Perception of Food Safety Risk from Animal Contact Questionnaire for Extension Audiences

Animal contact in public settings for both leisure and work increases the odds of infectious diseases. This circumstance is exacerbated by inadequate understanding of the connection between exposure to animals and food safety risks. The purpose of our research was to develop a survey for assessing adults\u27 perceptions of food safety risk from exposure to animals. Results of our study suggest that the survey has acceptable internal structure and reliability. It may prove useful to Extension professionals who are assessing the need for associated programming or seeking to track progress toward relevant outcomes

Robust Transmissions in Wireless Powered Multi-Relay Networks with Chance Interference Constraints

In this paper, we consider a wireless powered multi-relay network in which a multi-antenna hybrid access point underlaying a cellular system transmits information to distant receivers. Multiple relays capable of energy harvesting are deployed in the network to assist the information transmission. The hybrid access point can wirelessly supply energy to the relays, achieving multi-user gains from signal and energy cooperation. We propose a joint optimization for signal beamforming of the hybrid access point as well as wireless energy harvesting and collaborative beamforming strategies of the relays. The objective is to maximize network throughput subject to probabilistic interference constraints at the cellular user equipment. We formulate the throughput maximization with both the time-switching and power-splitting schemes, which impose very different couplings between the operating parameters for wireless power and information transfer. Although the optimization problems are inherently non-convex, they share similar structural properties that can be leveraged for efficient algorithm design. In particular, by exploiting monotonicity in the throughput, we maximize it iteratively via customized polyblock approximation with reduced complexity. The numerical results show that the proposed algorithms can achieve close to optimal performance in terms of the energy efficiency and throughput.Comment: 14 pages, 8 figure

Hybrid spintronic materials:Growth, structure and properties

10.1016/j.pmatsci.2018.08.001Progress in Materials Science9927-10

Common fixed point theorems for cyclic contractive mappings in partial cone b-metric spaces and applications to integral equations

In this paper, we introduce the concept of partial cone b-metric spaces as a generalization of partial metric, cone metric and b-metric spaces and establish some topological properties of partial cone b-metric spaces. Moreover, we also prove some common fixed point theorems for cyclic contractive mappings in such spaces. Our results generalize and extend the main results of Huang and Zhang [Cone metric spaces and fixed point theorems of contractive mappings, J. Math. Anal. Appl., 332:1468–1476, 2007], Stanić et al. [Common fixed point under contractive condition of Ćirić's type on cone metric type spaces, Fixed Point Theory Appl., 2012:35, 2012] and Latif et al. [Fixed point results for generalized (α,ψ)‐Meir–Keeler contractive mappings and applications, J. Inequal. Appl., 2014:68, 2014]. Some examples and an application are given to support the usability of the obtained results

Co-crystalization and in vitro biological characterization of 5-Aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors

A potential therapeutic strategy for targeting cancer that has gained much interest is the inhibition of the ATP binding and ATPase activity of the molecular chaperone Hsp90. We have determined the structure of the human Hsp90α N-terminal domain in complex with a series of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazoles. The structures provide the molecular details for the activity of these inhibitors. One of these inhibitors, ICPD 34, causes a structural change that affects a mobile loop, which adopts a conformation similar to that seen in complexes with ADP, rather than the conformation generally seen with the pyrazole/isoxazole-resorcinol class of inhibitors. Competitive binding to the Hsp90 N-terminal domain was observed in a biochemical assay, and these compounds showed antiproliferative activity and induced apoptosis in the HCT116 human colon cancer cell line. These inhibitors also caused induction of the heat shock response with the upregulation of Hsp72 and Hsp27 protein expression and the depletion of Hsp90 clients, CRAF, ERBB2 and CDK4, thus confirming that antiproliferative activity was through the inhibition of Hsp90. The presence of increased levels of the cleavage product of PARP indicated apoptosis in response to Hsp90 inhibitors. This work provides a framework for the further optimization of thiadiazole inhibitors of Hsp90. Importantly, we demonstrate that the thiadiazole inhibitors display a more limited core set of interactions relative to the clinical trial candidate NVP-AUY922, and consequently may be less susceptible to resistance derived through mutations in Hsp9