Current Perspectives on Role of MSC in Renal Pathophysiology

In the course of the development and worsening of kidney disease, the treatments available are expensive and may cause adverse effects such as immune rejection, inadequate renal resources, or post-operative complications. Therefore, there is an urgent to develop more effective treatments. The advent of mesenchymal stem cells (MSCs) represents a new direction in this context. The current use of MSCs for the treatment of kidney disease has mostly involved experimental studies on animals and only a few clinical trials have been conducted. This review focused on the mechanisms of MSC involvement from different sources in the improvement of renal pathophysiology in recent years. These mechanisms include homing to damaged kidney tissue, and differentiating into or fusing with the innate cells of the kidney. The paracrine or endocrine action through secreting protective cytokines and/or releasing microvesicle from MSCs also plays a critical role in amelioration of kidney disease. With modern engineering technology like microRNA delivery and a combinational therapy approach such as reduction of renal fibrosis in obstructive nephropathy with MSCs and serelaxin, MSC may make great contribution to the improvement of renal pathophysiology. However, the therapeutic effects of MSC are still controversial and several problems remain unsolved. While it is too early to state that MSCs are useful for the treatment of renal diseases in clinic, it is thought that solutions to the existing problems will enable effective modulation of the biological characteristics of MSCs, thereby providing new and effective approaches for the treatment of renal diseases

The Effects of Electrical Acupuncture and Essential Amino Acid Supplementation on Sarcopenic Obesity in Male Older Adults: A Randomized Control Study

Objective: Aging which is accompanied by loss of skeletal muscle and increase of body fat in some adults older than 60 years does not only result in remarkable influences on daily life function but also increases the risk of cardiovascular events. This study used electrical acupuncture together with essential amino acid supplementation to treat sarcopenic obesity (SO) in male older adults. Methods: A total of 48 male participants with SO (>60 years old) were randomized to electrical acupuncture with oral essential amino acids (EA + AA) or oral essential amino acids alone (AA). Acupuncture points on the limbs were punctured and stimulated electrically once every 3 days for 12 weeks. All participants received essential amino acids orally, twice per day for 28 weeks. Body fat percentage (BFP) and appendicular skeletal muscle index (ASM/H2) was determined by bioelectrical impedance analysis. Results: Both groups exhibited significant changes in BFP after 12, 20, and 28 weeks compared with baseline values; for ASM/H2, there were significant differences to baseline values after 12, 20, and 28 weeks in the EA + AA group, but only after 28 weeks in the AA group. Between the two groups, there were significant differences in BFP after 12, 20, and 28 weeks, and in ASM/H2 after 20 and 28 weeks. Conclusion: Both methods decrease BFP and increase ASM/H2. In male older adults, electrical acupuncture with oral essential amino acids is more effective and can increase muscle mass in a shorter time than oral essential amino acids alone

High‐Efficiency, Vacuum‐Deposited, Small‐Molecule Organic Tandem and Triple‐Junction Photovoltaic Cells

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109903/1/aenm201400568.pd

Numerical Simulation of Frost Heave Deformation of Concrete-Lined Canal Considering Thermal-Hydro-Mechanical Coupling Effect

This work presents a comprehensive coupled thermal-hydro-mechanical model to explore the frost heave mechanism of the concrete-lined canal under a freeze–thaw environment. Unlike previous models that regard concrete as a homogeneous material, this model considers concrete a porous medium and considers the effect of the concrete pore structure, as well as the water content, ice content, and ice-water phase transition, on the mechanical deformation of the canal. Firstly, based on the theories of unsaturated soil mechanics, thermodynamics, and poroelasticity, the thermal-hydro-mechanical coupling equations of the soil under the freeze–thaw condition are established. Then, based on the theories of thermodynamics, poroelasticity, and permeability mechanics of porous media, the thermal-hydro-mechanical coupling equations of the concrete under the freeze–thaw condition are established. Finally, the freeze–thaw simulation of a canal is carried out and compared with the referred indoor model test, in which the evolution behavior of temperature, frost depth, and frost heave deformation of the canal are studied. The results show that the freezing process of the soil foundation is a unidirectional process that develops from the surface to the bottom, and the thawing process of the soil foundation is a bidirectional process that thaws from the surface and bottom to the center. The frost heave deformation of the soil foundation at the 1/2~1/3 slope height area is the largest, which may easily lead to frost heave damage to the concrete lining in this area. The frost heave deformation of the canal obtained by the numerical simulation is consistent with the experimental results, which illustrates the validity of the established model for predicting the frost heave deformation of concrete-lined canals