Demonstration of the double Q^2-rescaling model

In this paper we have demonstrated the double Q^2-rescaling model (DQ^2RM) of parton distribution functions of nucleon bounded in nucleus. With different x-region of l-A deep inelastic scattering process we take different approach: in high x-region (0.1\le x\le 0.7) we use the distorted QCD vacuum model which resulted from topologically multi -connected domain vacuum structure of nucleus; in low x-region (10^{-4}\le x\le10^{-3}) we adopt the Glauber (Mueller) multi- scattering formula for gluon coherently rescattering in nucleus. From these two approach we justified the rescaling parton distribution functions in bound nucleon are in agreement well with those we got from DQ^2RM, thus the validity for this phenomenologically model are demonstrated.Comment: 19 page, RevTex, 5 figures in postscrip

J/ψ+jetJ/\psi + jet diffractive production in the direct photon process at HERA

We present a study of $J/\psi + jet$ diffractive production in the direct photon process at HERA based on the factorization theorem for lepton-induced hard diffractive scattering and the factorization formalism of the nonrelativistic QCD (NRQCD) for quarkonia production. Using the diffractive gluon distribution function extracted from HERA data on diffractive deep inelastic scattering and diffractive dijet photon production, we show that this process can be studied at HERA with present integrated luminosity, and can give valuable insights in the color-octet mechanism for heavy quarkonia production.Comment: Revtex, 21 pages, 7 EPS figure

Novel GATA5 loss-of-function mutations underlie familial atrial fibrillation

OBJECTIVE: This study aimed to identify novel GATA5 mutations that underlie familial atrial fibrillation. METHODS: A total of 110 unrelated patients with familial atrial fibrillation and 200 unrelated, ethnically matched healthy controls were recruited. The entire coding region of the GATA5 gene was sequenced in 110 atrial fibrillation probands. The available relatives of the mutation carriers and 200 controls were subsequently genotyped for the identified mutations. The functional effect of the mutated GATA5 was characterized using a luciferase reporter assay system. RESULTS: Two novel heterozygous GATA5 mutations (p.Y138F and p.C210G) were identified in two of the 110 unrelated atrial fibrillation families. These missense mutations cosegregated with AF in the families and were absent in the 400 control chromosomes. A cross-species alignment of GATA5 protein sequence showed that the altered amino acids were completely conserved evolutionarily. A functional analysis revealed that the mutant GATA5 proteins were associated with significantly decreased transcriptional activation when compared with their wild-type counterpart. CONCLUSION: The findings expand the spectrum of GATA5 mutations linked to AF and provide novel insights into the molecular mechanism involved in the pathogenesis of atrial fibrillation, suggesting potential implications for the early prophylaxis and personalized treatment of this common arrhythmia

Thiamine Deficiency Causes Long-Lasting Neurobehavioral Deficits in Mice

Thiamine deficiency (TD) has detrimental effects on brain health and neurobehavioral development, and it is associated with many aging-related neurological disorders. To facilitate TD-related neuropsychological studies, we generated a TD mouse model by feeding a thiamine-deficient diet for 30 days, followed by re-feeding the control diet for either one week or 16 weeks as recovery treatment. We then performed neurobehavioral tests in these two cohorts: cohort of one week post TD treatment (1 wk-PTDT) and 16 weeks post TD treatment (16 wks-PTDT). The TD mice showed no significant difference from control in any tests in the 1 wk-PTDT cohort at the age of 13–14 weeks. The tests for the 16 wks-PTDT cohort at the age of 28–29 weeks, however, demonstrated anxiety and reduced locomotion in TD animals in open field and elevated plus maze. In comparison, rotor rod and water maze revealed no differences between TD and control mice. The current findings of the differential effects of the same TD treatment on locomotion and anxiety at different ages may reflect the progressive and moderate change of TD-induced neurobehavioral effects. The study suggests that, even though the immediate neurobehavioral impact of TD is modest or negligible at a young age, the impact could develop and become severe during the aging process

心理资本干预对抑郁症患者的影响

Objective: To explore the effect of psychological capital intervention on the depressed patients. Method: 62 patients with depression were randomly divided into control group and experimental group. Control group was taken with drug treatment, experimental group was taken with drug treatment and psychological capital intervention. Two groups of patients had been evaluated by psychological capital questionnaire (PPQ) and depression self rating scale (SDS) , before and after treatment. Results: After treatment, the two groups of patients’ scores of PPQ and SDS both dropped significantly. The treatment results of the experimental group was better than the control group. Conclusion: In conventional drug treatment with psychological intervention of capital at the same time, can efetively improve the patients’ level of psychological capital, significantly alleviate symptoms of depression.目的：探讨心理资本干预在抑郁症治疗中的影响。方法：将62例患者随机分为对照组和实验组。对照组给予药物常规治疗，实验组在常规治疗的基础上同时辅以心理资本干预。两组均在首诊及治疗6周后，采用心理资本问卷（PPQ）和抑郁自评量表（SDS）进行评定。结果：治疗后，两组患者的心理资本问卷、抑郁自评表得分均下降显著；实验组效果明显优于对照组。结论：在常规药物治疗的同时辅以心理资本干预，能有效提高患者的心理资本水平，显著缓解抑郁症状

Modulating Linker Composition of Haptens Resulted in Improved Immunoassay for Histamine.

Histamine (HA) is an important food contaminant generated during food fermentation or spoilage. However, an immunoassay for direct (derivatization free) determination of HA has rarely been reported due to its small size to induce the desired antibodies by its current hapten-protein conjugates. In this work, despite violating the classical hapten design criteria which recommend introducing a linear aliphatic (phenyl free) linker into the immunizing hapten, a novel haptens, HA-245 designed and synthesized with a phenyl-contained linker, exhibited significantly enhanced immunological properties. Thus, a quality-improved monoclonal antibody (Mab) against HA was elicited by its hapten-carrier conjugates. Then, as the linear aliphatic linker contained haptens, Hapten B was used as linker-heterologous coating haptens to eliminate the recognition of linker antibodies. Indirect competitive ELISA (ic-ELISA) was developed with a 50% inhibition concentration (IC50) of 0.21 mg/L and a limit of detection (LOD) of 0.06 mg/L in buffer solution. The average recoveries of HA from spiked food samples for this ic-ELISA ranged from 84.1% and 108.5%, and the analysis results agreed well with those of referenced LC-MS/MS. This investigation not only realized derivatization-free immunoassay for HA, but also provided a valuable guidance for hapten design and development of immunoassay for small molecules