Microbiota and bile acid profiles in retinoic acid-primed mice that exhibit accelerated liver regeneration.

Background & aimsAll-trans Retinoic acid (RA) regulates hepatic lipid and bile acid homeostasis. Similar to bile acid (BA), RA accelerates partial hepatectomy (PHx)-induced liver regeneration. Because there is a bidirectional regulatory relationship between gut microbiota and BA synthesis, we examined the effect of RA in altering the gut microbial population and BA composition and established their relationship with hepatic biological processes during the active phases of liver regeneration.MethodsC57BL/6 mice were treated with RA orally followed by 2/3 PHx. The roles of RA in shifting gut microbiota and BA profiles as well as hepatocyte metabolism and proliferation were studied.ResultsRA-primed mice exhibited accelerated hepatocyte proliferation revealed by higher numbers of Ki67-positive cells compared to untreated mice. Firmicutes and Bacteroidetes phyla dominated the gut microbial community (>85%) in both control and RA-primed mice after PHx. RA reduced the ratio of Firmicutes to Bacteroidetes, which was associated with a lean phenotype. Consistently, RA-primed mice lacked transient lipid accumulation normally found in regenerating livers. In addition, RA altered BA homeostasis and shifted BA profiles by increasing the ratio of hydrophilic to hydrophobic BAs in regenerating livers. Accordingly, metabolic regulators fibroblast growth factor 21, Sirtuin1, and their downstream targets AMPK and ERK1/2 were more robustly activated in RA-primed than unprimed regenerating livers.ConclusionsPriming mice with RA resulted in a lean microbiota composition and hydrophilic BA profiles, which were associated with facilitated metabolism and enhanced cell proliferation

The effect of Tai Chi intervention on balance in older males

AbstractPurposeThe purpose of the present study was to examine the effects of a 24-week Tai Chi exercise intervention on balance and other physical changes such as flexibility and reaction time (RT) among healthy older males.MethodsThirty-eight male subjects aged 55–65 years without prior Tai Chi experience were recruited from a local community in Shanghai, China. A 60-min Tai Chi exercise session was performed three times a week for 24 weeks. Changes in RT, sit-and-reach flexibility and balance (static balance with eyes open and closed respectively) were measured before and after the Tai Chi intervention.ResultsAfter the 24-week Tai Chi intervention, the choice RT (p < 0.05) decreased, and sit-and-reach flexibility improved (p < 0.01) over the pre-test (7.8±6.2 vs. 7.1±3.0cm). Sway length, area, X-axis deviation amplitude and Y-axis deviation amplitude performance decreased significantly after the intervention with a double-foot stance with eyes open (p < 0.05). Sway length, area and average sway speed showed a statistically significant decrease after the intervention with the double-foot stance with eyes closed. In the single-foot stance with eyes open condition, sway length and average sway speed showed a statistically significant decrease (p < 0.05).ConclusionThe 24-week Tai Chi exercise intervention had a positive influence on balance control in older males

Phase transitions in a holographic s+p model with backreaction

In a previous paper (arXiv:1309.2204, JHEP 1311 (2013) 087), we present a holographic s+p superconductor model with a scalar triplet charged under an SU(2) gauge field in the bulk. We also study the competition and coexistence of the s-wave and p-wave orders in the probe limit. In this work we continue to study the model by considering the full back-reaction The model shows a rich phase structure and various condensate behaviors such as the "n-type" and "u-type" ones, which are also known as reentrant phase transitions in condensed matter physics. The phase transitions to the p-wave phase or s+p coexisting phase become first order in strong back-reaction cases. In these first order phase transitions, the free energy curve always forms a swallow tail shape, in which the unstable s+p solution can also play an important role. The phase diagrams of this model are given in terms of the dimension of the scalar order and the temperature in the cases of eight different values of the back reaction parameter, which show that the region for the s+p coexisting phase is enlarged with a small or medium back reaction parameter, but is reduced in the strong back-reaction cases.Comment: 15 pages(two-column), 9 figure

Theoretical Study on Rotational Bands and Shape Coexistence of 183,185,187^{183,185,187}{Tl} in the Particle Triaxial-Rotor Model

By taking the particle triaxial-rotor model with variable moment of inertia, we investigate the energy spectra, the deformations and the single particle configurations of the nuclei $^{183,185,187}$Tl systemically. The calculated energy spectra agree with experimental data quite well. The obtained results indicate that the aligned bands observed in $^{183,185,187}$Tl originate from the $[530]{{1/2}}^{-}$, $[532]{{3/2}}^{-}$, $[660]{{1/2}}^{+}$ proton configuration coupled to a prolate deformed core, respectively. Whereas, the negative parity bands built upon the ${{9/2}}^{-}$ isomeric states in $^{183,185,187}$Tl are formed by a proton with the $[505]{{9/2}}^{-}$ configuration coupled to a core with triaxial oblate deformation, and the positive parity band on the ${{13/2}}^{+}$ isomeric state in $^{187}$Tl is generated by a proton with configuration $[606]{{13/2}}^{+}$ coupled to a triaxial oblate core.Comment: 16 pages, 5 figures. To appear in Physical Review