Role of dimensional crossover on spin-orbit torque efficiency in magnetic insulator thin films

Magnetic insulators (MIs) attract tremendous interest for spintronic applications due to low Gilbert damping and absence of Ohmic loss. Magnetic order of MIs can be manipulated and even switched by spin-orbit torques (SOTs) generated through spin Hall effect and Rashba-Edelstein effect in heavy metal/MI bilayers. SOTs on MIs are more intriguing than magnetic metals since SOTs cannot be transferred to MIs through direct injection of electron spins. Understanding of SOTs on MIs remains elusive, especially how SOTs scale with the film thickness. Here, we observe the critical role of dimensionality on the SOT efficiency by systematically studying the MI layer thickness dependent SOT efficiency in tungsten/thulium iron garnet (W/TmIG) bilayers. We first show that the TmIG thin film evolves from two-dimensional to three-dimensional magnetic phase transitions as the thickness increases, due to the suppression of long-wavelength thermal fluctuation. Then, we report the significant enhancement of the measured SOT efficiency as the thickness increases. We attribute this effect to the increase of the magnetic moment density in concert with the suppression of thermal fluctuations. At last, we demonstrate the current-induced SOT switching in the W/TmIG bilayers with a TmIG thickness up to 15 nm. The switching current density is comparable with those of heavy metal/ferromagnetic metal cases. Our findings shed light on the understanding of SOTs in MIs, which is important for the future development of ultrathin MI-based low-power spintronics

The transcriptional coactivator TAZ regulates reciprocal differentiation of T(h)17 cells and T(reg) cells

自身免疫性疾病是一类机体对自身抗原发生免疫反应而导致自身多器官、组织受累的慢性炎症性疾病。目前大量研究表明机体内促炎症的TH17细胞和抑制炎症Treg细胞在类群数量和活化状态的失衡是造成自身免疫疾病的主要致病因素。陈兰芬教授和周大旺教授团队的前期研究发现小鼠中Hippo信号通路中激酶Mst1/2缺失导致免疫缺陷，机体易受病原体感染并伴随着严重自身免疫疾病。该研究揭示了Hippo 信号通路转录共激活因子TAZ在决定CD4+初始T细胞分化为促进炎症的TH17效应细胞和抑制免疫反应的Treg调节性细胞过程中发挥着关键作用，拓展了当前对于Hippo信号通路的相关研究内容。 陈兰芬，博士，厦门大学生命科学学院教授。【Abstraact】An imbalance in the lineages of immunosuppressive regulatory T cells (Treg cells) and the inflammatory TH17 subset of helper T cells leads to the development of autoimmune and/or inflammatory disease. Here we found that TAZ, a coactivator of TEAD transcription factors of Hippo signaling, was expressed under T H17 cell–inducing conditions and was required for TH17 differentiation and TH17 cell–mediated inflammatory diseases. TAZ was a critical co-activator of the TH17-defining transcription factor RORγt. In addition, TAZ attenuated Treg cell development by decreasing acetylation of the Treg cell master regulator Foxp3 mediated by the histone acetyltransferase Tip60, which targeted Foxp3 for proteasomal degradation. In contrast, under T regcell–skewing conditions, TEAD1 expression and sequestration of TAZ from the transcription factors RORγt and Foxp3 promoted Treg cell differentiation. Furthermore, deficiency in TAZ or overexpression of TEAD1 induced Treg cell differentiation, whereas expression of a transgene encoding TAZ or activation of TAZ directed TH17 cell differentiation. Our results demonstrate a pivotal role for TAZ in regulating the differentiation of Treg cells and TH17 cells.J. Avruch for comments on the manuscript.Supported by the National Basic Research Program (973) of China (2015CB910502 to L.C.), the National Natural Science Foundation of China (81422018 to L.C.; 31625010 and U1505224 to D.Z.; U1405225 and 81372617 to L.C.; J1310027 to D.Z.; 81472229 to L.H.; and 31600698 to J. Geng), the 111 Projects (B12001 and B06016), China's 1000 Young Talents Program (D.Z., and L.C.), the Fundamental Research Funds for the Central Universities of China-Xiamen University (20720160071 to D.Z. and 20720160054 to L.H.) and Major disease research projects of Xiamen (3502Z20149029 to L.C.)

