thermodynamics of carrier distribution within localized electronic states with a broad Gaussian energy distribution and its effect on luminescence behavior of localized states
published_or_final_versio
Thermal redistribution of localized excitons and its effect on the luminescence band in InGaN ternary alloys
Temperature-dependent photoluminescence measurements have been carried out in zinc-blende InGaN epilayers grown on GaAs substrates by metalorganic vapor-phase epitaxy. An anomalous temperature dependence of the peak position of the luminescence band was observed. Considering thermal activation and the transfer of excitons localized at different potential minima, we employed a model to explain the observed behavior. A good agreement between the theory and the experiment is achieved. At high temperatures, the model can be approximated to the band-tail-state emission model proposed by Eliseev et al. [Appl. Phys. Lett. 71, 569 (1997)]. © 2001 American Institute of Physics.published_or_final_versio
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Mechanistic Modeling of Microtopographic Impacts on CO2 and CH4 Fluxes in an Alaskan Tundra Ecosystem Using the CLM-Microbe Model
Spatial heterogeneities in soil hydrology have been confirmed as a key control on CO2 and CH4 fluxes in the Arctic tundra ecosystem. In this study, we applied a mechanistic ecosystem model, CLM-Microbe, to examine the microtopographic impacts on CO2 and CH4 fluxes across seven landscape types in Utqiaġvik, Alaska: trough, low-centered polygon (LCP) center, LCP transition, LCP rim, high-centered polygon (HCP) center, HCP transition, and HCP rim. We first validated the CLM-Microbe model against static-chamber measured CO2 and CH4 fluxes in 2013 for three landscape types: trough, LCP center, and LCP rim. Model application showed that low-elevation and thus wetter landscape types (i.e., trough, transitions, and LCP center) had larger CH4 emissions rates with greater seasonal variations than high-elevation and drier landscape types (rims and HCP center). Sensitivity analysis indicated that substrate availability for methanogenesis (acetate, CO2 + H2) is the most important factor determining CH4 emission, and vegetation physiological properties largely affect the net ecosystem carbon exchange and ecosystem respiration in Arctic tundra ecosystems. Modeled CH4 emissions for different microtopographic features were upscaled to the eddy covariance (EC) domain with an area-weighted approach before validation against EC-measured CH4 fluxes. The model underestimated the EC-measured CH4 flux by 20% and 25% at daily and hourly time steps, suggesting the importance of the time step in reporting CH4 flux. The strong microtopographic impacts on CO2 and CH4 fluxes call for a model-data integration framework for better understanding and predicting carbon flux in the highly heterogeneous Arctic landscape
Fine structural changes of fluid catalytic catalysts and characterization of coke formed resulting from heavy oil devolatilization
Coke formation from heavy oil cracking and the associated change in the porous structure of fluid catalytic cracking (FCC) catalysts has been studied using a comprehensive range of techniques, including 2D and 3D imaging and carbon/coke characterization techniques. The carbon/coke formed from heavy oil devolatilization has been investigated with a range of oil-to-FCC catalyst ratios (1:3, 1:2, 1:1, 2:1 and 3:1) to simulate the ageing of FCC catalysts in an operating oil refinery. Carbon/coke was formed on all used FCC catalyst samples and was found to generally increase in quantity with the increasing oil-to-FCC catalyst ratios. Coke formation has been correlated with the observed porosity change of the FCC catalyst. Higher quantities of carbon/coke formed on the FCC catalyst due to higher oil-to-FCC catalyst ratios (simulated increase in time on-stream) leads to a decrease of total pore volume and surface area. X-Ray computed tomography (X-Ray CT) studies allowed 3-dimensional imaging of used catalyst particles and showed that the zeolite component of the FCC catalyst remains evenly distributed