Effect of renin-angiotensin system inhibitors on acute kidney injury among patients undergoing cardiac surgery: A review and meta-analysis

10.1053/j.semtcvs.2020.11.024SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY3341014-102

Triaqua­(1,10-phenanthroline-2,9-dicarboxyl­ato)cobalt(II) dihydrate

The title compound, [Co(C14H6N2O4)(H2O)3]·2H2O, has two­fold crystallographic symmetry. The CoII atom is in a distorted penta­gonal-bipyramidal coordination environment with two N atoms and two O atoms from a tetradentate 1,10-phenanthroline-2,9-dicarboxyl­ate ligand and one O atom from a water mol­ecule forming the penta­gonal plane, and two O atoms from two water mol­ecules occupying axial positions. In the crystal, adjacent mol­ecules are linked by O—H⋯O hydrogen bonds, forming a three-dimensional network

Doping effects of Cr on the physical properties of BaFe1.9−x_{1.9-x}Ni0.1_{0.1}Crx_{x}As2_{2}

We present a systematic study on the heavily Cr doped iron pnictides BaFe$_{1.9-x}$Ni$_{0.1}$Cr$_{x}$As$_{2}$ by using elastic neutron scattering, high-resolution synchrotron X-ray diffraction (XRD), resistivity and Hall transport measurements. When the Cr concentration increases from $x=$ 0 to 0.8, neutron diffraction experiments suggest that the collinear antiferromagnetism persists in the whole doping range, where the N\'{e}el temperature $T_N$ coincides with the tetragonal-to-orthorhombic structural transition temperature $T_s$, and both of them keeps around 35 K. The magnetic ordered moment, on the other hand, increases within increasing $x$ until $x=$ 0.5, and then decreases with further increasing $x$. Detailed refinement of the powder XRD patterns reveals that the Cr substitutions actually stretch the FeAs$_4$ tetrahedron along the $c-$axis and lift the arsenic height away Fe-Fe plane. Transport results indicate that the charge carriers become more localized upon Cr doping, then changes from electron-type to hole-type around $x=$ 0.5. Our results suggest that the ordered moment and the ordered temperature of static magnetism in iron pnictides can be decoupled and tuned separately by chemical doping.Comment: 10 pages, 7 figure

Variator: Accelerating Pre-trained Models with Plug-and-Play Compression Modules

Pre-trained language models (PLMs) have achieved remarkable results on NLP tasks but at the expense of huge parameter sizes and the consequent computational costs. In this paper, we propose Variator, a parameter-efficient acceleration method that enhances computational efficiency through plug-and-play compression plugins. Compression plugins are designed to reduce the sequence length via compressing multiple hidden vectors into one and trained with original PLMs frozen. Different from traditional model acceleration methods, which compress PLMs to smaller sizes, Variator offers two distinct advantages: (1) In real-world applications, the plug-and-play nature of our compression plugins enables dynamic selection of different compression plugins with varying acceleration ratios based on the current workload. (2) The compression plugin comprises a few compact neural network layers with minimal parameters, significantly saving storage and memory overhead, particularly in scenarios with a growing number of tasks. We validate the effectiveness of Variator on seven datasets. Experimental results show that Variator can save 53% computational costs using only 0.9% additional parameters with a performance drop of less than 2%. Moreover, when the model scales to billions of parameters, Variator matches the strong performance of uncompressed PLMs.Comment: Accepted by Findings of EMNL

Critical Role of Phosphorus in Hollow Structures Cobalt-Based Phosphides as Bifunctional Catalysts for Water Splitting

Cobalt phosphides electrocatalysts have great potential for water splitting, but the unclear active sides hinder the further development of cobalt phosphides. Wherein, three different cobalt phosphides with the same hollow structure morphology (CoP-HS, CoP-HS, CoP-HS) based on the same sacrificial template of ZIF-67 are prepared. Surprisingly, these cobalt phosphides exhibit similar OER performances but quite different HER performances. The identical OER performance of these CoP-HS in alkaline solution is attributed to the similar surface reconstruction to CoOOH. CoP-HS exhibits the best catalytic activity for HER among these CoP-HS in both acidic and alkaline media, originating from the adjusted electronic density of phosphorus to affect absorption–desorption process on H. Moreover, the calculated ΔG based on P-sites of CoP-HS follows a quite similar trend with the normalized overpotential and Tafel slope, indicating the important role of P-sites for the HER process. Moreover, CoP-HS displays good performance (cell voltage of 1.67 V at a current density of 50 mA cm) and high stability in 1 M KOH. For the first time, this work detailly presents the critical role of phosphorus in cobalt-based phosphides for water splitting, which provides the guidance for future investigations on transition metal phosphides from material design to mechanism understanding.W.Z. and N.H. contributed equally to this work. X.Z. and J.F. are grateful for the Research Foundation-Flanders (FWO) project (12ZV320N). Funding from National Natural Science Foundation of China (project No.: 22005250, 21776120, and 51901161) is appreciated. M.X. is grateful to the National Natural Science Foundation of China (project No.: 22179109). W.Z. is grateful to the China Scholarship Council (NO. 201808310068). W.G. is grateful to the China Scholarship Council (NO. 201806030189). S.X. is grateful to the China Scholarship Council. K.W. is grateful to the Oversea Study Program of Guangzhou Elite Project. Funding from the Research Foundation–Flanders (FWO) (project No.: G0B3218N) and Natural Science Foundation of Fujian Province, China (No.: 2018J01433) is acknowledged. ICN2 acknowledges funding from Generalitat de Catalunya 2017 SGR 327 and the Spanish MINECO project ECOCAT and subproject NANOGEN. ICN2 is supported by the Severo Ochoa program from Spanish MINECO (Grant No. SEV-2017-0706) and is funded by the CERCA Programme/Generalitat de Catalunya. Part of the present work has been performed in the framework of Universitat Autònoma de Barcelona Materials Science Ph.D. program. This work has received funding from the European Union's Horizon 2020 Research and Innovation Programme under grant agreement No. 654360 NFFA-Europe. X.H. thanks China Scholarship Council for scholarship support (201804910551)

