Fusion Reactivities with Drift bi-Maxwellian Ion Velocity Distributions

The calculation of fusion reactivity involves a complex six-dimensional integral that takes into account the fusion cross-section and velocity distributions of two reactants. However, a more simplified one-dimensional integral form can be useful in certain cases, such as for studying fusion yield or diagnosing ion energy spectra. This simpler form has been derived in a few special cases, such as for a combination of two Maxwellian distributions, a beam-Maxwellian combination, and a beam-target combination, and can greatly reduce computational costs. In this study, it is shown that the reactivity for two drift bi-Maxwellian reactants with different drift velocities, temperatures, and anisotropies can also be reduced to a one-dimensional form, unifying existing derivations into a single expression. This result is used to investigate the potential enhancement of fusion reactivity due to the combination of beam and temperature anisotropies. For relevant parameters in fusion energy, the enhancement factor can be larger than 20\%, which is particularly significant for proton-boron (p-B11) fusion, as this factor can have a significant impact on the Lawson fusion gain criteria.Comment: 12 pages, 10 figures, 1 supplementary material for detail derivatio

Particle‐in‐cell simulation of electron cyclotron harmonic waves driven by a loss cone distribution

Electron Cyclotron Harmonic (ECH) waves driven by a loss cone distribution are studied in this work by self‐consistent particle‐in‐cell simulations. These waves have been suggested to play an important role in diffuse auroral precipitation in the outer magnetosphere. However, particle simulation of this instability is difficult because the saturation amplitude of the wave driven by a realistic size loss cone distribution is very small. In this work we use an extraordinarily large number of particles to reduce simulation noise so that the growth and saturation of ECH waves can be investigated. Our simulation results are consistent with linear theory in terms of growth rate, and with observation in terms of wave amplitude. We demonstrate that the heating of cold electrons is negligible and non‐resonant, different from previous conclusions, and suggest that the saturation of the wave is caused by the filling of the loss cone of hot electrons

Expression of the chemokine receptor CXCR4 in human hepatocellular carcinoma and its role in portal vein tumor thrombus

<p>Abstract</p> <p>Background</p> <p>This study was conducted to investigate the expression of CXCR4 in portal vein tumor thrombus (PVTT) tissue and its possible role in the invasiveness of tumor thrombus cells.</p> <p>Methods</p> <p>We detected differential expression of CXCR4 between PVTT and hepatocellular carcinoma (HCC) by an immunohistochemical assay. Lentivirus-mediated RNA interference and a migration assay were performed on human primary cells derived from PVTT to study the impact of CXCR4 on the invasiveness of HCC.</p> <p>Results</p> <p>The expression of CXCR4 in tumor thrombus tissue was higher than that in HCC tissue. The invasion ratio of PVTT cells was significantly decreased (P < 0.05) after being infected with a CXCR4-targeting siRNA lentivirus, indicating that downregulation of CXCR4 by lentivirus-mediated RNA interference significantly impaired the invasive potential of PVTT.</p> <p>Conclusions</p> <p>These results indicate that CXCR4 is an effective curative target for hepatocellular carcinomas with PVTT.</p

MAS: A versatile Landau-fluid eigenvalue code for plasma stability analysis in general geometry

We have developed a new global eigenvalue code, Multiscale Analysis for plasma Stabilities (MAS), for studying plasma problems with wave toroidal mode number n and frequency omega in a broad range of interest in general tokamak geometry, based on a five-field Landau-fluid description of thermal plasmas. Beyond keeping the necessary plasma fluid response, we further retain the important kinetic effects including diamagnetic drift, ion finite Larmor radius, finite parallel electric field, ion and electron Landau resonances in a self-consistent and non-perturbative manner without sacrificing the attractive efficiency in computation. The physical capabilities of the code are evaluated and examined in the aspects of both theory and simulation. In theory, the comprehensive Landau-fluid model implemented in MAS can be reduced to the well-known ideal MHD model, electrostatic ion-fluid model, and drift-kinetic model in various limits, which clearly delineates the physics validity regime. In simulation, MAS has been well benchmarked with theory and other gyrokinetic and kinetic-MHD hybrid codes in a manner of adopting the unified physical and numerical framework, which covers the kinetic Alfven wave, ion sound wave, low-n kink, high-n ion temperature gradient mode and kinetic ballooning mode. Moreover, MAS is successfully applied to model the Alfven eigenmode (AE) activities in DIII-D discharge #159243, which faithfully captures the frequency sweeping of RSAE, the tunneling damping of TAE, as well as the polarization characteristics of KBAE and BAAE being consistent with former gyrokinetic theory and simulation. With respect to the key progress contributed to the community, MAS has the advantage of combining rich physics ingredients, realistic global geometry and high computation efficiency together for plasma stability analysis in linear regime.Comment: 40 pages, 21 figure

Surface morphology of GaN: Flat versus vicinal surfaces

The surface morphology of GaN films grown by molecular beam epitaxy (MBE) is investigated by scanning tunneling microscopy (STM). A comparison is made between flat and vicinal surfaces. The wurtzite structure of GaN leads to special morphological features such as step pairing and triangularly shaped islands. Spiral mounds due to growth at screw threading dislocations are dominant on flat surfaces, whereas for vicinal GaN, the surfaces show no spiral mound but evenly spaced steps. This observation suggests an effective suppression of screw threading dislocations in the vicinal films. This finding is confirmed by transmission electron microscopy (TEM) studies. Continued growth of the vicinal surface leads to step bunching that is attributed to the effect of electromigration.published_or_final_versionThe 1999 Materials Research Society Symposium Fall Meeting - Symposium W 'GaN and Related Alloys', Boston, MA, 28 November - 3 December 1999. In Mrs Internet Journal Of Nitride Semiconductor Research, 2000, v. 5 SUPPL.

Proteomics of a toxic dinoflagellate Alexandrium catenella DH01: Detection and identification of cell surface proteins using fluorescent labeling

Alexandrium catenella DH01 is a toxic dinoflagellate species that is able to not only produce paralytic shellfish toxins, but also cause harmful algal blooms along the coast of China. In this study, we presented a new protocol for specific labeling and detection of the cell surface proteins (CSPs) of A. catenella DH01 cells using CyDye difference gel electrophoresis (DIGE) fluor minimal dyes. CSPs were identified using two-dimensional gel electrophoresis (2-DE) and MALDI TOF-TOF mass spectrometry (MS). The results showed that the fluorescent cyanine dye Cy3 could specifically label the CSPs of A. catenella DH01, with minimal labeling of intracellular proteins. Among three protein extraction methods evaluated, the Trizol method was the most efficient to extract CSPs with respect to protein spot number and resolution. Forty-one CSPs were separated and identified from A. catenella DH01 by 2-DE, in which 14 were identified in the protein database using MALDI TOF-TOF MS analysis. This work represents the first attempt to investigate the CSPs of A. catenella using the CyDye DIGE fluor dyeing method that provides a potentially important tool for future comprehensive characterization of CSPs and elucidation of the physiological functions of CSPs in dinoflagellates.National Natural Science Foundation of China [40876059]; National Key Basic Research Program of China [2010CB428703]; Doctoral Fund of Ministry of Education of China [20070384014]; Excellent Group; Program for New Century Excellent Talents in Universit