Modeling on spatial block topological identification and the irprogressive failure analysis of slopeand cavernrock mass

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6,7,8,14,15,16-Hexaphenyldibenzo[c,gh]naphtho[3,2,1,8-pqra]tetraphene-5,13-dione dichloromethane monosolvate

The main mol­ecule of the title compound, C66H38O2·CH2Cl2, is centrosymmetric, the asymmetric unit is composed of two half-mol­ecules, located on inversion centers, and a mol­ecule of dichloro­methane. The large π-conjugated fused polycyclic system including eight six-membered rings is nearly planar, with r.m.s. deviations of 0.2114 and 0.2081 Å in the two independent mol­ecules

Programmed cell death 4 (PDCD4) suppresses metastastic potential of human hepatocellular carcinoma cells

<p>Abstract</p> <p>Background</p> <p>Hepatocellular carcinoma (HCC) is a lethal malignancy with high rate of metastasis and poor prognosis. There are no effective managements to block metastasis of HCC. Programmed cell death 4 (PDCD4) is found to be a tumor transformation suppressor. Among investigations on effects of PDCD4, little is about the metastatic potentials of HCC cells. This study was to investigate the role of PDCD4 on metastatic potential of human HCC cells.</p> <p>Methods</p> <p>We examined the expression of PDCD4 in three HCC cell lines with different metastatic potentials, MHCC-97H (high metastatic potential), MHCC-97L (low metastatic potential) and Hep3B (no metastatic potential). A plasmid encoding PDCD4 gene was constructed and then transfected into HCC cells with the lowest PDCD4 expression level. Effects of PDCD4 on cell proliferation, cell apoptosis, gene expression of metastasis tumor antigen 1 (MTA1) and in vitro migration and invasion capacity were assessed after transfection.</p> <p>Results</p> <p>Our results showed that the expression level of PDCD4 was inversely correlated to the metastatic potential of HCC cells. After transfection with the PDCD4 gene, HCC cell proliferation rate was significantly decreased, cell apoptosis rate was significantly increased, the expression of MTA1 gene, HCC cell migration and Matrigel invasion were also remarkably inhibited.</p> <p>Conclusion</p> <p>PDCD4 expression is inversely correlated to the metastatic potential of HCC cells. PDCD4 can effectively suppress the metastatic potential of HCC cells.</p

中国现代抒情小说研究--解读郁达夫、废名、沈从文 = Lyrical fiction in modern China: Studies in Yu Dafu, Fei Min , and Shen Congwen

Ph.DDOCTOR OF PHILOSOPH

Imaging and spectral study on the null point of a fan-spine structure during a solar flare

Using the multi-instrument observations, we make the first simultaneous imaging and spectral study on the null point of a fan-spine magnetic topology during a solar flare. When magnetic reconnection occurs at the null point, the fan-spine configuration brightens in the (extreme-)ultraviolet channels. In the H$\alpha$ images, the fan-spine structure is partly filled and outlined by the bi-directional material flows ejected from the reconnection site. The extrapolated coronal magnetic field confirms the existence of the fan-spine topology. Before and after the flare peak, the total velocity of the outflows is estimated to be about 60 km s$^{-1}$. During the flare, the Si IV line profile at the reconnection region is enhanced both in the blue-wing and red-wing. At the flare peak time, the total velocity of the outflows is found to be 144 km s$^{-1}$. Superposed on the Si IV profile, there are several deep absorption lines with the blueshift of several tens of km s$^{-1}$. The reason is inferred to be that the bright reconnection region observed in Si IV channel is located under the cooler material appearing as dark features in the H$\alpha$ line. The blueshifted absorption lines indicate the movement of the cooler material toward the observer. The depth of the absorption lines also depends on the amount of cooler material. These results imply that this kind of spectral profiles can be used as a tool to diagnose the properties of cooler material above reconnection site.Comment: Accepted for publication in Ap

Fully Homomorphic Encryption with k-bit Arithmetic Operations

We present a fully homomorphic encryption scheme continuing the line of works of Ducas and Micciancio (2015, [DM15]), Chillotti et al. (2016, [CGGI16a]; 2017, [CGGI17]; 2018, [CGGI18a]), and Gao (2018,[Gao18]). Ducas and Micciancio (2015) show that homomorphic computation of one bit operation on LWE ciphers can be done in less than a second, which is then reduced by Chillotti et al. (2016, 2017, 2018) to 13ms. According to Chillotti et al. (2018, [CGGI18b]), the cipher expansion for TFHE is still 8000. The ciphertext expansion problem was greatly reduced by Gao (2018) to 6 with private-key encryption and 20 for public key encryption. The bootstrapping in Gao (2018) is only done one bit at a time, and the bootstrapping design matches the previous two works in efficiency. Our contribution is to present a fully homomorphic encryption scheme based on these preceding schemes that generalizes the Gao (2018) scheme to perform operations on k-bit encrypted data and also removes the need for the Independence Heuristic of the Chillotti et al. papers. The amortized cost of computing k-bits at a time improves the efficiency. Operations supported include addition and multiplication modulo $2^k$, addition and multiplication in the integers as well as exponentiation, field inversion and the machine learning activation function RELU. The ciphertext expansion factor is also further improved, for $k = 4$ our scheme achieves a ciphertext expansion factor of 2.5 under secret key and 6.5 under public key. Asymptotically as k increases, our scheme achieves the optimal ciphertext expansion factor of 1 under private key encryption and 2 under public key encryption. We also introduces techniques for reducing the size of the bootstrapping key. Keywords. FHE, lattices, learning with errors (LWE), ring learning with errors (RLWE), TFHE, data security, RELU, machine learnin