Identification and validation of a novel glycolysis-related ceRNA network for sepsis-induced cardiomyopathy

PurposeSepsis-induced cardiomyopathy (SIC) is a major life-threatening condition in critically infected patients. Early diagnosis and intervention are important to improve patient prognosis. Recognizing the pivotal involvement of the glycolytic pathway in SIC, this study aims to establish a glycolysis-related ceRNA network and explore novel diagnostic avenues.Materials and methodsSIC-related datasets were carefully filtered from the GEO database. CytoHubba was used to identify differentially expressed genes (DEGs) associated with glycolysis. A predictive method was then used to construct an lncRNA-miRNA-mRNA network. Dual-luciferase reporter assays validated gene interactions, and the specificity of this ceRNA network was confirmed in peripheral blood mononuclear cells (PBMCs) from SIC patients. Logistic analysis was used to examine the correlation between the ceRNA network and SIC. Diagnostic potential was assessed using receiver operating characteristic (ROC) curves, and correlation analysis investigated any associations between gene expression and clinical indicators.ResultsIER3 was identified as glycolysis-related DEG in SIC, and a ceRNA network (SNHG17/miR-214-3p/IER3) was established by prediction. Dual luciferase reporter gene assay confirmed the presence of mutual binding between IER3, miR-214-3p and SNHG17. RT-qPCR verified the specific expression of this ceRNA network in SIC patients. Multivariate logistic analysis established the correlation between the ceRNA network and SIC. ROC analysis demonstrated its high diagnostic specificity (AUC > 0.8). Correlation analysis revealed a negative association between IER3 expression and oxygenation index in SIC patients (p < 0.05). Furthermore, miR-214-3p expression showed a negative correlation with NT-proBNP (p < 0.05).ConclusionIn this study, we identified and validated a ceRNA network associated with glycolysis in SIC: SNHG17/miR-214-3p/IER3. This ceRNA network may play a critical role in the onset and development of SIC. This finding is important to further our understanding of the pathophysiological mechanisms underlying SIC and to explore potential diagnostic and therapeutic targets for SIC

Case Studies of Environmental Visualization

The performance gap between simulation and reality has been identified as a major challenge to achieving sustainability in the Built Environment. While Post-Occupancy Evaluation (POE) surveys are an integral part of better understanding building performance, and thus addressing this issue, the importance of POE remains relatively unacknowledged within the wider Built Environment community. A possible reason that has been highlighted is that POE survey data is not easily understood and utilizable by non-expert stakeholders, including designers. A potential method by which to address this is the visualization method, which has well established benefits for communication of big datasets. This paper presents two case studies where EnViz (short for “Environmental Visualization”), a prototype software application developed for research purposes, was utilized and its effectiveness tested via a range of analysis tasks. The results are discussed and compared with those of previous work that utilized variations of the methods presented here. The paper concludes by presenting the lessons drawn from the five-year period of EnViz, emphasizing the potential of environmental visualization for decision support in environmental design and engineering for the built environment, and suggests directions for future development

Prism adaptation combined with eye movement training for unilateral spatial neglect after stroke: Study protocol for a single-blind prospective, randomized controlled trial

BackgroundUnilateral spatial neglect (USN) is a complex neurological syndrome that often reduces rehabilitation outcomes, prolongs patients' hospital stays, and decreases their quality of life. However, the current therapies for USN have varying efficacy. We will explore a new treatment option that combines prism adaptation (PA) with eye movement training (EMT) for the treatment of USN after stroke.MethodsWe will conduct a single-blind, prospective, randomized controlled trial to assess the efficacy of the combined intervention (PA & EMT) on USN in an inpatient rehabilitation setting. The study aims to recruit 88 patients with USN after an ischemic or hemorrhagic stroke. Participants will be randomly assigned to the following four groups: (1) PA group (n = 22), (2) EMT group (n = 22), (3) PA and EMT group (n = 22), and (4) control group (n = 22). All groups will receive 10 sessions of interventions over 2 weeks, 5 times per week. Blinded assessors will conduct a baseline assessment, a post-intervention assessment, and a follow-up assessment (2 weeks post-intervention). The primary outcome measure will use the Behavioral Inattention Test-Conventional Subset (BIT-C) and Catherine Bergego Scale (CBS) to assess the levels of USN. Secondary outcome measures will assess the patient's ability to perform activities of daily living using the Modified Barthel Index (MBI). Patients who completed all treatment and assessment sessions will be included in the final analysis.DiscussionThis study will explore the effects of 10 sessions of combined interventions (PA & EMT) on USN and functional capacity. This study has the potential to identify a new, evidence-based treatment option and provide new ideas for the treatment of USN.Ethics and disseminationThe study protocol has been approved by the Nanchong Central Hospital. Written informed consent will be obtained from all the participants. The results of this study will be disseminated to the public through scientific conferences and a peer-reviewed journal.Trial registrationChiCTR, ChiCTR2100049482. Registered on 2 August 2021, http://www.chictr.org.cn/showproj.aspx?proj=130823