Decoherence in a Josephson junction qubit

The zero-voltage state of a Josephson junction biased with constant current consists of a set of metastable quantum energy levels. We probe the spacings of these levels by using microwave spectroscopy to enhance the escape rate to the voltage state. The widths of the resonances give a measurement of the coherence time of the two states involved in the transitions. We observe a decoherence time shorter than that expected from dissipation alone in resonantly isolated 20 um x 5 um Al/AlOx/Al junctions at 60 mK. The data is well fit by a model including dephasing effects of both low-frequency current noise and the escape rate to the continuum voltage states. We discuss implications for quantum computation using current-biased Josephson junction qubits, including the minimum number of levels needed in the well to obtain an acceptable error limit per gate.Comment: 4 pages, 6 figure

Nernst Effect and Anomalous Transport in Cuprates: A Preformed-Pair Alternative to the Vortex Scenario

We address those puzzling experiments in underdoped high $T_c$ superconductors which have been associated with normal state "vortices" and show these data can be understood as deriving from preformed pairs with onset temperature $T^* > T_c$. For uncorrelated bosons in small magnetic fields, and arbitrary $T^*/T_c$, we present the exact contribution to \textit{all} transport coefficients. In the overdoped regime our results reduce to those of standard fluctuation theories ($T^*\approx T_c$). Semi-quantitative agreement with Nernst, ac conductivity and diamagnetic measurements is quite reasonable.Comment: 9 pages, 4 figures; Title, abstract and contents modified, new references added, figures changed, one more figure added; to be published on PR

An Exact Algorithm for Side-Chain Placement in Protein Design

Computational protein design aims at constructing novel or improved functions on the structure of a given protein backbone and has important applications in the pharmaceutical and biotechnical industry. The underlying combinatorial side-chain placement problem consists of choosing a side-chain placement for each residue position such that the resulting overall energy is minimum. The choice of the side-chain then also determines the amino acid for this position. Many algorithms for this NP-hard problem have been proposed in the context of homology modeling, which, however, reach their limits when faced with large protein design instances. In this paper, we propose a new exact method for the side-chain placement problem that works well even for large instance sizes as they appear in protein design. Our main contribution is a dedicated branch-and-bound algorithm that combines tight upper and lower bounds resulting from a novel Lagrangian relaxation approach for side-chain placement. Our experimental results show that our method outperforms alternative state-of-the art exact approaches and makes it possible to optimally solve large protein design instances routinely

Radiative capture and electromagnetic dissociation involving loosely bound nuclei: the 8^8B example

Electromagnetic processes in loosely bound nuclei are investigated using an analytical model. In particular, electromagnetic dissociation of $^8$B is studied and the results of our analytical model are compared to numerical calculations based on a three-body picture of the $^8$B bound state. The calculation of energy spectra is shown to be strongly model dependent. This is demonstrated by investigating the sensitivity to the rms intercluster distance, the few-body behavior, and the effects of final state interaction. In contrast, the fraction of the energy spectrum which can be attributed to E1 transitions is found to be almost model independent at small relative energies. This finding is of great importance for astrophysical applications as it provides us with a new tool to extract the E1 component from measured energy spectra. An additional, and independent, method is also proposed as it is demonstrated how two sets of experimental data, obtained with different beam energy and/or minimum impact parameter, can be used to extract the E1 component.Comment: Submitted to Phys. Rev. C. 10 pages, 7 figure

Dynamical Structure Factor for the Alternating Heisenberg Chain: A Linked Cluster Calculation

We develop a linked cluster method to calculate the spectral weights of many-particle excitations at zero temperature. The dynamical structure factor is expressed as a sum of exclusive structure factors, each representing contributions from a given set of excited states. A linked cluster technique to obtain high order series expansions for these quantities is discussed. We apply these methods to the alternating Heisenberg chain around the dimerized limit ($\lambda=0$), where complete wavevector and frequency dependent spectral weights for one and two-particle excitations (continuum and bound-states) are obtained. For small to moderate values of the inter-dimer coupling parameter $\lambda$, these lead to extremely accurate calculations of the dynamical structure factors. We also examine the variation of the relative spectral weights of one and two-particle states with bond alternation all the way up to the limit of the uniform chain ($\lambda=1$). In agreement with Schmidt and Uhrig, we find that the spectral weight is dominated by 2-triplet states even at $\lambda=1$, which implies that a description in terms of triplet-pair excitations remains a good quantitative description of the system even for the uniform chain.Comment: 26 pages, 17 figure

