306 research outputs found
Predictive Ability of QCD Sum Rules for Excited Baryons
The masses of octet baryons are calculated by the method of QCD sum rules.
Using generalized interpolating fields, three independent sets of QCD sum rules
are derived which allow the extraction of low-lying N* states with spin-parity
1/2+, 1/2- and 3/2- in both the non-strange and strange channels. The
predictive ability of the sum rules is examined by a Monte-Carlo based analysis
procedure in which the three phenomenological parameters (mass, coupling,
threshold) are treated as free parameters simultaneously. Realistic
uncertainties in these parameters are obtained by simultaneously exploring all
uncertainties in the QCD input parameters. Those sum rules with good predictive
power are identified and their predictions are compared with experiment where
available.Comment: 33 pages, 2 figure
Large scale fabrication of nitrogen vacancy-embedded diamond nanostructures for single-photon source applications
Some color centers in diamond can serve as quantum bits which can be manipulated with microwave pulses and read out with laser, even at room temperature. However, the photon collection efficiency of bulk diamond is greatly reduced by refraction at the diamond/air interface. To address this issue, we fabricated arrays of diamond nanostructures, differing in both diameter and top end shape, with HSQ and Cr as the etching mask materials, aiming toward large scale fabrication of single-photon sources with enhanced collection efficiency made of nitrogen vacancy (NV) embedded diamond. With a mixture of O2 and CHF3 gas plasma, diamond pillars with diameters down to 45 nm were obtained. The top end shape evolution has been represented with a simple model. The tests of size dependent single-photon properties confirmed an improved single-photon collection efficiency enhancement, larger than tenfold, and a mild decrease of decoherence time with decreasing pillar diameter was observed as expected. These results provide useful information for future applications of nanostructured diamond as a single-photon source
Evidence for reversible control of magnetization in a ferromagnetic material via spin-orbit magnetic field
Conventional computer electronics creates a dichotomy between how information
is processed and how it is stored. Silicon chips process information by
controlling the flow of charge through a network of logic gates. This
information is then stored, most commonly, by encoding it in the orientation of
magnetic domains of a computer hard disk. The key obstacle to a more intimate
integration of magnetic materials into devices and circuit processing
information is a lack of efficient means to control their magnetization. This
is usually achieved with an external magnetic field or by the injection of
spin-polarized currents. The latter can be significantly enhanced in materials
whose ferromagnetic properties are mediated by charge carriers. Among these
materials, conductors lacking spatial inversion symmetry couple charge currents
to spin by intrinsic spin-orbit (SO) interactions, inducing nonequilibrium spin
polarization tunable by local electric fields. Here we show that magnetization
of a ferromagnet can be reversibly manipulated by the SO-induced polarization
of carrier spins generated by unpolarized currents. Specifically, we
demonstrate domain rotation and hysteretic switching of magnetization between
two orthogonal easy axes in a model ferromagnetic semiconductor.Comment: 10 pages including supplemental materia
Direct measurement of photoinduced transient conducting state in multilayer 2H-MoTe2
Ultrafast light-matter interaction has emerged as a powerful tool to control
and probe the macroscopic properties of functional materials, especially
two-dimensional transition metal dichalcogenides which can form different
structural phases with distinct physical properties. However, it is often
difficult to accurately determine the transient optical constants. In this
work, we developed a near-infrared pump - terahertz to midinfrared (12-22 THz)
probe system in transmission geometry to measure the transient optical
conductivity in 2H-MoTe2 layered material. By performing separate measurements
on bulk and thin-film samples, we are able to overcome issues related to
nonuniform substrate thickness and penetration depth mismatch and to extract
the transient optical constants reliably. Our results show that photoexcitation
at 690 nm induces a transient insulator-metal transition, while photoexcitation
at 2 um has a much smaller effect due to the photon energy being smaller than
the band gap of the material. Combining this with a single-color pump-probe
measurement, we show that the transient response evolves towards 1T' phase at
higher flunece. Our work provides a comprehensive understanding of the
photoinduced phase transition in the 2H-MoTe2 system.Comment: Phys.Rev.Applied accepted, 9 pages, 11 figure
Serratamolide is a hemolytic factor produced by Serratia marcescens
Serratia marcescens is a common contaminant of contact lens cases and lenses. Hemolytic factors of S. marcescens contribute to the virulence of this opportunistic bacterial pathogen. We took advantage of an observed hyper-hemolytic phenotype of crp mutants to investigate mechanisms of hemolysis. A genetic screen revealed that swrW is necessary for the hyper-hemolysis phenotype of crp mutants. The swrW gene is required for biosynthesis of the biosurfactant serratamolide, previously shown to be a broad-spectrum antibiotic and to contribute to swarming motility. Multicopy expression of swrW or mutation of the hexS transcription factor gene, a known inhibitor of swrW expression, led to an increase in hemolysis. Surfactant zones and expression from an swrW-transcriptional reporter were elevated in a crp mutant compared to the wild type. Purified serratamolide was hemolytic to sheep and murine red blood cells and cytotoxic to human airway and corneal limbal epithelial cells in vitro. The swrW gene was found in the majority of contact lens isolates tested. Genetic and biochemical analysis implicate the biosurfactant serratamolide as a hemolysin. This novel hemolysin may contribute to irritation and infections associated with contact lens use. © 2012 Shanks et al
Developing discriminate model and comparative analysis of differentially expressed genes and pathways for bloodstream samples of diabetes mellitus type 2
Background: Diabetes mellitus of type 2 (T2D), also known as noninsulin-dependent diabetes mellitus (NIDDM) or adult-onset diabetes, is a common disease. It is estimated that more than 300 million people worldwide suffer from T2D. In this study, we investigated the T2D, pre-diabetic and healthy human (no diabetes) bloodstream samples using genomic, genealogical, and phonemic information. We identified differentially expressed genes and pathways. The study has provided deeper insights into the development of T2D, and provided useful information for further effective prevention and treatment of the disease. Results: A total of 142 bloodstream samples were collected, including 47 healthy humans, 22 pre-diabetic and 73 T2D patients. Whole genome scale gene expression profiles were obtained using the Agilent Oligo chips that contain over 20,000 human genes. We identified 79 significantly differentially expressed genes that have fold change ≥ 2. We mapped those genes and pinpointed locations of those genes on human chromosomes. Amongst them, 3 genes were not mapped well on the human genome, but the rest of 76 differentially expressed genes were well mapped on the human genome. We found that most abundant differentially expressed genes are on chromosome one, which contains 9 of those genes, followed by chromosome two that contains 7 of the 76 differentially expressed genes. We performed gene ontology (GO) functional analysis of those 79 differentially expressed genes and found that genes involve in the regulation of cell proliferation were among most common pathways related to T2D. The expression of the 79 genes was combined with clinical information that includes age, sex, and race to construct an optimal discriminant model. The overall performance of the model reached 95.1% accuracy, with 91.5% accuracy on identifying healthy humans, 100% accuracy on pre-diabetic patients and 95.9% accuract on T2D patients. The higher performance on identifying pre-diabetic patients was resulted from more significant changes of gene expressions among this particular group of humans, which implicated that patients were having profound genetic changes towards disease development. Conclusion: Differentially expressed genes were distributed across chromosomes, and are more abundant on chromosomes 1 and 2 than the rest of the human genome. We found that regulation of cell proliferation actually plays an important role in the T2D disease development. The predictive model developed in this study has utilized the 79 significant genes in combination with age, sex, and racial information to distinguish pre-diabetic, T2D, and healthy humans. The study not only has provided deeper understanding of the disease molecular mechanisms but also useful information for pathway analysis and effective drug target identification
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