The effect of continuous venovenous hemofiltration on neutrophil gelatinase-associated lipocalin plasma levels in patients with septic acute kidney injury

International audienceCe texte d’introduction au dossier de Flux 2017/2 (N° 108) questionne l’émergence de la thématique de la circularité des matières dans les politiques publiques urbaines contemporaines. Les articles ont en commun de porter une attention minutieuse à la matérialité des flux qui traversent et constituent la ville et aux objets sociaux qui la composent. Ils analysent les modalités et les conséquences de leur mise en circulation, ainsi que les régulations et les conflits qui l’accompagnent. Que l’ensemble des articles traite de pratiques et de politiques ancrées dans l’espace de la région de Lyon résulte moins d’une volonté monographique que d’une rencontre en partie fortuite. Mais cela souligne en tout cas l’importance d’une approche toujours attentive aux faits géographiques et aux effets de lieu dans la diversité de leurs échelles. Trois thématiques transversales sont présentes : d’abord, en identifiant de nouvelles ressources, les articles permettent de réfléchir à l’invention et à la construction de nouveaux circuits pour les matières. Ensuite, la régulation de ces circuits implique l’identification de nouveaux acteurs et la mise en place de nouvelles formes de relations avec les producteurs et gestionnaires des matières, formant donc l’espace d’une gouvernance renouvelée. Enfin, si ces circuits se structurent dans un espace qui est celui de la proximité géographique, ils s’inscrivent néanmoins dans une logique relationnelle qui ne cesse de questionner les normes et les échelles. Ce numéro permet ainsi de nuancer et de re-matérialiser les injonctions à faire advenir l’économie circulaire dans les villes

The impact of tracheotomy on levels of procalcitonin in patients without sepsis: a prospective study

OBJECTIVE:Procalcitonin is a reliable biomarker of infection and sepsis. We aimed to determine whether tracheotomy influences the procalcitonin concentrations in patients without sepsis and assess whether operative duration and procedure affect the peak procalcitonin level.METHODS:A total of 38 non-septic patients who required a tracheotomy underwent either a percutaneous dilatational tracheotomy (n=19) or a surgical tracheotomy (n=19). Procalcitonin levels were measured at the beginning of the tracheotomy and at 2 h, 4 h, 8 h, 24 h, 48 h and 72 h after the procedure.RESULTS:The baseline procalcitonin concentration before the tracheotomy was 0.24±0.13 ng/mL. The postoperative levels increased rapidly, with a 4-fold elevation after 2 h, reaching a peak 4 h later with a 5-fold increase over baseline. Thereafter, the levels gradually returned to 2-fold greater than the baseline level within 72 h. The peak levels of procalcitonin showed a significant positive correlation with operative durations (r=0.710,

SIRT1/3 Activation by Resveratrol Attenuates Acute Kidney Injury in a Septic Rat Model

Sepsis often results in damage to multiple organ systems, possibly due to severe mitochondrial dysfunction. Two members of the sirtuin family, SIRT1 and SIRT3, have been implicated in the reversal of mitochondrial damage. The aim of this study was to determine the role of SIRT1/3 in acute kidney injury (AKI) following sepsis in a septic rat model. After drug pretreatment and cecal ligation and puncture (CLP) model reproduction in the rats, we performed survival time evaluation and kidney tissue extraction and renal tubular epithelial cell (RTEC) isolation. We observed reduced SIRT1/3 activity, elevated acetylated SOD2 (ac-SOD2) levels and oxidative stress, and damaged mitochondria in RTECs following sepsis. Treatment with resveratrol (RSV), a chemical SIRT1 activator, effectively restored SIRT1/3 activity, reduced acetylated SOD2 levels, ameliorated oxidative stress and mitochondrial function of RTECs, and prolonged survival time. However, the beneficial effects of RSV were greatly abrogated by Ex527, a selective inhibitor of SIRT1. These results suggest a therapeutic role for SIRT1 in the reversal of AKI in septic rat, which may rely on SIRT3-mediated deacetylation of SOD2. SIRT1/3 activation could therefore be a promising therapeutic strategy to treat sepsis-associated AKI