Cognition investigation and analysis of hand hygiene of nursing staff in pension institutions

Objective: We investigate and analyze the cognition of hand hygiene of nursing staff in nursing institutions. This method provides reference for improving the hand hygiene condition of nursing staff in nursing homes, and we put forward the feasible solution to this situation. Methods: 100 nurses from five nursing institutions in Changchun were investigated using a self-designed questionnaire, and the results were analyzed. Results: due to the most old-age care institutions personnel are less educated, rapid flow of talents, and the health care training from endowment organization are low frequency or not organized, so most of nursing staff think hand hygiene has nothing to do with the health of the elderly. They grasp the knowledge of some common hand washing, and hand washing before and after the elderly care is not ideal. The effects of hand washing have a number of factors, the main factor is that the pension institutions hand washing facilities incomplete, and in fact the nursing staff work very busy. Discussion: from the government to pension institutions should strengthen and pay more attention to the training of pension agency front-line care staff hand hygiene knowledge, increase the training of professional nursing practitioners, focus on bringing in Colleges and universities social science or medical science related, similar professional personnel and institutional strengthening management of washing hands, according to the actual conditions to improve the hand washing facilities, adhere to wash their hands properly, so as to avoid occurrence of handling of disease spread

Effect of Songyu Anshen Fang on expression of hypothalamic GABA and GABA(B) receptor proteins in insomniac rats induced by para-chlorophenylalanine

Purpose: To investigate the effects of the Chinese compound, Songyu Anshen Fang (SYF) on levels of GABA and GABA(B) receptor proteins in insomniac rats induced by para-chlorophenylalanine (PCPA).Methods: All rats were randomly separated into either a control group, insomnia group, or a SYF group (at a dose of 8.5 g/kg or 17 g/kg body weight per day). The rat model of insomnia was induced by intraperitoneal injection of PCPA, and SYF was administered intragastrically in suspension. All experimental groups were treated with a corresponding agent for one week. The levels of glutamic acid (Glu) and γ-aminobutyric acid (GABA) were determined by high performance liquid chromatography (HPLC); mRNA and protein expressions, and GABA(B) receptor levels were detected by real-time polymerase chain reaction (RT-PCR) and western blot.Results: SYF treatment with 8.5 or 17 g/kg/day decreased the levels of Glu and Glu/GABA ratios in the hypothalamus following abnormal increase by PCPA. Moreover, GABA(B) receptor, mRNA and protein expression decreased by PCPA in hypothalamus were significantly normalized by SYF.Conclusion: The study indicates that the effects of PCPA-induced insomnia can be alleviated by SYF modulation of neurotransmitter levels and the expression of GABA(B) receptor in the hypothalamus. This suggests that clinical application of SYF to treat insomnia may be feasible.Keywords: Songyu Anshen Fang, Para-chlorophenylalanine (PCPA), γ-Aminobutyric acid (GABA), GABA(B) receptor, Insomni

Coastal Aquaculture Extraction Using GF-3 Fully Polarimetric SAR Imagery: A Framework Integrating UNet++ with Marker-Controlled Watershed Segmentation

Coastal aquaculture monitoring is vital for sustainable offshore aquaculture management. However, the dense distribution and various sizes of aquacultures make it challenging to accurately extract the boundaries of aquaculture ponds. In this study, we develop a novel combined framework that integrates UNet++ with a marker-controlled watershed segmentation strategy to facilitate aquaculture boundary extraction from fully polarimetric GaoFen-3 SAR imagery. First, four polarimetric decomposition algorithms were applied to extract 13 polarimetric scattering features. Together with the nine other polarisation and texture features, a total of 22 polarimetric features were then extracted, among which four were optimised according to the separability index. Subsequently, to reduce the “adhesion” phenomenon and separate adjacent and even adhering ponds into individual aquaculture units, two UNet++ subnetworks were utilised to construct the marker and foreground functions, the results of which were then used in the marker-controlled watershed algorithm to obtain refined aquaculture results. A multiclass segmentation strategy that divides the intermediate markers into three categories (aquaculture, background and dikes) was applied to the marker function. In addition, a boundary patch refinement postprocessing strategy was applied to the two subnetworks to extract and repair the complex/error-prone boundaries of the aquaculture ponds, followed by a morphological operation that was conducted for label augmentation. An experimental investigation performed to extract individual aquacultures in the Yancheng Coastal Wetlands indicated that the crucial features for aquacultures are Shannon entropy (SE), the intensity component of SE (SE_I) and the corresponding mean texture features (Mean_SE and Mean_SE_I). When the optimal features were introduced, our proposed method performed better than standard UNet++ in aquaculture extraction, achieving improvements of 1.8%, 3.2%, 21.7% and 12.1% in F1, IoU, MR and insF1, respectively. The experimental results indicate that the proposed method can handle the adhesion of both adjacent objects and unclear boundaries effectively and capture clear and refined aquaculture boundaries

The progress of common prosperity in China

This paper examines the extant research progress of the common prosperity in China. Centrals on the topic of common prosperity, the author reviews the progress of Chinese common prosperity from a couple of perspectives: namely the relations between common prosperity and the essence of 20th National Congress of the Communist Party of China; the path and measures to achieve the common prosperity; the nexus among digital economy transition, financial inclusion, household consumption, regional coordinative development and common prosperity; and finally the measurement of the current level of common prosperity. In general, the theme of common prosperity has aroused wide focus in the academic community at home and abroad. From the perspective of literature review in particular, this paper summarizes the current research progress associated with common prosperity in China