An analysis of the FIR/RADIO Continuum Correlation in the Small Magellanic Cloud

The local correlation between far-infrared (FIR) emission and radio-continuum (RC) emission for the Small Magellanic Cloud (SMC) is investigated over scales from 3 kpc to 0.01 kpc. Here, we report good FIR/RC correlation down to ~15 pc. The reciprocal slope of the FIR/RC emission correlation (RC/FIR) in the SMC is shown to be greatest in the most active star forming regions with a power law slope of ~1.14 indicating that the RC emission increases faster than the FIR emission. The slope of the other regions and the SMC are much flatter and in the range of 0.63-0.85. The slopes tend to follow the thermal fractions of the regions which range from 0.5 to 0.95. The thermal fraction of the RC emission alone can provide the expected FIR/RC correlation. The results are consistent with a common source for ultraviolet (UV) photons heating dust and Cosmic Ray electrons (CRe-s) diffusing away from the star forming regions. Since the CRe-s appear to escape the SMC so readily, the results here may not provide support for coupling between the local gas density and the magnetic field intensity.Comment: 19 pages, 7 Figure

Spectral properties of the dimerized and frustrated S=1/2S=1/2 chain

Spectral densities are calculated for the dimerized and frustrated S=1/2 chain using the method of continuous unitary transformations (CUTs). The transformation to an effective triplon model is realized in a perturbative fashion up to high orders about the limit of isolated dimers. An efficient description in terms of triplons (elementary triplets) is possible: a detailed analysis of the spectral densities is provided for strong and intermediate dimerization including the influence of frustration. Precise predictions are made for inelastic neutron scattering experiments probing the S=1 sector and for optical experiments (Raman scattering, infrared absorption) probing the S=0 sector. Bound states and resonances influence the important continua strongly. The comparison with the field theoretic results reveals that the sine-Gordon model describes the low-energy features for strong to intermediate dimerization only at critical frustration.Comment: 21 page

Cost-effectiveness of pembrolizumab as second-line therapy for the treatment of locally advanced or metastatic urothelial carcinoma in Sweden

Background: Urothelial carcinoma (UC) is the most common subtype of bladder cancer. The randomized phase 3 KEYNOTE-045 trial showed that pembrolizumab, used as second-line therapy significantly prolonged overall survival with fewer treatment-related adverse events than chemotherapy for advanced UC. Pembro- lizumab has been approved by the European Medicines Agency for the treatment of locally advanced or metastatic UC in adults who have received platinum-contain- ing chemotherapy. Many European countries use cost-effectiveness analysis to inform reimbursement decisions. Objective: To assess the cost-effectiveness of pembrolizumab as second-line ther- apy for the treatment of advanced UC from a Swedish health care perspective. Design, setting, and participants: We developed a partitioned-survival model to assess the costs and effectiveness of pembrolizumab compared with vinflunine (base case), paclitaxel, or docetaxel monotherapy in patients with advanced UC over a 15-yr time horizon. We obtained Kaplan-Meier estimates for survival end- points, adverse events, and utility data from KEYNOTE-045. Outcome measurements and statistical analysis: We performed parametric extra- polations to estimate overall and progression-free survival beyond the clinical trial period. Swedish costs and utility weights were used to estimate total costs, quality- adjusted life years (QALYs), and incremental cost-effectiveness ratios (ICERs). We performed deterministic and probabilistic sensitivity analyses to assess the ro- bustness of the model results. Results and limitations: In the base-case analysis, pembrolizumab resulted in a mean survival gain of 1.66 years (1.38 QALYs) at an incremental cost of s69 852 and an ICER of s50 529/QALY gained versus vinflunine monotherapy. ICERs for other chemotherapies were s81 356/QALY for pembrolizumab versus paclitaxel or doc- etaxel monotherapy, and s71924/QALY for pembrolizumab versus paclitaxel, docetaxel, or vinflunine monotherapy. Long-term follow-up from KEYNOTE-045 and real-world data are needed to validate the extrapolations