Analysis on Lamb's Problem

Ph.DDOCTOR OF PHILOSOPH

TcGAN: Semantic-Aware and Structure-Preserved GANs with Individual Vision Transformer for Fast Arbitrary One-Shot Image Generation

One-shot image generation (OSG) with generative adversarial networks that learn from the internal patches of a given image has attracted world wide attention. In recent studies, scholars have primarily focused on extracting features of images from probabilistically distributed inputs with pure convolutional neural networks (CNNs). However, it is quite difficult for CNNs with limited receptive domain to extract and maintain the global structural information. Therefore, in this paper, we propose a novel structure-preserved method TcGAN with individual vision transformer to overcome the shortcomings of the existing one-shot image generation methods. Specifically, TcGAN preserves global structure of an image during training to be compatible with local details while maintaining the integrity of semantic-aware information by exploiting the powerful long-range dependencies modeling capability of the transformer. We also propose a new scaling formula having scale-invariance during the calculation period, which effectively improves the generated image quality of the OSG model on image super-resolution tasks. We present the design of the TcGAN converter framework, comprehensive experimental as well as ablation studies demonstrating the ability of TcGAN to achieve arbitrary image generation with the fastest running time. Lastly, TcGAN achieves the most excellent performance in terms of applying it to other image processing tasks, e.g., super-resolution as well as image harmonization, the results further prove its superiority

How does authentic leadership promote taking charge: The mediating effect of team social capital and the moderating effect of absorptive capacity

Authentic leaders are consistent with the expectations of Chinese traditional cultural values for leaders. The purpose of this study is to take team internal social capital (TISC) as the mediating variable and individual absorptive capacity as the moderating variable to explore the relationship between authentic leadership and taking charge. We collected 337 questionnaires from China and used linear regression to explore the influencing mechanisms and boundary conditions. The study results showed that the trickle-down of authentic leadership and the trickle-round of TISC can directly promote employees’ taking charge. Further, individual absorptive capacity positively moderated the relationship between TISC and taking charge. Our study provides a new perspective of leadership support for employees to implement taking charge in the context of high-power distance in China. From the perspective of authentic leadership, it is verified that leadership support is a necessary condition to motivate employees to implement proactive behavior. Moreover, compared with the research on the influence of leadership on proactive behavior, team-related and organization-related factors have not received enough attention. According to the social learning theory, we constructed an integrated framework for the first time in which leadership, team, and individual jointly affect taking charge

Computational spatiotemporal analysis identifies WAVE2 and cofilin as joint regulators of costimulation-mediated T cell actin dynamics

Fluorescence microscopy is one of the most important tools in cell biology research and it provides spatial and temporal information to investigate regulatory systems inside cells. This technique can generate data in the form of signal intensities at thousands of positions resolved inside individual live cells; however, given extensive cell-to-cell variation, methods do not currently exist to assemble these data into three- or four-dimensional maps of protein concentration that can be compared across different cells and conditions. Here, we have developed one such method and applied it to investigate actin dynamics in T cell activation. Antigen recognition in T cells by the T cell receptor (TCR) is amplified by engagement of the costimulatory receptor CD28 and we have determined how CD28 modulates actin dynamics. We imaged actin and eight core actin regulators under conditions where CD28 in the context of a strong TCR signal was engaged or blocked to yield over a thousand movies. Our computational analysis identified diminished recruitment of the activator of actin nucleation WAVE2 and the actin severing protein cofilin to F-actin as the dominant difference upon costimulation blockade. Reconstitution of WAVE2 and cofilin activity restored the defect in actin signaling dynamics upon costimulation blockade. Thus we have developed and validated an approach to quantify protein distributions in time and space for analysis of complex regulatory systems

Associations of psychological wellbeing with COVID-19 hospitalization and mortality in adults aged 50 years or older from 25 European countries and Israel

BackgroundLower psychological wellbeing is associated with poor outcomes in a variety of diseases and healthy populations. However, no study has investigated whether psychological wellbeing is associated with the outcomes of COVID-19. This study aimed to determine whether individuals with lower psychological wellbeing are more at risk for poor outcomes of COVID-19.MethodsData were from the Survey of Health, Aging, and Retirement in Europe (SHARE) in 2017 and SHARE's two COVID-19 surveys in June–September 2020 and June–August 2021. Psychological wellbeing was measured using the CASP-12 scale in 2017. The associations of the CASP-12 score with COVID-19 hospitalization and mortality were assessed using logistic models adjusted for age, sex, body mass index, smoking, physical activity, household income, education level, and chronic conditions. Sensitivity analyses were performed by imputing missing data or excluding cases whose diagnosis of COVID-19 was solely based on symptoms. A confirmatory analysis was conducted using data from the English Longitudinal Study of Aging (ELSA). Data analysis took place in October 2022.ResultsIn total, 3,886 individuals of 50 years of age or older with COVID-19 were included from 25 European countries and Israel, with 580 hospitalized (14.9%) and 100 deaths (2.6%). Compared with individuals in tertile 3 (highest) of the CASP-12 score, the adjusted odds ratios (ORs) of COVID-19 hospitalization were 1.81 (95% CI, 1.41–2.31) for those in tertile 1 (lowest) and 1.37 (95% CI, 1.07–1.75) for those in tertile 2. As for COVID-19 mortality, the adjusted ORs were 2.05 (95% CI, 1.12–3.77) for tertile 1 and 1.78 (95% CI, 0.98–3.23) for tertile 2, compared with tertile 3. The results were relatively robust to missing data or the exclusion of cases solely based on symptoms. This inverse association of the CASP-12 score with COVID-19 hospitalization risk was also observed in ELSA.ConclusionThis study shows that lower psychological wellbeing is independently associated with increased risks of COVID-19 hospitalization and mortality in European adults aged 50 years or older. Further study is needed to validate these associations in recent and future waves of the COVID-19 pandemic and other populations

Sufficient and necessary conditions of complete convergence for asymptotically negatively associated random variables

Abstract In this investigation, some sufficient and necessary conditions of the complete convergence for weighted sums of asymptotically negatively associated (ANA, in short) random variables are presented without the assumption of identical distribution. As an application of the main results, the Marcinkiewicz–Zygmund type strong law of large numbers based on weighted sums of ANA cases is obtained. The results of this paper extend and generalize some well-known corresponding ones