Bioinformatics and system biology approach to identify the influences among COVID-19, ARDS and sepsis

Background Severe coronavirus disease 2019 (COVID -19) has led to severe pneumonia or acute respiratory distress syndrome (ARDS) worldwide. we have noted that many critically ill patients with COVID-19 present with typical sepsis-related clinical manifestations, including multiple organ dysfunction syndrome, coagulopathy, and septic shock. The molecular mechanisms that underlie COVID-19, ARDS and sepsis are not well understood. The objectives of this study were to analyze potential molecular mechanisms and identify potential drugs for the treatment of COVID-19, ARDS and sepsis using bioinformatics and a systems biology approach. Methods Three RNA-seq datasets (GSE171110, GSE76293 and GSE137342) from Gene Expression Omnibus (GEO) were employed to detect mutual differentially expressed genes (DEGs) for the patients with the COVID-19, ARDS and sepsis for functional enrichment, pathway analysis, and candidate drugs analysis. Results We obtained 110 common DEGs among COVID-19, ARDS and sepsis. ARG1, FCGR1A, MPO, and TLR5 are the most influential hub genes. The infection and immune-related pathways and functions are the main pathways and molecular functions of these three diseases. FOXC1, YY1, GATA2, FOXL, STAT1 and STAT3 are important TFs for COVID-19. mir-335-5p, miR-335-5p and hsa-mir-26a-5p were associated with COVID-19. Finally, the hub genes retrieved from the DSigDB database indicate multiple drug molecules and drug-targets interaction. Conclusion We performed a functional analysis under ontology terms and pathway analysis and found some common associations among COVID-19, ARDS and sepsis. Transcription factors–genes interaction, protein–drug interactions, and DEGs-miRNAs coregulatory network with common DEGs were also identified on the datasets. We believe that the candidate drugs obtained in this study may contribute to the effective treatment of COVID-19

Decision-Making in Patients with Hyperthyroidism: A Neuropsychological Study

<div><p>Introduction</p><p>Cognitive and behavioral impairments are common in patients with abnormal thyroid function; these impairments cause a reduction in their quality of life. The current study investigates the decision making performance in patients with hyperthyroidism to explore the possible mechanism of their cognitive and behavioral impairments.</p><p>Methods</p><p>Thirty-eight patients with hyperthyroidism and forty healthy control subjects were recruited to perform the Iowa Gambling Task (IGT), which assessed decision making under ambiguous conditions.</p><p>Results</p><p>Patients with hyperthyroidism had a higher score on the Zung Self-Rating Anxiety Scale (Z-SAS), and exhibited poorer executive function and IGT performance than did healthy control subjects. The patients preferred to choose decks with a high immediate reward, despite a higher future punishment, and were not capable of effectively using feedback information from previous choices. No clinical characteristics were associated with the total net score of the IGT in the current study.</p><p>Conclusions</p><p>Patients with hyperthyroidism had decision-making impairment under ambiguous conditions. The deficits may result from frontal cortex and limbic system metabolic disorders and dopamine dysfunction.</p></div

The mean frequency of advantageous choices (A+B) and mean frequency of disadvantageous choices (C+D) for the hyperthyroidism group and the healthy control group.

<p>Error bars indicate standard errors of the mean. Items marked with *: <i>p</i> < 0.01.</p

The mean net scores of the 5 blocks, consisting of 20 trials each, for the hyperthyroidism group and the healthy control group.

<p>Error bars indicate standard errors of the mean. Items marked with *: <i>p</i> < 0.05. Items marked with **: <i>p</i> < 0.05.</p

Demographic and background data of the hyperthyroidism group and healthy control group.

<p>Demographic and background data of the hyperthyroidism group and healthy control group.</p