throughout the FCC particle from the centre to the exterior for pristine and used FCC catalyst particles. This technique showed that while the interior porous structure of the FCC catalyst particle is not affected by the coking, the exterior porous structure is substantially modified for all used FCC catalyst samples. This process of pore collapse and/or clogging at the surface of the particles is likely to have a significant effect on the deactivation of FCC catalysts that is commonly observed. The deeper insight into this process gained through this study is important for understanding how FCC catalysts change with time-on-stream and eventually deactivate and may allow for future catalysts to be developed that are more resistant to deactivation
A HIV-1 heterosexual transmission chain in Guangzhou, China: a molecular epidemiological study
<p>Abstract</p> <p>Background</p> <p>We conducted molecular analyses to confirm four clustering HIV-1 infections (Patient A, B, C & D) in Guangzhou, China. These cases were identified by epidemiological investigation and suspected to acquire the infection through a common heterosexual transmission chain.</p> <p>Methods</p> <p><it>Env C2V3V4 </it>region, <it>gag p17/p24 </it>junction and partial <it>pol </it>gene of HIV-1 genome from serum specimens of these infected cases were amplified by reverse transcription polymerase chain reaction (RT-PCR) and nucleotide sequenced.</p> <p>Results</p> <p>Phylogenetic analyses indicated that their viral nucleotide sequences were significantly clustered together (bootstrap value is 99%, 98% and 100% in <it>env</it>, <it>gag </it>and <it>pol </it>tree respectively). Evolutionary distance analysis indicated that their genetic diversities of <it>env</it>, <it>gag </it>and <it>pol </it>genes were significantly lower than non-clustered controls, as measured by unpaired <it>t</it>-test (<it>env </it>gene comparison: <it>p </it>< 0.005; <it>gag </it>gene comparison: <it>p </it>< 0.005; <it>pol </it>gene comparison: <it>p </it>< 0.005).</p> <p>Conclusion</p> <p>Epidemiological results and molecular analyses consistently illustrated these four cases represented a transmission chain which dispersed in the locality through heterosexual contact involving commercial sex worker.</p
Experimental study of regenerative EM -TMD system for building vibration control
Author name used in this publication: S. ZhuRefereed conference paper2011-2012 > Academic research: refereed > Refereed conference paperVersion of RecordPublishe
Wnt5a induces ROR1 to complex with HS1 to enhance migration of chronic lymphocytic leukemia cells.
ROR1 (receptor tyrosine kinase-like orphan receptor 1) is a conserved, oncoembryonic surface antigen expressed in chronic lymphocytic leukemia (CLL). We found that ROR1 associates with hematopoietic-lineage-cell-specific protein 1 (HS1) in freshly isolated CLL cells or in CLL cells cultured with exogenous Wnt5a. Wnt5a also induced HS1 tyrosine phosphorylation, recruitment of ARHGEF1, activation of RhoA and enhanced chemokine-directed migration; such effects could be inhibited by cirmtuzumab, a humanized anti-ROR1 mAb. We generated truncated forms of ROR1 and found its extracellular cysteine-rich domain or kringle domain was necessary for Wnt5a-induced HS1 phosphorylation. Moreover, the cytoplamic, and more specifically the proline-rich domain (PRD), of ROR1 was required for it to associate with HS1 and allow for F-actin polymerization in response to Wnt5a. Accordingly, we introduced single amino acid substitutions of proline (P) to alanine (A) in the ROR1 PRD at positions 784, 808, 826, 841 or 850 in potential SH3-binding motifs. In contrast to wild-type ROR1, or other ROR1P→︀A mutants, ROR1P(841)A had impaired capacity to recruit HS1 and ARHGEF1 to ROR1 in response to Wnt5a. Moreover, Wnt5a could not induce cells expressing ROR1P(841)A to phosphorylate HS1 or activate ARHGEF1, and was unable to enhance CLL-cell motility. Collectively, these studies indicate HS1 plays an important role in ROR1-dependent Wnt5a-enhanced chemokine-directed leukemia-cell migration
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